Sentences with word «peroxynitrite»

However, nitric oxide production produces adverse reactions and toxic metabolites, which must be neutralized by your body so they don't result in oxidative damage to your blood vessel lining (by peroxynitrite oxidation and nitration reactions).

In the body, excessive NO facilitates the creation of the most damaging free radical, a prooxidant known as peroxynitrite.

ROS such as Nitric oxide, superoxide and peroxynitrite induce inflammation and at higher levels damage cells, and are implicated in chronic disease (r).

[35] Additional animal studies confirm that cyanidin is four times more powerful an antioxidant than vitamin E. [36] The anthocyanin pelargonidin protects the amino acid tyrosine from the highly reactive oxidant peroxynitrite.

Excess NO bioavailability is known to promote peroxynitrite generation, thereby triggering mechanistic side - effects resembling those of vascular oxidative stress [27].

Upon mechanical loading, NO reacts with superoxide to generate peroxynitrite.

However, it is gamma tocopherol (not the alpha form) that quenches peroxynitrite, the free radical that plays a major role in the development of age - related decline.101

Natural products containing hydroxy and methoxy groups effectively scavenge peroxynitrites and paritally reverse the damage they do to enzymes, transport systems, and receptors involved in short - term memory.

Alzheimer's disease is caused by a toxic oxidant called peroxynitrite.

Elevation of gamma tocopherol is of particular importance because gamma tocopherol, but not alpha tocopherol, quenches a particularly dangerous type of free radical (peroxynitrite radical) that plays a major role in the development of age - related disorders.

Superoxide anions can increase peroxynitrites, and also levels of the pro-inflammatory chemical interleukin - 8.

... and furthermore, the study found that the superoxides reacted with the gas nitric oxide to form peroxynitrites.

The following IL - 8 and peroxynitrite accumulation never happened.

They observed the antioxidant activity of blackberry juice on vascular tissue damaged by free radicals induced by peroxynitrite, an oxidant that can damage or destroy DNA and cells.

6 - Gingerol is a compound that has been significantly shown to inhibit the generation of nitric acid, a highly reactive nitrogen molecule that is quickly converted into a dangerous free radical known as peroxynitrite.

These free radicals (such as: superoxide, hydroxyl radical, and peroxynitrite) are controlled by antioxidant systems and when these systems can't cope with the amount of free radicals produced these free radicals scavenge for electrons from proteins, cell membranes, and DNA.

Nitric oxide, superoxide and peroxynitrite have also been implicated as responsible for the mitochondrial dysfunction apparent as early as three days after immunisation in excised tissue23, and we have confirmed the mitochondrial dysfunction at early days in vivo (data not shown), a time when inflammatory cells are very few in number, if present.»

LA scavenges hydroxyl radicals, hypochlorous acid, peroxynitrite, and singlet oxygen.

Peroxynitrites are like the notorious synthetic nitrites added to bacon (always buy an organic brand) which lead to stomach cancer, except that they're on your face wreaking acne havoc.