Sentences with phrase «pharmacologic suppressors»

Moreover, large - scale screens in the C. elegans DMD model allowed identifying genetic and pharmacologic suppressors of dystrophin - dependent muscle degeneration; some of them positively impact mitochondrial functions or structure under stress conditions, or are involved in signaling pathways linked to mitochondria, and others are associated to proteostasis pathways such as autophagy, proteasome and Unfolded Protein Response (UPR).

Not exact matches

This prompted us to characterize in more detail shared mechanisms and pathways and to target them with genetic and pharmacologic means so as to identify some broadly efficient suppressors of muscle degeneration.