Sentences with word «pharmacokinetics»
Since it is plausible that the unfavorable pharmacokinetic profile of 182a is due to a rapid oxidative metabolism, a series of derivatives functionalized with electron deficient moieties on the terminal aromatic ring were synthesized.
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I have working experience in pharmacokinetic modeling, metabolite kinetics, in vitro drug metabolism and mass spectrometry.
«To our knowledge, this is the first pharmacokinetic study of lithium salicylate and lithium lactate in laboratory animals,» Smith said.
Despite the disadvantages in terms of pharmacokinetic properties, these peptides have been instrumental in defining a basic pharmacophore model for designing smaller molecules.
Approval may be accelerated by knowledge of previous preclinical and clinical data on pharmacokinetics, side effects and regimens [5, 87, 88].
Extralabel use in food animals necessitates an extralabel withdrawal interval to be assigned by the attending veterinarian on the basis of information on the species, dose, route and frequency of treatment in conjunction with available scientific pharmacokinetic data.
«Based on the variability of pharmacokinetic parameters and drug clearance, the two Vancomycin nomograms developed to predict therapeutic Vancomycin concentrations in healthy adults did not accurately estimate dosage regimens in older children regardless of weight or age, and therefore should not be used to aid empiric dosing,» said Dr. Jessica Gillon.
Corley also leads a $ 1.6 - million project that will be the first attempt to construct a physiologically based pharmacokinetic (PBPK) model for application to multiple species, including mouse and human.
The prototype of such bis - macrocycles, plerixafor, was used in a recent study as a starting point for structural modification, in order to identify compounds endowed with a similar antiviral activity and improved pharmacokinetic properties [94].
«ISRIB shows good pharmacokinetic properties [how a drug is absorbed, distributed and eliminated], readily crosses the blood - brain barrier, and exhibits no overt toxicity in mice, which makes it very useful for studies in mice,» Walter said.
Patient demographics, actual bodyweight, vancomycin dose, and vancomycin trough data was obtained from pharmacokinetic tracking forms filled out prospectively by ICU clinical pharmacists.
«Population pharmacokinetic analysis of blood and joint synovial fluid concentrations of robenacoxib from healthy dogs and dogs with osteoarthritis.»
The randomized, double - blind, placebo - controlled study will evaluate the safety and tolerability of multiple doses of NPT088, as well as pharmacokinetics, immunogenicity and pharmacodynamic characteristics, as measured by Aβ and tau PET imaging.
However, the double positive charge at the physiological pH precludes a complete absorption, as showed by preliminary pharmacokinetic studies.
Antagonist antibody against human TIGIT that demonstrates a classical human IgG pharmacokinetics profile.
«Population pharmacokinetic analysis of blood and joint fluid concentrations of robenacoxib from healthy dogs and dogs with osteoarthritis.»
About a year ago, she joined FDA, where she reviews pharmacokinetics for neuropharmacologic drugs.
It has been known that salt content in a diet can influence pharmacokinetics of the antiepileptic drug potassium bromide.
The physicochemical and mouse pharmacokinetic properties of BAZ2 - ICR were assessed.
Methylxanthine, green tea, theophylline, and then dark chocolate like theobromine and you get, therefore, three very different pharmacokinetic profiles, meaning for those people who don't know the term, the rate at which those peak in your blood plasma.
«Although it is well known that RYGB affects how the body handles alcohol, findings from earlier studies on the effects of sleeve gastrectomy on alcohol pharmacokinetics are contradictory.»
The single pharmacokinetic study published on non-concentrate naloxone showed that only 4 % of naloxone is absorbed when administered nasally.
Importantly, due to their limited pharmacokinetic interactions with other agents, DCV+SOF was able to work effectively across a broad range of concomitant combination antiretroviral therapy (cART) regimens without compromising HIV virologic control (98 % of patients were on cART).
In this study, NPT088 was safe and well - tolerated at multiple dose levels, with a suitable pharmacokinetic profile.
These results suggest a huge variety of genes showing sex dimorphism in hepatic genes, which might influence drug pharmacokinetics in a sex - specific way.
Comparison of the single dose pharmacokinetics, pharmacodynamics, and safety of two novel oral formulations of dimethandrolone undecanoate (DMAU): a potential oral, male contraceptive.
Dr. Lukas» research interests are the neurobiological basis of drug and alcohol addiction, including pharmacokinetics, polydrug abuse, sex differences, complementary / alternative medicine, and medication development.
Monitors and analyzes drug therapy regimens with health care providers (based upon pharmacokinetics, patient disease state status, and medication history) to provide the most effective, least toxic, and most economical drug treatment plan.
We have synthesized and evaluated more than 600 novel AAPs and have identified AAPs with high potencies and favorable intravenous and oral pharmacokinetics.»
(6) Based on what is known about the behavior of the antibody and the available pharmacokinetic data, Prothena CEO Gene Kinney has stated (albeit without presenting modeling to support the assertion) that «we would expect to fully saturate that pathological load [of aggregated AS] in patients with Parkinson's disease.»
Morris Animal Foundation: Martin J Fettman, DVM, Colorado State University is initiating a two year study «Dietary Effects on Phenobarbital Pharmacokinetics in Canine Epilepsy.»
Most of the information available comes from case reports, case series, and pharmacokinetic investigations [62].
Stavchansky S, Combs A, Sagraves R, Delgado M, Joshi A. Pharmacokinetics of caffeine in breast milk and plasma after single oral administration of caffeine to lactating mothers.
Transplacental, maternal and neonatal pharmacokinetics.
In particular, the team looked at pharmacokinetics, which influences the concentration of a drug reaching its target, and pharmacodynamics, which determines the drug response.
CT - P13 has previously demonstrated pharmacokinetic (PK) equivalence to INX in the PLANETAS trial, a randomised double - blind, parallel group study of 250 patients with AS, and was recently approved by the European Medicines Agency.
According to Dr Won Park, Inha University Hospital, Korea, and lead investigator of the PLANETAS study, «the challenge for biosimilars is to demonstrate similarity in therapeutic effectiveness, safety and immunogenicity to their reference product, not just biochemical and pharmacokinetic equivalence.»
They must still confirm the precise pharmacokinetics, or how the body processes the therapy after it is administered.
The investigators are currently designing a study to correlate pharmacokinetics, the time course of drug metabolism, with genotype.
«Perhaps giving a person the right dose, at just the right time, of a drug with just the right pharmacokinetic properties so its effect will wear off at the right time would work a lot better than bombarding the brain with benzodiazepines, such as Valium, that knock out the entire brain.»
Weikop, P.; Egestad, B.; Kehr, J. Application of triple - probe microdialysis for fast pharmacokinetic / pharmacodynamic evaluation of dopamimetic activity of drug candidates in the rat brain.
[A summary: scaling up is difficult, testing pharmacokinetics, toxicity and efficacy is difficult, and so is satisfying the FDA.]
Gut Microbiota - Regulated Pharmacokinetics of Berberine and Active Metabolites in Beagle Dogs After Oral Administration — Ru Feng — Frontiers in Pharmacology
Again, this was only a basic safety and pharmacokinetics trial, and was conducted in healthy young people without PD.
The primary outcomes of both trials are safety (adverse events) tolerability, and a wide array of pharmacokinetic outcomes (which are curiously designated as safety issues).