Pharmacokinetic study of oral Ɛ - Aminocaproic acid in the Northern elephant seal (Mirounga angustirostris).
UC Davis veterinary resident Lionel Sebbag, Dr. Med Vet, conducted a large
pharmacokinetic study of famciclovir.
Not exact matches
«This is exactly the
pharmacokinetic profile produced by lithium salicylate in our
study,» said senior author Doug Shytle, PhD, also
of the Center
of Excellence for Aging and Brain Repair at USF Health.
Butler advises graduate students interested in industry to do two things: complete an internship at a company and make sure that they attend critical conferences related to drug metabolism and
pharmacokinetics — such as the International Society for the
Study of Xenobiotics.
CT - P13 has previously demonstrated
pharmacokinetic (PK) equivalence to INX in the PLANETAS trial, a randomised double - blind, parallel group
study of 250 patients with AS, and was recently approved by the European Medicines Agency.
According to Dr Won Park, Inha University Hospital, Korea, and lead investigator
of the PLANETAS
study, «the challenge for biosimilars is to demonstrate similarity in therapeutic effectiveness, safety and immunogenicity to their reference product, not just biochemical and
pharmacokinetic equivalence.»
«Although it is well known that RYGB affects how the body handles alcohol, findings from earlier
studies on the effects
of sleeve gastrectomy on alcohol
pharmacokinetics are contradictory.»
This
study was a randomized, double - blind, placebo - controlled trial designed to characterize the safety, tolerability and
pharmacokinetics of AVI - 7288 after daily repeat dosing.
The investigators are currently designing a
study to correlate
pharmacokinetics, the time course
of drug metabolism, with genotype.
The single
pharmacokinetic study published on non-concentrate naloxone showed that only 4 %
of naloxone is absorbed when administered nasally.
According to Tomas Cihlar, Ph.D.,
of Gilead Sciences, the company is currently conducting phase I clinical
studies of the compound in healthy human volunteers to establish the safety and
pharmacokinetic profile.
A Phase 1 / 2a
Study to Assess the Safety,
Pharmacokinetics, and Pharmacodynamics
of PLX8394 in Patients with Advanced, Unresectable Solid Tumors
The Phase 1
study of ISIS - SMNRx is a single - dose, dose - escalation
study designed to assess the safety, tolerability and
pharmacokinetic profile
of the drug in children with SMA between the ages
of 2 - 14 who are medically stable.
A Phase 1b / 2a
Study Evaluating the Safety, Tolerability,
Pharmacokinetics, Pharmacodynamics and Efficacy
of AMG 232 Combined with Trametinib and Dabrafenib or Trametinib in Adult Subjects with Metastatic Cutaneous Melanoma
A Phase 1b / 2 Open - Label
Study to Evaluate Safety, Clinical Activity,
Pharmacokinetics and Pharmacodynamics
of Avelumab (MSB0010718C) in Combination with Other Cancer Immunotherapies in Patients with Advanced Malignancies
The prototype
of such bis - macrocycles, plerixafor, was used in a recent
study as a starting point for structural modification, in order to identify compounds endowed with a similar antiviral activity and improved
pharmacokinetic properties [94].
An Open - Label Multicenter Phase 1
Study to Evaluate the Safety,
Pharmacokinetics and Pharmacodynamics
of H3B - 6527 in Subjects with Advanced Hepatocellular Carcinoma or Intrahepatic Cholangiocarcinoma
An Open - Label, Multicenter Phase I
Study to Characterize the Safety, Tolerability, Preliminary Anti-Tumor Activity,
Pharmacokinetics and Maximum Tolerated Dose
of BAY 1251152 in Patients with Advanced Hematological Malignancies
A Multi-arm, Phase Ib, Open - Label, Multicentre
Study to Assess the Safety, Tolerability,
Pharmacokinetics and Preliminary Anti-tumour Activity
of AZD9291 in Combination with Ascending Doses
of Novel Therapeutics in Patients with EGFRm + Advanced NSCLC who have progressed following therapy with an EGFR TKI (TATTON)
Safety, tolerability, and
pharmacokinetic interactions
of the antituberculous agent TMC207 (bedaquiline) with efavirenz in healthy volunteers: AIDS Clinical Trials Group
Study A5267.
In a
study published in a recent edition
of Nano Letters, the Laboratory's Mike Malfatti, Heather Palko, Ed Kuhn and Ken Turteltaub report on accelerator mass spectrometry measurements used to investigate the relationship between administered dose,
pharmacokinetics (PK), and long - term...
The Intestine Chip therefore may be useful as a research tool for applications where normal intestinal function is crucial, including
studies of metabolism, nutrition, infection, and drug
pharmacokinetics, as well as personalized medicine.
