Sentences with phrase «peptide side chains»

Now, a team led by Zhengzhong Shao of Fudan University in China report that introducing peptide side chains into the polymer gives fibres that are strong and exhibit a remarkably rapid color change even at temperatures up to 200 °C.

Not exact matches

Both substrate analogs are contacted exclusively by conserved ribosomal RNA (rRNA) residues from domain V of 23S rRNA; there are no protein side - chain atoms closer than about 18 angstroms to the peptide bond being synthesized.

Previous SAR studies on pentapeptides showed that at least three functional groups on the peptide side - chains are required: an aromatic ring (such as 2 - naphthyl - or 3 - indolyl group), one or two guanidino groups, and a phenol group.

These compounds include some features of the polyethylene - hexamethylene biguanide NB325, as well as the peptide T140 that has five guanide groups on the side chains of arginine residues.

Structure - activity relationships of cyclic peptide - based chemokine receptor CXCR4 antagonists: disclosing the importance of side - chain and backbone functionalities.

Due to the free rotation of the side - chains, it was not straightforward to define the mutual spatial relationships among the functional groups, although previous studies had reported the fixed distances between Cβ atoms substituted with key functional groups on the rigid cyclic peptide nucleus.

The replacement of the Arg3 - Nal4 peptide bond with an (E)- alkene isostere in compound 7 produced a negative effect on CXCR4 inhibitory activity, probably due to the lack of H - bonding of amide moiety and a different interaction of pseudo -1,3-allylic strain between the Arg3 carbonyl group and the Nal4 side chain.

The side chain of D -[NMe] Orn2 represents, within the peptide, the «least important residue», amenable to acylation, and therefore it has been used as an anchor point for dimerization, leading to derivative 33 (Figure 7)[81, 83].