Sentences with phrase «peripheral effects of opioids»
They began a series of studies looking at the many peripheral effects of opioids and the potential benefits of blocking those effects.
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A study in rats published August 25 in Cell Reports suggests that a different approach that targets delta opioid receptors on sensory neurons in peripheral tissues might avoid the side effects and high abuse potential of currently available pain relievers.
Moreover, rats with reduced GRK2 levels in peripheral sensory neurons regained sensitivity to the pain - relieving effects of a drug that activates delta opioid receptors without the need for an inflammatory trigger.
«Being able to increase the responsiveness of peripheral opioid receptor systems could lead to a reduction in systemic opioid administration, thereby reducing the incidence of side effects.»
This drug, marketed as Relistor ™, was designed to block the peripheral side effects of opioids, such as nausea and constipation, without disrupting pain relief, which occurs in the brain.