Her research has focused on dermatologic side - effects of chemotherapy in dogs and on the common auto - immune diseases,
pemphigus foliaceus and perianal fistulas.
Immune mediated diseases like
pemphigus foliecious (your dog produces antibodies against different components of the skin, resulting in separation of the cells and blistering of the skin)
Autoimmune skin diseases include perianal fistula, sebaceous adenitis, lupus,
pemphigus, nail bed disease, and vitiligo.
These included canine immune mediated thrombocytopenia, lupus, immune mediated polyarthropathy,
pemphigus foliaceus, and immune mediated hemolytic anemia.
Examples of conditions the drug may be used for include lymphocytic leukemia, multiple myeloma, glomerulonephritis, non-erosive arthritis, immune - mediated skin disease, feline
pemphigus foliaceous and severe feline eosinophilic granuloma complex.
Pemphigus can be masked by concurrent skin problems such as flea allergy dermatitis, mange, and atopy (inhalant allergies).
Pets with allergic (flea allergy dermatitis), auto - immune (
pemphigus, rheumatoid arthritis), or inflammatory (arthritis, glomerulonephritis) conditions need more Omega 3 fatty acids.
Canine idiopathic immune - mediated hemolytic anemia, heartworm disease, blood parasites, rickettsial diseases,
Pemphigus foliaceus, systemic lupus erythematosus, etc..
The good thing is that the cortisone type drugs you would use for
the pemphigus won't interfere with the heartworm treatment.
If allergy is eliminated as the cause of a skin problem, other autoimmune conditions such as
pemphigus are considered.»
Typically, we give corticosteroids to control
pemphigus diseases, at pretty high doses.
Their expertise extends from the ears (ear infections, tumors and polyps), to the nose (discoid lupus, mucocutaneous pyoderma), to the toes (symmetric lupoid onychodystrophy,
pemphigus foliaceus), to the tail (hypothyroidism, vasculitis).
Pemphigus can be secondary to other autoimmune diseases.
Pemphigus symptoms vary between types and are not necessarily specific to the disease.
Pemphigus can't be cured and will require ongoing treatment and regular veterinary check - ups.
A wide variety of diseases can occur including
pemphigus (all forms) and lupus (local or systemic).
It can be permanent and may be associated with immune - mediated conditions such as systemic lupus,
pemphigus variations, etc..
Skin diseases abound in Doberman Pinschers — allergies, bacterial skin infections (pyoderma), lick granuloma, color dilution alopecia (very common in blue Doberman Pinschers), demodectic mange in Doberman puppies, follicular dysplasia, sebaceous adenitis, seborrhea,
pemphigus, vitiligo, calcinosis, and zinc - responsive dermatosis.
All of the greyhound specific texts and articles I've ever read refer to this autoimmune condition as «
pemphigus.»
While toenail
pemphigus / SLO is an oddball diagnosis in other breeds, it should go straight to the top of the list in greyhounds experiencing multiple nail loss.
Common causes of dog ear infection are water trapped in the ear, foreign material (grass awns), yeast, atopy (inhaled seasonal allergy), hypersensitivity to foods, bacteria, immune mediated or autoimmune diseases (
pemphigus foliaceus) or mites (Otodectes and Demodex).
So «
pemphigus» vs. «SLO» is unimportant and a matter of semantics; we are talking about the same clinical syndrome.
Properly, as one of the IDEXX pathologists explained it to me, SLO involves nails and so is the correct histopathological diagnosis, whereas
pemphigus involves footpads and interdigital skin.
Pemphigus / SLO as it occurs in the greyhound involves the nails only, there are no other systemic signs - though there may certainly be a poor appetite and / or lethargy associated with the chronic pain.
Comparative analysis of canine dermatophytosis and superficial
pemphigus for the prevalence of dermatophytes and acantholytic keratinocytes: a histopathologic and clinical retrospective study.
The most common AI diseases in Aussies are in order of frequency: Autoimmune thyroiditis (hypothyroidism), Inflammatory Bowel Disease, lupus, and
pemphigus.
In
pemphigus / SLO, the nails separate at the base and come off.
By far, in greyhounds, the most common reason for multiple nail loss from multiple feet is
pemphigus - aka symmetrical lupoid onchodystrophy (SLO).
If the skin problem is the same on both halves (bilateral symmetry) then possible causes include Hypothyroidism, hyperadrenocorticism or
pemphigus foliaceus (skin condition with scaling).
When the defective immune system targets the skin, the result can be
pemphigus, lupus, or vitiligo.
Dermatology American College of Veterinary Dermatology International Society of Veterinary Dermatopathology Histiocytic disease in pets
Pemphigus disease in pets Genetic testing for Ivermectin Sensitivity in Pets
pemphigus, inflammatory bowel disease, feline infectious peritonitis, immune - mediated hemolytic anemia) What dogs / cats should not take this medication?
Unfortunately the breed is prone to several diseases like cataracts, glaucoma, entropion, diabetes,
pemphigus, and hip dysplasia.
The flea / tick preventative Promeris Duo for dogs and cats has been proven to cause
Pemphigus foliaceus, an autoimmune disease.
Therapeutic plasmapheresis is effective and often life - saving for the treatment of acute forms of immune - mediated diseases, as IMHA, Myasthenia Gravis, and
Pemphigus.
There are conditions where medications like cyclosporine may be mandatory, like
pemphigus or autoimmune anemias But it is certainly not mandatory for itchy dogs.
From
Pemphigus in Dogs to more information on Dog Diseases and Conditions To Dog Health Guide Home
In order to tell what subtype of
Pemphigus is causing your dog's blistering; the vet will do a biopsy.
The goal of dog
pemphigus treatment is to stop the bodies destructive immune skin response.
Lastly, an animal can suffer from an auto - immune disease of the skin (
pemphigus), in which the immune system goes haywire and mistakes skin cells for enemy invaders.
The most common form is
Pemphigus foliaceus, which tends to surface in Dachshunds, Bearded Collies, Dobermans, Schipperke, Finish Spitz, Rotties, Chows and Newfoundland dogs.
Approximately 50 % of dogs with
pemphigus foliaceus and
pemphigus erythematosus can be kept symptom free.
In the most common type of
pemphigus, pus - filled sores - which eventually break and form crusts - develop on the foot pads, bridge of the nose, and ears.
Pemphigus in dogs is most difficult to deal with since it is an autoimmune disease.
«The auto - immune disease
pemphigus in dogs has four types:
Pemphigus foliaceus,
pemphigus vulgaris,
pemphigus erythematosus and
pemphigus vegetans.
They have some pretty serious health problems like cataracts, glaucoma, eyelids that roll inwards (entropion), hip dysplasia, diabetes, and some autoimmune diseases like
pemphigus.
While
Pemphigus vegetans «may» be a slightly less severe form of
Pemphigus vulgaris, it looks different, which is what ultimately distinguishes it from vulgaris.
These types of products are used to help the body help itself through formulations that support the natural healing of the skin during recovery and to maintain skin and coat condition after recovery from
pemphigus in dogs.
Typically, the type of
pemphigus is diagnosed by what layer of the skin it affects.
Unfortunately, there are several «other» diseases that look like
Pemphigus and it's difficult to always get an accurate diagnosis.