Sentences with phrase «pharmacokinetic study»

Pharmacokinetic study of oral Ɛ - Aminocaproic acid in the Northern elephant seal (Mirounga angustirostris).

UC Davis veterinary resident Lionel Sebbag, Dr. Med Vet, conducted a large pharmacokinetic study of famciclovir.

With the exception of IK14 (0.1 — 0.26 μg / mL), the values obtained (0.98 — 1.87 μg / mL) were above or consistent with expected trough values derived from our previous pharmacokinetic study [38].

individual would be 1.47 mg / kg, but our pharmacokinetic study indicated that in macaques, a dose of 5 mg / kg is to achieve MIC levels in blood for over 80 % of the treatment duration of 12 hours.

The single pharmacokinetic study published on non-concentrate naloxone showed that only 4 % of naloxone is absorbed when administered nasally.

However, the double positive charge at the physiological pH precludes a complete absorption, as showed by preliminary pharmacokinetic studies.

Not exact matches

«This is exactly the pharmacokinetic profile produced by lithium salicylate in our study,» said senior author Doug Shytle, PhD, also of the Center of Excellence for Aging and Brain Repair at USF Health.

Studies in humans will be needed to confirm safety and demonstrate that the pharmacokinetic profile observed in rats is similarly observed in humans.»

Butler advises graduate students interested in industry to do two things: complete an internship at a company and make sure that they attend critical conferences related to drug metabolism and pharmacokinetics — such as the International Society for the Study of Xenobiotics.

CT - P13 has previously demonstrated pharmacokinetic (PK) equivalence to INX in the PLANETAS trial, a randomised double - blind, parallel group study of 250 patients with AS, and was recently approved by the European Medicines Agency.

According to Dr Won Park, Inha University Hospital, Korea, and lead investigator of the PLANETAS study, «the challenge for biosimilars is to demonstrate similarity in therapeutic effectiveness, safety and immunogenicity to their reference product, not just biochemical and pharmacokinetic equivalence.»

«Although it is well known that RYGB affects how the body handles alcohol, findings from earlier studies on the effects of sleeve gastrectomy on alcohol pharmacokinetics are contradictory.»

This study was a randomized, double - blind, placebo - controlled trial designed to characterize the safety, tolerability and pharmacokinetics of AVI - 7288 after daily repeat dosing.

The investigators are currently designing a study to correlate pharmacokinetics, the time course of drug metabolism, with genotype.

According to Tomas Cihlar, Ph.D., of Gilead Sciences, the company is currently conducting phase I clinical studies of the compound in healthy human volunteers to establish the safety and pharmacokinetic profile.

A Phase 1 / 2a Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of PLX8394 in Patients with Advanced, Unresectable Solid Tumors

The Phase 1 study of ISIS - SMNRx is a single - dose, dose - escalation study designed to assess the safety, tolerability and pharmacokinetic profile of the drug in children with SMA between the ages of 2 - 14 who are medically stable.

A Phase 1b / 2a Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of AMG 232 Combined with Trametinib and Dabrafenib or Trametinib in Adult Subjects with Metastatic Cutaneous Melanoma

A Phase 1b / 2 Open - Label Study to Evaluate Safety, Clinical Activity, Pharmacokinetics and Pharmacodynamics of Avelumab (MSB0010718C) in Combination with Other Cancer Immunotherapies in Patients with Advanced Malignancies

Establish infrastructure to test repurposed drugs in cell culture and animal models for potency, pharmacokinetic (PK), and pharmacodynamic (PD) studies.

The prototype of such bis - macrocycles, plerixafor, was used in a recent study as a starting point for structural modification, in order to identify compounds endowed with a similar antiviral activity and improved pharmacokinetic properties [94].

The second study, FIREFISH, is aimed to assess safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy in infants with Type I SMA.

An Open - Label Multicenter Phase 1 Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of H3B - 6527 in Subjects with Advanced Hepatocellular Carcinoma or Intrahepatic Cholangiocarcinoma

An Open - Label, Multicenter Phase I Study to Characterize the Safety, Tolerability, Preliminary Anti-Tumor Activity, Pharmacokinetics and Maximum Tolerated Dose of BAY 1251152 in Patients with Advanced Hematological Malignancies

A Multi-arm, Phase Ib, Open - Label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of AZD9291 in Combination with Ascending Doses of Novel Therapeutics in Patients with EGFRm + Advanced NSCLC who have progressed following therapy with an EGFR TKI (TATTON)

Safety, tolerability, and pharmacokinetic interactions of the antituberculous agent TMC207 (bedaquiline) with efavirenz in healthy volunteers: AIDS Clinical Trials Group Study A5267.

