Sentences with phrase «phagocytosis of»

Immunocyctochemistry was also used to assess phagocytosis of host outer segments in vivo.

Phagocytosis of photoreceptor outer segments was defined by the inclusion of rhodopsin - labelled material within the TRA -1-85-bordered intracellular compartment of grafted human iPS - RPE cells.

Phagocytosis of fluorescently labelled photoreceptor outer segments (green) by iPS - RPE cells in vitro.

(A) Confocal images showing phagocytosis of isolated FITC - labelled porcine photoreceptor outer segments (POS — green) by iPS - RPE in culture.

The main mechanism includes phagocytosis of macrophages which play a critical role in nonspecific defense (innate immunity) and, moreover; they have a role as antigen presenters which also help initiate specific defense mechanisms (adaptive immunity) by recruiting other immune cells such as lymphocytes.

Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN - γ in a nitric oxide - dependent manner.

Mutations in two nonessential genes specifically block the phagocytosis of cells programmed to die during development.

Not exact matches

«We also demonstrated that the presence of CD47 on exosomes» allows for evasion from phagocytosis by the circulating monocytes.»

Within 10 minutes of the bacteria reaching the lungs, the neutrophils started to crawl toward the bacteria and gobble them up, a process called phagocytosis.

Since a protein called Rac1 is essential for normal milk production, as well as phagocytosis in immune cells, Nasreen Akhtar at the University of Sheffield and her colleagues wondered whether it might also be involved in this breast remodelling.

Here is the mystery: the body's immune cells usually remove dead and dying cells through a process called phagocytosis, yet the amount of material that is consumed is so great that you'd expect significant inflammation, pain and tissue damage — something that doesn't typically happen when breastfeeding ceases.

Indeed, they also use phagocytosis and DNA nets to exterminate bacteria that would jeopardize the survival of the slug.

Blocking the mechanisms involved in other methods of cell death including apoptosis and phagocytosis did not disrupt the process, confirming that entosis operates in a different way.

Injection of wild - type stage 15 embryos with E. coli constitutively expressing Mcf1 from the high - copy vector pUC18 causes rapid paralysis of embryonic hemocytes and inhibition of phagocytosis as observed following wild - type Photorhabdus infection (Figure 3A and Video S3).

This may be of particular importance in the ageing lung as pulmonary infections are the primary cause of morbidity and mortality in the elderly, as discussed by Boe et al. 11 Innate cells appear to have reduced TLR signalling via MAPK and NFƙB resulting in reduced inflammatory cytokine production as well as altered chemotaxis responses, decreased phagocytosis and antigen presentation capacity.

They found that the interaction of the C3dg fragments on affected erythrocytes and the binding domain for CR3 on immune cells can lead to phagocytosis and the rupturing of red blood cells in PNH patients.

Detection of gene repertoires related to ecological functions (phagocytosis, organic matter degradation, membrane transporters, meiosis) in different lineages of heterotrophic microeukaryotes.

«The novelty of our study is that the final state of this C3 coating, called C3dg, which has sometimes been described as a «safe harbor» against phagocytosis, can still mediate recycling of C3dg - laden cells,» Ricklin says.

MicroRNA - 34a - mediated down - regulation of the microglial - enriched triggering receptor and phagocytosis - sensor TREM2 in age - related macular degeneration.

Interestingly, p21 - null lymphomas exhibited a high level of apoptosis with tangible apoptotic bodies, often surrounded by a narrow halo indicative of phagocytosis (Fig. 4B) ⇓.

Molecular characterization of LC3 - associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins.

Mammary epithelial cell phagocytosis downstream of TGF - β3 is characterized by adherens junction reorganization.

The effects of macrophage source on the mechanism of phagocytosis and intracellular survival of Leishmania.

Targeting of Protein Kinase C - ϵ during Fcγ Receptor - dependent Phagocytosis Requires the ϵC1B Domain and Phospholipase C - γ1.

In addition, they put other parts of the immune system on alert and function as a clean - up crew, recognizing invading pathogens and gobbling them up, a process known as phagocytosis.

These include: 1) live viral vaccine neutralization by maternal Abs, 2) Ab feedback mechanisms, 3) elimination of vaccine - antigen / maternal Ab immune complexes by phagocytosis, 4) inhibition of B cell responses through epitope masking, and 5) inhibition of B cell responses by binding of IgG to the FcγRIIB (134, 135).

Flow cytometry is an evolving field with a wide range of applications that includes immunophenotyping, cell division and apoptosis, cell activation, intracellular pH shifts, phagocytosis, oxidative burst and much more.

These effects appear to be linked to progranulin's involvement in phagocytosis, a type of cellular house - keeping whereby cells «eat» other dead cells, debris, and large molecules.

Using the Mfrprd6 model, and others with similar protein localization and phenotypes when mutated, we hope to gain a better understanding of how RPE cells affect photoreceptor development and the process of phagocytosis.

(iii) Lipid deposits (L), a sign of late stage POS phagocytosis, are observed within the iPS - RPE cytoplasm after 12 h co-culture.

The appearance of RPE cell morphology was associated with the expression of a panel of classic RPE genes and proteins required for retinoid recycling (RPE65, LRAT, RLBP1), phagocytosis (FAK and MERTK) and melanogenesis (Tyrosinase, PMEL17 and MITF).

We used phagocytosis assays to assess the functional potential of cells.

For quantification of phagocytosis, alveolar macrophages were infected at an MOI of 20 for 1 h, then media was removed, extracellular bacteria were killed with gentamycin (200 μg / ml for 10 min at 37 C), and macrophages were lysed with 0.2 % triton X-100 (10 min at room temperature).

It also stimulates lymph system activity and phagocytosis, the process of cells cleaning house.

Probiotic supplementation has been shown to strengthen the activity of many cytokines — increasing interleukin (IL)-1 β and IL - 18 activates IFN - γ production from T, B, and Natural Killer Cells, which enhances phagocytosis (destruction) of pathogens.

So you can clearly see that regular, moderate exercise boosts the ability of the neutrophils to get to infection sites quickly (chemotaxis) and attack the bad guys (phagocytosis).

Garlic is thought to increase immune cells and strengthen them by inducing phagocytosis and promoting the activity of macrophages, which encourages white blood cells to fight infection and foreign organisms in the body.

It is also characterized by a cellular reaction focused on the use of neutrophils and macrophages to «clean up» the site through debridement, phagocytosis, matrix synthesis, and cell recruitment and activation.