Sentences with phrase «phage display»
"Phage display" refers to a scientific technique that uses viruses called phages to showcase and find specific proteins or antibodies. Essentially, it is like putting up a billboard (the phage) to exhibit different molecules and see if they can bind with and recognize a desired target. Full definition
PuLSE: Quality control and quantification of peptide sequences explored by phage display libraries — Steven Shave — PLOSone
microbiomedigest.com
On the other hand, the use of directed mutational activity has long been a tool of protein evolution whether e.g. it is in vitro via ribosomal display or in vivo via the use of bacterial mutator strains or via an in vitro / in vivo combination of error prone PCR followed by phage display.
Together with CSL we embarked on a collaborative project aiming to identify novel antibodies to target melanoma cells using phage display technology.
4.4 Technologies for Generation of TCRL Antibodies 4.4.1 TandAb 4.4.2 BiTE 4.4.3 E-Alpha Phage Display 4.4.4 HuTARG Protein Engineering 4.4.5 MAR & TriTE 4.4.6 TCRL Antibodies 4.4.7 TCRm Antibodies 4.4.8 Ylanthia Fab library 4.4.9 TCRL ADCs
Around the same time that transgenic mice began to be used to produce human antibodies, scientists also started employing a genomic technology called phage display to build massive libraries of human antibody genes that could be screened quickly.»
To identify a candidate AS AFFITOME vaccine antigen for initial animal testing, the investigators used mABs targeting the C - terminus of AS to screen phage display libraries, seeking peptides to which such Abs would bind (and thus potentially capable of inducing the generation of Abs targeting the original AS terminus when used as vaccine antigens).
We have identified a number of peptides that bind to Eph receptors and inhibit ephrin binding by using phage display approaches.
Liu J, Lubelski D, Schonberg D, Wu Q, Hale J, Flavahan W, Man J, Hjelmeland A, Yu JS, Lathia J, Mulkearns - Hubert E, Rich JN, Phage Display Discovery of Novel Molecular Targets in Glioblastoma Initiating Cells.
He was a postdoctoral scientist at Applied Molecular Evolution, where he produced and screened random peptide phage display libraries with soluble empty mouse CD1 (mCD1) to identify a peptide - binding motif for MHC Class I like receptors.
In this proposal we set out to utilize our canine - derived scFv phage display platform technology to isolate canine antibody fragments that bind and neutralize Vascular Endothelial Growth Factor (VEGF).
Techniques: phenotypic and functional analysis of tumor, fibroblasts, B and T, DCs and NK cells by multi-parametric flow cytometry, ELISPOT, LUMINEX, RNAseq, phage display....