The randomized, double - blind, placebo - controlled
study will evaluate the safety and tolerability
of multiple doses
of NPT088, as well as
pharmacokinetics, immunogenicity and pharmacodynamic characteristics, as measured by Aβ and tau PET imaging.
In a
study published in a recent edition
of Nano Letters, the Laboratory's Mike Malfatti, Heather Palko, Ed Kuhn and Ken Turteltaub report on accelerator mass spectrometry measurements used to investigate the relationship between administered dose,
pharmacokinetics (PK), and long - term biodistribution
of carbon 14 - labeled silica nanopartocles in vivo.
Phase I safety,
pharmacokinetics, and pharmacogenetics
study of the antituberculosis drug PA - 824 with concomitant lopinavir - ritonavir, efavirenz, or rifampin.
individual would be 1.47 mg / kg, but our
pharmacokinetic study indicated that in macaques, a dose
of 5 mg / kg is to achieve MIC levels in blood for over 80 %
of the treatment duration
of 12 hours.
Studies determining Absorption, Distribution, Metabolism and Excretion (ADME) patterns in laboratory animals and humans are an integral part
of the Drug Metabolism and
Pharmacokinetics (DMPK) services provided by QPS.
With the exception
of IK14 (0.1 — 0.26 μg / mL), the values obtained (0.98 — 1.87 μg / mL) were above or consistent with expected trough values derived from our previous
pharmacokinetic study [38].
The Phase 1b / 2a
study of ISIS - SMNRx is a multiple - dose, dose - escalation
study designed to assess the safety, tolerability and
pharmacokinetic profile
of the drug in children with SMA between the ages
of 2 - 15 who are medically stable.
The purpose
of this
study is to evaluate the safety,
pharmacokinetics, pharmacodynamics and clinical activity
of AG - 120 in advanced hematologic malignancies that harbor an IDH1 mutation.
179/5: 00 Genome - wide association
study of olanzapine
pharmacokinetics.
This
study established the MTD
of the cyclophosphamide - huKS - IL2 combination (mainly limited by IL - 2 side effects), the
pharmacokinetics of huKS - IL2 and its systemic immunologic and immunogenic effects in patients with solid tumors (BMC Cancer.
Since the proposed model may be used in further
studies and the results
of the
study could be interpreted by people who are not familiar with the peculiarity
of nicotine / cotinine
pharmacokinetics in mice, we attempted to estimate the level
of nicotine (and e-liquid vapor) exposure used in the discussed
study.
Due to the sex - related disparities in
pharmacokinetics and bioavailability results reported by different authors (Soldin, Chung, & Mattison, 2011; Soldin & Mattison, 2009), the choice
of a single genus was chosen to avoid a high dispersion in the data, and the availability
of healthy young adult female volunteers for the
study.
This paper,
Pharmacokinetics of acute tryptophan depletion using a gelatin - based protein in male and female Wistar rats summarizes what we find in a number
of studies that use gelatin for the purpose
of lowering serotonin levels, in order to
study the relationship between serotonin and behavior:
New research published in November 2015:
Study of GABA in Healthy Volunteers:
Pharmacokinetics and Pharmacodynamics shows potential benefits for diabetes:
Pharmacokinetics and endometrial tissue levels
of progesterone after administration by intramuscular and vaginal routes: a comparative
study.
Pharmacokinetics of famciclovir and penciclovir in tears following oral administration
of famciclovir to cats: a pilot
study.
In 2016 Colorado State University (CSU) completed a
study on safety, toxicity, and
pharmacokinetics of cannabidiol in healthy dogs.
Despite the wide use
of chlorambucil in cats, the
pharmacokinetic parameters (i.e. how the body absorbs, metabolizes and eliminates the drug) have not been previously
studied in cats.
This
study aims to describe the
pharmacokinetic profile
of vinblastine in cats and to identify which characteristics or traits that can vary from one cat to another (e.g., age, kidney function, liver function) influence how vinblastine is distributed and eliminated in cats.
The purpose
of this
study was to describe the
pharmacokinetics and pharmacodynamics
of an extended - release buprenorphine (ERB) formulation in healthy adult dogs.
Taking your example
of pharmacokinetics / dynamics, Bayesian methods are useful because we have a «good» understanding
of the system under
study; i.e: the number
of compartments (roughly, their effective volumes, the rates
of transfer between them etc..
In her
study, «
Pharmacokinetics of Etonogestrel Contraceptive Implant in Obese Women,» Dr. Gilliam and colleagues at the University of Chicago studied the pharmacokinetics of the Implanon contraceptive implant
Pharmacokinetics of Etonogestrel Contraceptive Implant in Obese Women,» Dr. Gilliam and colleagues at the University
of Chicago
studied the
pharmacokinetics of the Implanon contraceptive implant
pharmacokinetics of the Implanon contraceptive implant in obese women.