Sentences with word «phage»

To the best of Skurnik's knowledge, corresponding studies on the application of phages in food treatment have not been conducted anywhere prior to this.

The technology developed could be applied to bacteriophages with different morphologies to be used in phage therapy, in both animals and humans.

It seems at least plausible that part of any beneficial effect of faecal transplants may come from phages in the transplanted stool destroying C. difficile, rather than from direct competition by colonising bacteria.

There was some variation in the abundance of phages from healthy bladders vs. those isolated from women with symptoms of urinary tract infections.

Using phages for magnetic separation would be «really nice for food and environmental samples because they tend to be really dirty,» said Michael Wiederoder, a bioengineer at the U.S. Army Natick Soldier Research, Development and Engineering Center in Massachusetts, who was not involved in the research.

There is considerable interest in using phages as diagnostics and therapeutics of multi-drug resistant (MDR) bacteria.

D'Herelle's treatment came to be known as phage therapy.

Around that time, a colleague of ours at UC San Francisco said that a friend of hers had been treated with phage therapy in Tbilisi, Georgia.

PuLSE: Quality control and quantification of peptide sequences explored by phage display libraries — Steven Shave — PLOSone

Incorporating a synthetic phage genome into Gram - positive bacteria has so far been very problematic, as their cell walls are so thick.

Around the same time that transgenic mice began to be used to produce human antibodies, scientists also started employing a genomic technology called phage display to build massive libraries of human antibody genes that could be screened quickly.»

«Phages do not pose a risk to humans because they can only infect bacteria.

Methods: A novel human mAb, IRAB - A, was identified by phage screening using competition binding and surface plasmon resonance assays with the IR extracellular domain.

Camilli's research is part of a scientific renaissance into phage therapy, virtually unheard of in the West.

In January, for example, the National Institutes of Health announced a batch of grants to fund studies on phage therapy.

«In Finland, there is no urgent need to prevent Yersinia infections, but our study can serve as a model for the prevention of other, more serious foodborne infections through phage treatment,» says Skurnik.

Then, the researchers tracked how well the bacteria resisted phage attacks when various genes in a family were deleted.

The food industry and also hospitals may choose disinfectants that are active against bacteria, but might be ineffective against phages.

For example, specially targeted phages have been suggested as a possible therapy for conditions like cystic fibrosis, which is caused by frequent bacterial lung infections.

The impact of the microbiota on bone marrow transplantation in mice, differences in phage infection efficiency in nearly identical hosts, bacterial diversity of Brazilian artisanal cheese.

With no candidate targets, the team took an objective approach by applying a peptide phage library to MDSCs, which permitted mass screening for candidate peptides — short sequences of amino acids — that bind to the surface of the MDSCs.

Because phages are naturally found on fruits and vegetables and do not affect the odor, taste, safety or appearance of foods, scientists are investigating whether these «bacteria - eaters» could have an expanded role in promoting food safety.

Lyophilized engineered phages for Escherichia coli detection in food matrices.

Drugs that mimic phage proteins could similarly break down bacteria, Young says.

The methodology developed allows encapsulating bacteriophages of different sizes and morphologies, demonstrates the advantages of using encapsulated bacteriophages for oral phage therapy and, moreover, the nanometric size allows adding it to potable water and fodder.

To test the viability of these sequences, the investigators selected one of the 181 bacterial genomes, and found that they were able to induce one of several phage sequences within that genome to reproduce.

Scientists had long wondered how Q Beta and other small phages eliminate bacteria.

«The food safety preparations, the possible acne treatment, these are all potential icebreakers — incremental steps toward acceptance of phage therapeutics,» says Graham Hatfull, a biology professor and co-director of the University of Pittsburgh Bacteriophage Institute.

New phages multiply inside and eventually burst through the bacterium, killing it.

«The long - term evolutionary interaction between phage and bacteria has allowed us to identify targets that bacteria can not easily change or circumvent.

Hilbert and her colleagues isolated phages from 50 chicken samples purchased from Austrian supermarkets, street markets and butchers.

FLORASSIST GI with Phage Technology provides a probiotic blend to promote the growth of healthy bacteria in the intestines.

Now, the team has found that another type of dwarf phage also targets a gene responsible for a cell wall - building enzyme.

The researchers also investigated different mechanisms that could be behind the changing microbial populations and found evidence of the action of four ecological processes: ingestion of bacteria on food, the presence of abnormal oxygen levels in the gut, the availability of carbohydrates and other nutrients, and the presence of bacteria - infecting phage viruses.

It turned out that the resistant sheep harbored a virus called a bacteriophage, or simply phage, that specifically preys on E. Coli bacteria.

He conducted phage research until the collapse of the Soviet Union in 1991.

Using this technique, they looked for extrachromosomal phages across 24 medically important strains of Staphylococci.

AmpliPhi and Adaptive Phage Therapeutics have successfully treated more than two dozen patients with life - threatening conditions and are currently treating a few others under an emergency use authorization granted by the US Food and Drug Administration.

«We're taking advantage of what phage have «learned» during this period for us to identify new antibiotic targets that we believe will escape the problem of resistance found for other antibiotics.»

The investigators found a total of 457 mostly novel phage sequences in the urinary microbiome.

Last month they won first place in the Community College Innovation Challenge (CCIC) for their project, which uses tailormade viruses called bacterial phages to help hospitals combat the growing issue of antibiotic resistance.

They're delighted that Khodadoust is doing well, but they don't want to draw too many lessons about phage therapy from a single case.

There he became introduced into bacteriophage physiology and genetics thanks to intensive contacts that the former physics Professor Jean Weigle provided with the American phage group.

He was a postdoctoral scientist at Applied Molecular Evolution, where he produced and screened random peptide phage display libraries with soluble empty mouse CD1 (mCD1) to identify a peptide - binding motif for MHC Class I like receptors.

The reality, however, is that almost as soon as they divide and make baby bacteria, phages break them open, spilling their guts, and they start turning into carbon dioxide.

Earlier this year, a team led by microbiologist Ry Young of Texas A&M University in College Station showed that an especially tiny type of phage blocks a bacterial enzyme that builds cell walls.

This enables scientists to genetically modify phage genomes systematically, provide them with additional functionality, and finally reactivate them in a bacterial «surrogate» — a cell - wall deficient Listeria cell, or L - form.

Phage elements, including those not integrated into chromosomes, are part of a bacterial system for regulating genes.

Timed with the hundredth anniversary of their discovery, a new review published in the British Journal of Pharmacology examines the challenges and opportunities of developing phages as health - promoting, commercially - viable biopharmaceuticals.