Sentences with phrase «phage genome»

Incorporating a synthetic phage genome into Gram - positive bacteria has so far been very problematic, as their cell walls are so thick.

Students in the program learn to isolate and characterize bacteriophages, annotate the phage genomes, and then submit the sequences to a national database.

This enables scientists to genetically modify phage genomes systematically, provide them with additional functionality, and finally reactivate them in a bacterial «surrogate» — a cell - wall deficient Listeria cell, or L - form.

Not exact matches

It's developing a machine - learning algorithm that uses data from the genomes of both phages and bacteria.

«We found that lysogenic phages [phages that insert their DNA into the genomes of their hosts] are abundant within the bacteria of the bladder,» said Dr. Putonti.

To test the viability of these sequences, the investigators selected one of the 181 bacterial genomes, and found that they were able to induce one of several phage sequences within that genome to reproduce.

Sometimes, however, phages insert their own genetic material into a host's genome, then lie dormant until a trigger causes them to reawaken and multiply later.

When levels of arbitrium build up — after a large number of cells have died — phages stop killing off the remaining bacteria and retreat to lie dormant in bacterial genomes instead.

That changed what the phage did: it was now more likely to slip its genome into the bacteria, rather than kill it.

Bellen and Venken attached artificial docking sites to phages — a virus that targets bacteria — which they introduced in both the bacteria and in the fruit fly genomes to act as sticky points for the DNA segment being implanted in the latter's genome.

Related sites Web site for the Department of Energy program that supports Venter and other genome - related projects Series of lectures on the biology of phages (PDF)

They also noticed that the new virus, named Bacillus phage Tsamsa, is unusually large, with a giant head, a long tail and a large genome, placing it among the largest known bacteriophages.

For example, a gene was only integrated into an existing genome in a tiny fraction of the phages.

The loxP sequence does not occur naturally in any known genome other than P1 phage, and is long enough that there is virtually no chance of it occurring randomly.

After the last coffee break Emmanuelle Charpentier (Umeå University, Sweden) entered the scene and shared her knowledge about how to use phages (viruses that target bacteria) for genome engineering via CRISPRs.