Titled «
Peripheral Hypersensitivity to Subthreshold Stimuli Persists after Resolution of Acute Experimental Disc - Herniation Neuropathy and Is Mediated by Heightened TRPV1 Receptor Expression and Activity,» the study promises to shed light on the basis of neuropathic pain that persists after apparently successful surgery.
«For translation to humans, it would be important to know if pharmacological enhancement — ideally of the specific GABA receptor — can alleviate
the peripheral hypersensitivity to touch, especially in young children who may be in a critical period of vulnerability,» says Takao Hensch, a neuroscientist at Harvard University who was not involved in the research.
Not exact matches
On the flip side, mice that were genetically unable to produce BH4 in their sensory nerves had decreased pain
hypersensitivity after
peripheral nerve injury.
«By engineering mice that have these mutations only in their
peripheral sensory neurons, which detect light touch stimuli acting on the skin, we've shown that mutations there are both necessary and sufficient for creating mice with an abnormal
hypersensitivity to touch.»