This study aims to describe
the pharmacokinetic profile of vinblastine in cats and to identify which characteristics or traits that can vary from one cat to another (e.g., age, kidney function, liver function) influence how vinblastine is distributed and eliminated in cats.
The Phase 1b / 2a study of ISIS - SMNRx is a multiple - dose, dose - escalation study designed to assess the safety, tolerability and
pharmacokinetic profile of the drug in children with SMA between the ages of 2 - 15 who are medically stable.
Pharmacokinetic profile of J147 in mice.
(A)
The pharmacokinetic profile of J147 in mice was done by Pharmaron (Louisville, KY, USA).
Since it is plausible that the unfavorable
pharmacokinetic profile of 182a is due to a rapid oxidative metabolism, a series of derivatives functionalized with electron deficient moieties on the terminal aromatic ring were synthesized.
The Phase 1 study of ISIS - SMNRx is a single - dose, dose - escalation study designed to assess the safety, tolerability and
pharmacokinetic profile of the drug in children with SMA between the ages of 2 - 14 who are medically stable.
Not exact matches
«This is exactly the
pharmacokinetic profile produced by lithium salicylate in our study,» said senior author Doug Shytle, PhD, also
of the Center
of Excellence for Aging and Brain Repair at USF Health.
According to Tomas Cihlar, Ph.D.,
of Gilead Sciences, the company is currently conducting phase I clinical studies
of the compound in healthy human volunteers to establish the safety and
pharmacokinetic profile.
Furthermore, in order to optimize the
pharmacokinetic profile and to improve CXCR4 binding affinity
of this class
of molecules, dual pyrimidinyl compounds, substituted with different functional groups such as methoxy and morpholine, were synthesized (compounds 194 - 200).
One key aspect that her research group has devoted its efforts to over the past 15 years is expanding the toolkit
of building blocks to include fluorinated aliphatic amino acids to improve the
pharmacokinetic and physicochemical
profiles of peptide / protein - based drugs and materials, respectively.
The ascending - dose, single - blind, placebo controlled, randomized trial will evaluate the safety as well as the
pharmacokinetic and pharmacodynamic
profile of DG041.
Proposed mechanisms
of action for each drug, and known
pharmacokinetic profiles in dogs are discussed.