The impact of the microbiota on bone marrow transplantation in mice, differences in
phage infection efficiency in nearly identical hosts, bacterial diversity of Brazilian artisanal cheese.
In other words,
the phage infection is self - limiting.
Not exact matches
Patients in danger of dying from uncontrollable bacterial
infections could find new allies: killer viruses known as
phages.
«We can sequence a
phage quickly and say, this is the exact DNA sequence we want,» says Paul Grint, CEO of AmpliPhi Biosciences, a startup that is concocting combinations of
phages in advance to treat bacterial
infections like Staphylococcus aureus.
«
Phage have been used as an alternative to antibiotics for decades in eastern European countries, particularly for treatment of urinary tract
infections,» said corresponding author Catherine Putonti, PhD, Associate Professor of Bioinformatics, Loyola University, Chicago.
The antibiotic, Epimerox, targets weaknesses in bacteria that have long been exploited by viruses that attack them, known as
phage, and has even been shown to protect animals from fatal
infection by Bacillus anthracis, the bacteria that causes anthrax.
There was some variation in the abundance of
phages from healthy bladders vs. those isolated from women with symptoms of urinary tract
infections.
Phage therapy, which exploits the ability of certain viruses to infect and replicate within bacteria, shows promise for treating antibiotic - resistant bacterial
infections.
The comeback of antibiotic - resistant
infections «would dramatically alter the practice of medicine,» says microbiologist Alexander Sulakvelidze, a
phage expert at the Emerging Pathogens Institute at the University of Florida in Gainesville.
A handful of desperate Americans — struggling with treatment - resistant
infections, diabetic ulcers or other chronic wounds — have journeyed to a clinic in Tbilisi, Georgia, for the «
phage miracle cure.»
It might be possible to follow up
phage therapy with antibiotics and completely wipe out an
infection.
In 2006, Intralytix secured FDA approval for ListShield, a cocktail of six
phages that is sprayed onto ready - to - eat meat and poultry (like you'd find at the deli counter) to control Listeria, which can cause a serious
infection (Listeriosis) that has a 20 percent fatality rate.
Oral
phage therapy has demonstrated to be a feasible and effective tool in the control of
infections caused by different bacterial pathogens.
Phages, shown here surrounding and attacking a bacterial cell, are part of a newly discovered type of immunity that protects mucus - covered human tissue from bacterial
infection.
For example, specially targeted
phages have been suggested as a possible therapy for conditions like cystic fibrosis, which is caused by frequent bacterial lung
infections.
Also presented are possible alternative approaches to tackling
infections, such as
phages (viruses that kill bacteria) sourcing new antibiotic leads from oceans, soils and host - associated microbiomes in humans, komodo dragons and leafcutter ants.