Sentences with phrase «pharmacological effect of»

Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans.

Animal studies done in the UK and South Africa found no pharmacological effects of rhino horn — or any other animal horns.

When not given psilocybin, the subjects received methylphenidate, more commonly known as Ritalin, which shares some of the pharmacological effects of its psychedelic counterpart.

In vivo pharmacological effects of JZP - 4, a novel anticonvulsant, in models for anticonvulsant, antimania and antidepressant activity.

[17] The other is the direct pharmacological effects of the essential oils.

The effects of 256 food constituents on pharmacological effects of interacting drugs and bioactivities of 149 food constituents were also finally predicted.

Lean and diet - induced obese mice were used to characterize single - dose in vivo pharmacological effects of IRAB - A; multiple - dose IRAB - A effects were tested in obese mice.

However, the main active compound in saffron is crocin, responsible for the color and most of the pharmacological effects of the herb.

One study reported that pharmacological effects of these drugs elevated the risk of these cardiac - based illnesses (17).

Not exact matches

To quote the researchers: «Thus, modification of this PIP2 regulatory domain by genetic, biochemical, or pharmacological mechanisms may have profound effects on sensitivity of primary afferent nerve fibers to chemical and thermal stimuli under normal or pathological conditions.»

The new definition reads: «A substance produces a psychoactive effect in a person if, by stimulating or depressing the person's central nervous system, it affects the person's mental functioning or emotional state; as measured by the production of a pharmacological response on the central nervous system or which produces a response in in - vitro tests qualitatively identical to substances controlled under the Misuse of Drugs Act 1971, and references to a substance's psychoactive effects are to be read accordingly.»

There are now over 9000 reports of TCM medicines; however, only about 500 of these are commonly used by TCM practitioners, and only 80 or so (see the box for some examples) have amply demonstrated pharmacological effects — from the perspective of?

These pharmacological effects typically mirror those originally described for the herbs by the Chinese physicians of 2000 years ago, although modern studies have in some cases revealed new pharmacological benefits that were not previously recognized by TCM doctors.

New avenues of research could include the effects of reducing environmental stress, as well as whether pharmacological agents might be able to reverse the genetic alternations in vulnerable children before the disorder develops.

The identification of these opiate - induced changes offers the best hope for developing more effective pharmacological targets and therapies to prevent or reverse the effect of opiate exposure and addiction.

«One could imagine, quite rapidly, a pharmacological approach that could basically wipe out the effects between morning and afternoon,» said University of Lille - France professor Bart Staels, one of the study's authors.

But even more damning from a pharmacological perspective, the team found the same effect at all doses of either herbicide or GM maize.

Gozzi, A. * Schwarz, A., Reese, T., Bertani, S., Crestan, V., Bifone, A. Region - specific effects of nicotine on brain activity: A pharmacological MRI study in the drug - näve rat (2006) Neuropsychopharmacology, 31 (8), pp. 1690 - 1703

Specific targeting of neurotoxic side effects and pharmacological profile of the novel cancer stem cell drug salinomycin in mice.

Paterson, N. E. Behavioural and pharmacological mechanisms of bupropion's anti-smoking effects: recent preclinical and clinical insights.

, Lepore S, Vicentini E, Merlo - Pich E, Bifone A Differential effect of Orexin - 1 and CRF - 1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor yohimbine (2013) Neuropsychopharmacology, 38 (11), pp. 2120 - 2130 8.

The goal was to deepen the knowledge about the pharmacological and cytotoxic effects of the drug Temodex in vitro in different human brain cancer cell lines.

Freitas et al (2011) performed a systematic search of all studies using non-invasive stimulation in Alzheimer's disease (AD) and reviewed all 29 identified articles; 24 focused on measures of motor cortical reactivity and (local) plasticity and functional connectivity, with 8 of these studies assessing also effects of pharmacological agents, and 5 studies focused on the enhancement of cognitive function in AD.

Very importantly, DDI types predicted by DeepDDI are generated in the form of human - readable sentences as outputs, which describe changes in pharmacological effects and / or the risk of ADEs as a result of the interaction between two drugs in pair.

«Deficient neuron - microglia signaling results in impaired functional brain connectivity and social behavior» Y. Zhan, R.C. Paolicelli, F. Sforazzini, L. Weinhard, G. Bolasco, F. Pagani, A. L. Vyssotski, A. Bifone, A. Gozzi, D. Ragozzino, C.T. Gross Nature Neuroscience 17 (3), 400-4006 (2014) «USPIO - loaded Red Blood Cells as a biomimetic MR contrast agent: a relaxometric study» A. Boni, D. Ceratti, A. Antonelli, C. Sfara, M. Magnani, E. Manuali, S. Salamida, A. Gozzi, and A. Bifone Contrast Media and Molecular Imaging 9, 229 - 236 (2014) «Distributed BOLD and CBV - weighted resting - state networks in the mouse brain» F. Sforazzini, A.J. Schwarz, A. Galbusera, A. Bifone, and A. Gozzi NeuroImage 87, 403 - 415 (2014) «Antimicrobial peptides design by evolutionary multiobject optimization» G. Maccari, M. Di Luca, R. Nifosì, F. Caldarelli, G. Signore, C. Boccardi, and A. Bifone PloS Computational Biology 9 (9): e1003212 (2013) «Differential effect of orexin - 1 and crf - 1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor yohimbine» A. Gozzi, S: Lepore, E: Merlo Pich, and A. Bifone Neuropsychopharmacology 38 (11): 2120 - 2130 (2013) «Water dispersal and functionalization of hydrophobic iron oxide nanoparticles with lipid - modified poly (amidoamine) dendrimers» A. Boni, L. Albertazzi, C. Innocenti, M. Gemmi, and A. Bifone.

