High profits may be justified if novel
products offer significant benefits to patients (thus producing indirect economic value through the patients» restored health) or if they represent significant
pharmacologic advances over their predecessors — offering new mechanisms of actions and emblematic of high - risk research.
Pharmacologic treatment with ivermectin, loperamide, vincristine, and other drugs that are substrates of P - glycoprotein, the MDR1 gene
product, may result in neurologic toxicosis in a high percentage of Collies.