Sentences with phrase «phages for»

The success of this study may provide the foundation for an improved program for high school students to foster their interest in research and gain invaluable experiences outside of the classroom while providing bacteriophages that can serve as the base chassis of synthetically engineered phages for diagnosis and treatment of MDR pathogens.

The work was published recently in the journal Applied and Environmental Microbiology and is part of the PhD thesis with international mention by Joan Colom Comas entitled «Studies of the Molecular features of Three Salmonella Phages for Use in Phage Therapy and of Encapsulation Methodologies to Improve Oral Phage Administration.»

For eons, bacteria have battled particularly tiny viruses called bacteriophages, or phages for short, which infect and kill bacteria but leave humans and other animals alone.

Hilbert recommends to test therapeutic phages for their ability to transfer resistance genes.

Under a Cooperative Research and Development Agreement — or CRADA — with USDA, the Baltimore - based company Intralytix is supplying the phages for the trials.

Not exact matches

That, combined with the time it takes to transport a phage to a hospital, can be too long for some patients, says CEO Greg Merril: «When a patient is critically ill, every minute is important.»

As a result, phage therapy is now used only for the sickest patients, as a treatment of last resort.

For now, Adaptive Phage Therapeutics plans to use the AI system at its Maryland office to determine the best course of treatment for a patient, choose the right phage from its collection, and send the phage to the hospitFor now, Adaptive Phage Therapeutics plans to use the AI system at its Maryland office to determine the best course of treatment for a patient, choose the right phage from its collection, and send the phage to the hospPhage Therapeutics plans to use the AI system at its Maryland office to determine the best course of treatment for a patient, choose the right phage from its collection, and send the phage to the hospitfor a patient, choose the right phage from its collection, and send the phage to the hospphage from its collection, and send the phage to the hospphage to the hospital.

For example, the phages exposed E. coli in milk and orange juice by turning the liquids red or pink.

«This first step in the characterization of the phages already present within the bladder has the potential to identify candidates for subsequent phage therapy clinical studies for urinary symptom treatment.»

«Phage have been used as an alternative to antibiotics for decades in eastern European countries, particularly for treatment of urinary tract infections,» said corresponding author Catherine Putonti, PhD, Associate Professor of Bioinformatics, Loyola University, Chicago.

For example, phages are useful for selectively decontaminating cheese — a food that relies heavily on the presence of beneficial bacteria for its flavFor example, phages are useful for selectively decontaminating cheese — a food that relies heavily on the presence of beneficial bacteria for its flavfor selectively decontaminating cheese — a food that relies heavily on the presence of beneficial bacteria for its flavfor its flavor.

«This suggests that phage may contribute to urinary health and is an exciting new avenue for future research,» said Dr. Putonti.

«We're taking advantage of what phage have «learned» during this period for us to identify new antibiotic targets that we believe will escape the problem of resistance found for other antibiotics.»

Sorek's team was looking for evidence that a bacterium called Bacillus subtilis might alert other bacteria to phages.

Phage therapy, which exploits the ability of certain viruses to infect and replicate within bacteria, shows promise for treating antibiotic - resistant bacterial infections.

A phage means bacteria eater and so they were very specific hosts, which is a very specific bacteria, and we like these viruses a lot because they only have a couple different genes and those genes code for a couple different proteins and so they are easy for us to manipulate in the lab.

Next, the researchers inoculated kitchen utensils, such as wooden and plastic cutting boards, knives and surgical gloves, with the bacteria and phages, after which the number of bacteria and phages in the utensils was monitored for two hours.

The contaminated food was then subjected to phage treatment, after which the number of both bacteria and phages was monitored for three days.

Professor Mikael Skurnik from the University of Helsinki has studied bacteriophages and phage therapy for a long time.

Since phages have evolved with their bacterial targets for billions of years, they could solve the problem of antibiotic resistance for good; the downside is that each bacterial strain requires its own tailored phage cocktail, so it could be many years before doctors have a suitably broad range of phages at their disposal.

Further down the line, he says, this could be harnessed for personal phage therapy, where specially designed bacteriophages can be inserted into the gut to kill or boost certain bacterial populations that have gone awry.

