Sentences with word «pentapeptide»

A parallel study was performed focusing on the exploration of amino acid residues of cyclic pentapeptides by systematic substitutions of various aromatic amino acid residues [62].

Structure - activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds.

Both amino and carboxyl termini face the cytoplasm, with the latter containing ten copies of a tyrosine - rich pentapeptide repeat.

The amide hydrogen within the Arg3 - Nal4 of FC131 was shown to be necessary for the ligand - CXCR4 interaction, giving important suggestions for the design and the development of novel cyclic pentapeptide based CXCR4 antagonists.

Previous SAR studies on pentapeptides showed that at least three functional groups on the peptide side - chains are required: an aromatic ring (such as 2 - naphthyl - or 3 - indolyl group), one or two guanidino groups, and a phenol group.

The subsequent pharmacophore approaches used for further molecular - size reduction led to the identification of cyclic pentapeptides containing these indispensable amino acids.

This was also confirmed by the structural elucidation of the pharmacophoric groups in the dimers and with a comparison of the dimeric scaffold to the oligomer polyphemusin II structure that was used for the design of the first cyclic - pentapeptide derivatives and by recent molecular modeling studies using the CXCR4 crystal structure [11].

This foundation contains SPF 15 and matrixyl pentapeptide, which helps stimulate collagen production, says Dr. Jaliman.

The exclusive hi - tech mascara formula contains the same lash - boosting peptide (myristoyl pentapeptide - 17) that's found in the original Eye Booster ™ 2 - in - 1 Lash Boosting Eyeliner + Serum and Eye Booster ™ Felt Tip Eyeliner + Serum to visibly enhance natural lash growth and appearance of lashes!

Doctors recommend pentapeptides (called Matrixyl on ingredient labels) and copper peptides.

The collagen boost comes from hexapeptides, pentapeptides wrapped up in alkylamides and spilanthes acmella.

Structure - activity relationship study of CXCR4 antagonists bearing the cyclic pentapeptide scaffold: identification of the new pharmacophore.

A recent study focused on the design of novel non-peptide CXCR4 antagonists based on the SAR and conformational studies of cyclic pentapeptides (Figure 8)[84].

Structure - activity relationship study on artificial CXCR4 ligands possessing the cyclic pentapeptide scaffold: the exploration of amino acid residues of pentapeptides by substitutions of several aromatic amino acids.

These results suggest an improved activity of amidine containing compounds due to a higher flexibility when compared with former cyclic pentapeptides.

Structures of select cyclic pentapeptide - based CXCR4 antagonists.

For example, the replacement of an Arg residue with the epimeric N - methyl - D - arginine led to the identification of the cyclic pentapeptide - based CXCR4 antagonist FC122 (4) that shows a significant enhancement of CXCR4 antagonistic activity (Figure 5)[11, 66, 69, 70].

Structures of representative examples of a monomeric cyclic pentapeptide - based CXCR4 antagonist, two dimeric derivatives and a dimeric Ga - labeled DOTA complex [81].