Our results reinforce the potential pharmacological interest of kahweol, as suggested by its anti-angiogenic and anti-inflammatory effects.

Since invasion is dependent on extracellular matrix remodeling capabilities, this inhibitory effect strongly suggested that the two key extracellular membrane remodeling enzymes expressed by endothelial cells, namely, MMP - 2 and uPA could be other main key targets of the pharmacological action of kahweol on endothelial cells.

Furthermore, the inhibitory effects of kahweol on COX - 2 and MCP - 1 reinforce the idea of kahweol being a multi-targeted natural compound with high pharmacological potential.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Under normal conditions, deletion of the transporter does not lead to any noticeable phenotype, suggesting that pharmacological or biological blockade of the transporter for therapeutic purposes is not likely to elicit significant off - target effects in normal tissues.

Finally, pharmacological PPARα activation had a minimal effect on expression of cold - induced genes in murine WAT.

Genotypic differences established here can be used to monitor basal ganglia circuitry dysfunction in HD models with the potential to evaluate pathway - selective effects of pharmacological treatments.

In our pharmacological class, we discovered aging due to oxidative damage, number of cell divisons, waste accumulation theory, teleomer lengths, effects due to circadian clock etc..

Several experimental and clinical studies of salidroside have provided evidence of its multiple pharmacological activities including anti-inflammation, anti-oxidation, anti-stress, anti-cancer, and enhancing immune effects.

Unique pharmacological profiles of substances in the SARM class mean they have a different range of effects and androgenic binding ratios.

These effects of Cy -3-g are largely abolished by pharmacological and genetic inhibition of AMPK.

In one representative country, chronic pain takes up one - fifth of the entire health care expenditure, whereas in another it is three times as costly as all types of cancer together.59 One strategy which remains unexplored and could yield important insights is to combine a ketogenic diet with a known hypoalgesic pharmacological agent (e.g. amitriptyline) and note additive or synergistic effects, as have been noted for seizure control but only for some drugs.60

After reviewing the clinical and experimental evidence relating to the possible mechanisms of action of acupuncture on polycystic ovarian syndrome, it is clear that acupuncture modulates the nervous system, the endocrine system and the neuroendocrine system; and that acupuncture has been demonstrated to be a suitable alternative or complement to pharmacological induction of ovulation, without adverse side effects.»

To be successful, these dietary strategies need to ensure a high response without the side effects of pharmacological treatments.

A 2003 study published in the Journal of Pharmacological Sciences examined the anxiety - abolishing effects of both Ginkgo biloba and Asian ginseng, finding that while both were effective in reducing acute stress, supplementing with Asian ginseng was the most effective in significantly lowering chronic stress.

Because of the negative side - effects of pharmacological interventions, adults with dis - ordered sleep are increasingly seeking non-pharmacological sleep interventions such as natural supplements (e.g., melatonin, valerian, and tryptophan), meditation, and sleep hygiene programs (Henry et al., 2013).

In the following sections, we first provide an overview of treatment effects of non-pharmacological and common pharmacological treatments compared with inactive interventions.

Sixteen systematic reviews provided data on 17 comparisons with inactive interventions (placebo, sham interventions or waiting list).30 — 32 35 — 37 39 — 43 45 — 50 figure 2 provides an overview of treatment effects of non-pharmacological and common pharmacological treatments for MDD when compared with inactive interventions using standardised mean differences.

Reviews with a favourable conclusion about psychological therapies (vs pharmacological interventions) are at high risk for a spin in conclusions (OR = 8.31 (1.41 to 49.05)-RRB-, whereas favourable conclusions about effects of pharmacological interventions showed no spin in our sample (OR = 1.00 (0.16 to 6.14).

Also the conclusion of equal effects of psychological therapies and pharmacological interventions does not face a risk of spin (OR = 0.12 (0.01 to 1.08).

An attractive feature of this well designed clinical trial was the testing of «allegiance effects» by conducting the study at 2 sites, each associated primarily with publishing outcome studies of either psychosocial or pharmacological treatments.

What are the effects of psychological and pharmacological interventions for depression in coronary artery disease (CAD) patients with comorbid depression?

Ideally, treating pharmacologists would be blind to concurrent psychosocial treatments, and the effects of CFF - CBT or other novel treatments could be distinguished from the impact of specific pharmacological agents or dosing strategies.

Abstract: Clinical trials to evaluate the therapeutic effect of pharmacological interventions are mostly conducted as double - blind comparative studies.

Clinical trials to evaluate the therapeutic effect of pharmacological interventions are mostly conducted as double - blind comparative studies.