"Phage therapy" is a medical approach that uses viruses called phages to treat bacterial infections. These viruses specifically target and kill harmful bacteria, acting like a natural enemy to fight against the infection and help people get better.
Full definition
Lastly, by creating a generalizable standardized process to obtain phages, we may broaden the horizon for new exploration of novel phages and advances
in phage therapy of any MDR pathogen.
Original article: Colom J, Cano - Sarabia M, Otero J, Cortés P, Maspoch D, Llagostera M. «Liposome - Encapsulated Bacteriophages for Enhanced
Oral Phage Therapy Against Salmonella.»
It might be possible to follow up
phage therapy with antibiotics and completely wipe out an infection.
Carl said that the day Tom woke up from his coma
after phage therapy began was the happiest day in his career.
They're delighted that Khodadoust is doing well, but they don't want to draw too many lessons
about phage therapy from a single case.
«This first step in the characterization of the phages already present within the bladder has the potential to identify candidates for
subsequent phage therapy clinical studies for urinary symptom treatment.»
So -
called phage therapy is widely used in Eastern Europe and is currently undergoing one U.S. clinical trial.
Further down the line, he says, this could be harnessed for
personal phage therapy, where specially designed bacteriophages can be inserted into the gut to kill or boost certain bacterial populations that have gone awry.
And
despite phage therapy's apparent success, its proponents had not done enough to prove that it was reliably safe and effective.
In January, for example, the National Institutes of Health announced a batch of grants to fund studies
on phage therapy.
After the fall of communism, some ex-Soviet researchers
brought phage therapy to the West, where it attracted more curiosity this time.
Camilli's research is part of a scientific renaissance
into phage therapy, virtually unheard of in the West.
«Whilst
regulated phage therapy may take some time, it has been highly successful in recent «compassionate» cases where patients» lives were on the line,» said Dr. Forde.
The work was published recently in the journal Applied and Environmental Microbiology and is part of the PhD thesis with international mention by Joan Colom Comas entitled «Studies of the Molecular features of Three Salmonella Phages for Use
in Phage Therapy and of Encapsulation Methodologies to Improve Oral Phage Administration.»
Scientists at the Universitat Autònoma de Barcelona (UAB) and the Catalan Institute for Nanoscience and Nanotechnology (ICN2) have developed a nanoencapsulation system with a liposome coating in order to increase the efficacy of bacteriophages in
oral phage therapy.
As a result,
phage therapy is now used only for the sickest patients, as a treatment of last resort.
If the new approaches work,
phage therapy could eventually become a mainstream option for treating bacterial infections.
Phage therapy, which exploits the ability of certain viruses to infect and replicate within bacteria, shows promise for treating antibiotic - resistant bacterial infections.
Professor Mikael Skurnik from the University of Helsinki has studied bacteriophages and
phage therapy for a long time.
Turner has been studying bacteriophages for over two decades, and in recent years he's been investigating how to apply what he's learned to
phage therapy.
The widespread use of phages to kill foodborne pathogens may help overcome regulatory reluctance to
phage therapy.
Phage therapy might work where antibiotics failed.
Fortunately, there are signs that
phage therapy is going to get some of the attention it will need to become a regular part of medicine.
Five weeks after
the phage therapy, a tiny spike of bone poked into Khodadoust's fistula, causing massive bleeding.
Phage therapy is not approved for regular use by the Food and Drug Administration.
Oral
phage therapy has demonstrated to be a feasible and effective tool in the control of infections caused by different bacterial pathogens.
The methodology developed allows encapsulating bacteriophages of different sizes and morphologies, demonstrates the advantages of using encapsulated bacteriophages for oral
phage therapy and, moreover, the nanometric size allows adding it to potable water and fodder.
The technology developed could be applied to bacteriophages with different morphologies to be used in
phage therapy, in both animals and humans.
Patterson: I wasn't really aware of
the phage therapy until I woke up.
Around that time, a colleague of ours at UC San Francisco said that a friend of hers had been treated with
phage therapy in Tbilisi, Georgia.
And
the phage therapy has really been a miracle for me, and to, to say that it might mean that millions of people are cured from this in the future is really a privilege.
So after a little bit of reading, it became clear that (
phage therapy) was worth trying.
(But)
phage therapy was stalled in terms of individuals like Tom.