Sentences with phrase «pharmacokinetic parameters»

Knowledge of the pharmacokinetic parameters of chlorambucil in this population of older, cancer - bearing cats is critical to understand why some cats experience side effects with chlorambucil therapy and determine if variability in the metabolism of chlorambucil contributes to treatment failure.

Despite the wide use of chlorambucil in cats, the pharmacokinetic parameters (i.e. how the body absorbs, metabolizes and eliminates the drug) have not been previously studied in cats.

«Based on the variability of pharmacokinetic parameters and drug clearance, the two Vancomycin nomograms developed to predict therapeutic Vancomycin concentrations in healthy adults did not accurately estimate dosage regimens in older children regardless of weight or age, and therefore should not be used to aid empiric dosing,» said Dr. Jessica Gillon.

Not exact matches

Furthermore, the drug itself is distributed differently within the extracellular matrix of the tumor and the lung parenchyma, where several and different parameters influence the pharmacokinetics.