Upon entering macrophages, most bacteria are enfolded into vesicles
called phagosomes.
EFF - 1 fusogen
promotes phagosome sealing during cell process clearance in Caenorhabditis elegans
These processes appear to be regulated by circadian rhythms and response to environmental light, such that the number
of phagosomes in the RPE is highest shortly after the onset of light.
But the blue strip in the middle contains bacteria that reside
in phagosomes, which for some reason are not being transformed into the degrading lysosomes.
The phagosome fuses with other vesicles that contain various decomposing substances.
Therefore, they suffer recurrent infections, since their immune system lacks the reactive oxygene species that kill bacteria inside
the phagosome or via DNA nets.
This vesicle is called
a phagosome and is the actual «executioner» in the cell.
Micro-injection of purified Mcf1 (0.2 mg / ml) into wild - type stage 15 Drosophila embryos containing GFP - moesin expressing hemocytes also triggers rapid freezing of hemocytes with «frozen» cellular protrusions and
phagosomes (Figure 3B and Video S4).
OS phagocytosis consists of a number of steps including recognition and binding, ingestion and formation of
phagosomes, and degradation.
Another point mutation in the gene coding for dynactin, which participates in the dynamic of
phagosomes, is responsible of fALS (40).