Importantly, akin to HESC - RPE in vivo, cells at the outside edge of the iPS - RPE cell bolus could
phagocytose photoreceptor outer segments from the RCS rat, as indicated by the presence of rhodopsin - positive photoreceptor material within the cellular membrane of iPS - RPE labelled with HSM (Fig. 5E).
iPS - RPE are capable of
phagocytosing photoreceptor material, in vitro and in vivo following transplantation into the Royal College of Surgeons (RCS) dystrophic rat.
Not exact matches
In this well - studied model of autosomal recessive retinitis pigmentosa and secondary
photoreceptor degeneration, a MERTK mutation in the RPE compromises their ability to
phagocytose shed
photoreceptor outer segments [35]--[37].
iPS - RPE were able to
phagocytose fluorescently labelled porcine
photoreceptor outer segments (POS) in co-culture.
The location of transplanted human cells, their expression profile and ability to
phagocytose rod
photoreceptor material was examined in vivo using immunohistochemistry.