To validate their computer modeling predictions, researchers performed experiments in human cancer cell lines, mouse liver samples and primary human hepatocytes.
mRNA levels of the CYP4F gene cluster were quantified in humanliver samples (n = 149) obtained from a well - characterized liver bank and fine mapping of the CYP4F gene cluster encompassing CYP4F2, CYP4F11, and CYP4F12 was performed.