Each strain of phage is highly targeted and has evolved to home in on specific bacteria, which means a precise match between prey and predator is necessary for any phage - based treatment to be effective.

Phages would require a less traditional approach to get official approval, such as the annual process for influenza vaccines in which manufacturers secure approval of new formulas based on the flu bug that is going around that year, instead of conducting big clinical trials every time.

However, the scientists note, for items with a more neutral pH, such as melon and cucumber slices, phage disinfection outperforms such commercially important sanitizers as chlorine.

Thats why the scientists are cooking up recipes for food - protecting cocktails of different phages.

For instance, phage disinfection does nt work well on acidic foods, such as apples or, presumably, tomatoes.

Indeed, the lack of any flavor in phage mists might even give them an advantage over alternatives — such as vinegar mists or chlorine baths — for sanitizing salad greens.

That company has been gaining renown for pioneering exploitation of phages to quash a host of food poisoning agents in other venues, such as meats (SN: 6/3/00, p. 358).

In January, the U.S. Department of Agriculture applied for a patent to sanitize plant products with phages.

A handful of desperate Americans — struggling with treatment - resistant infections, diabetic ulcers or other chronic wounds — have journeyed to a clinic in Tbilisi, Georgia, for the «phage miracle cure.»

Unraveling the underlying mechanism could help pave the way toward making phages a targeted therapy for diseases like cholera.

In 2006, Intralytix secured FDA approval for ListShield, a cocktail of six phages that is sprayed onto ready - to - eat meat and poultry (like you'd find at the deli counter) to control Listeria, which can cause a serious infection (Listeriosis) that has a 20 percent fatality rate.

«The phages clearly have gained the upper hand, and studying how they do it can eventually open the door for treating cholera with phages.»

John suggested to Fred that he use the phage as the training wheels for learning how to sequence DNA.

Bellen and Venken attached artificial docking sites to phages — a virus that targets bacteria — which they introduced in both the bacteria and in the fruit fly genomes to act as sticky points for the DNA segment being implanted in the latter's genome.

Phages were used for more than 75 years as therapy in Eastern Europe, but they fell out of favour in the western world when antibiotics were discovered.

Bacteriophages, or simply phages, are viruses that infect and replicate within bacteria, and they hold considerable potential for combatting antibiotic - resistance and other threats to human health.

Scientists have known for a while that phages are able to transduce genes but this was considered a rare event for genes encoding resistance to antibiotics.

Related sites Web site for the Department of Energy program that supports Venter and other genome - related projects Series of lectures on the biology of phages (PDF)

It attacked Pseudomonas through its pump, a molecule called outer - membrane - porin M. Chan dubbed the virus of his dreams OMKO1 (short for outer - membrane - porin M knockout dependent phage # 1).

With no candidate targets, the team took an objective approach by applying a peptide phage library to MDSCs, which permitted mass screening for candidate peptides — short sequences of amino acids — that bind to the surface of the MDSCs.

Engineered phage viruses show promise as targeted assassins - genetic manipulation might make it easier for them to gain regulatory approval

«It looks like small phages are a gold mine for protein antibiotics.»

«As bacteria's natural enemies, their potential as sources for ways to kill bacteria should have been thoroughly explored long ago, but it is only now, with the emerging worldwide crisis in antibiotic resistance, that phages are finally getting attention in their own right,» Ing - Nang Wang, another co-author on the report, remarks.

Ganz said that she hoped the publication of the phage's sequence information would enable other researchers to investigate further and potentially develop applications for the phage and its proteins.

Now, the team has found that another type of dwarf phage also targets a gene responsible for a cell wall - building enzyme.

But Hatfull says there are plenty of other, yet - unstudied phages whose strategies could be adapted for use in antibiotics.

Thus, the two small phages characterized for their lysis strategy, Qβ and the small DNA phage φX174, effect host lysis by targeting different enzymes in the multistep, universally conserved pathway of cell wall biosynthesis.

Scientists at the Universitat Autònoma de Barcelona (UAB) and the Catalan Institute for Nanoscience and Nanotechnology (ICN2) have developed a nanoencapsulation system with a liposome coating in order to increase the efficacy of bacteriophages in oral phage therapy.