In a study published in a recent edition of Nano Letters, the Laboratory's Mike Malfatti, Heather Palko, Ed Kuhn and Ken Turteltaub report on accelerator mass spectrometry measurements used to investigate the relationship between administered dose, pharmacokinetics (PK), and long - term...

The Intestine Chip therefore may be useful as a research tool for applications where normal intestinal function is crucial, including studies of metabolism, nutrition, infection, and drug pharmacokinetics, as well as personalized medicine.

The randomized, double - blind, placebo - controlled study will evaluate the safety and tolerability of multiple doses of NPT088, as well as pharmacokinetics, immunogenicity and pharmacodynamic characteristics, as measured by Aβ and tau PET imaging.

In a study published in a recent edition of Nano Letters, the Laboratory's Mike Malfatti, Heather Palko, Ed Kuhn and Ken Turteltaub report on accelerator mass spectrometry measurements used to investigate the relationship between administered dose, pharmacokinetics (PK), and long - term biodistribution of carbon 14 - labeled silica nanopartocles in vivo.

In this study, NPT088 was safe and well - tolerated at multiple dose levels, with a suitable pharmacokinetic profile.

Phase I safety, pharmacokinetics, and pharmacogenetics study of the antituberculosis drug PA - 824 with concomitant lopinavir - ritonavir, efavirenz, or rifampin.

Studies determining Absorption, Distribution, Metabolism and Excretion (ADME) patterns in laboratory animals and humans are an integral part of the Drug Metabolism and Pharmacokinetics (DMPK) services provided by QPS.

Now, with the team's newly engineered human kidney glomerulus - on - a-chip, researchers also can get in vitro access to the kidney's core filtration mechanisms that are critical for drug clearance and pharmacokinetics, in addition to studying human podocytes at work.

The Phase 1b / 2a study of ISIS - SMNRx is a multiple - dose, dose - escalation study designed to assess the safety, tolerability and pharmacokinetic profile of the drug in children with SMA between the ages of 2 - 15 who are medically stable.

The purpose of this study is to evaluate the safety, pharmacokinetics, pharmacodynamics and clinical activity of AG - 120 in advanced hematologic malignancies that harbor an IDH1 mutation.

179/5: 00 Genome - wide association study of olanzapine pharmacokinetics.

This study established the MTD of the cyclophosphamide - huKS - IL2 combination (mainly limited by IL - 2 side effects), the pharmacokinetics of huKS - IL2 and its systemic immunologic and immunogenic effects in patients with solid tumors (BMC Cancer.

Since the proposed model may be used in further studies and the results of the study could be interpreted by people who are not familiar with the peculiarity of nicotine / cotinine pharmacokinetics in mice, we attempted to estimate the level of nicotine (and e-liquid vapor) exposure used in the discussed study.

Due to the sex - related disparities in pharmacokinetics and bioavailability results reported by different authors (Soldin, Chung, & Mattison, 2011; Soldin & Mattison, 2009), the choice of a single genus was chosen to avoid a high dispersion in the data, and the availability of healthy young adult female volunteers for the study.

This paper, Pharmacokinetics of acute tryptophan depletion using a gelatin - based protein in male and female Wistar rats summarizes what we find in a number of studies that use gelatin for the purpose of lowering serotonin levels, in order to study the relationship between serotonin and behavior:

New research published in November 2015: Study of GABA in Healthy Volunteers: Pharmacokinetics and Pharmacodynamics shows potential benefits for diabetes:

Pharmacokinetics and endometrial tissue levels of progesterone after administration by intramuscular and vaginal routes: a comparative study.

Pharmacokinetics of famciclovir and penciclovir in tears following oral administration of famciclovir to cats: a pilot study.

In 2016 Colorado State University (CSU) completed a study on safety, toxicity, and pharmacokinetics of cannabidiol in healthy dogs.

Despite the wide use of chlorambucil in cats, the pharmacokinetic parameters (i.e. how the body absorbs, metabolizes and eliminates the drug) have not been previously studied in cats.

This study aims to describe the pharmacokinetic profile of vinblastine in cats and to identify which characteristics or traits that can vary from one cat to another (e.g., age, kidney function, liver function) influence how vinblastine is distributed and eliminated in cats.

The purpose of this study was to describe the pharmacokinetics and pharmacodynamics of an extended - release buprenorphine (ERB) formulation in healthy adult dogs.

Few in vitro studies have provided bioavailability and pharmacokinetic data differentiating the most optimally absorbed glucosamine formulation in canines.»

She started out in the pharmaceutical industry, first conducting biopharmaceutical / pharmacokinetic animal model studies, and then monitoring animal health clinical trials.