Sentences with phrase «pharmacological inhibition of»

We show that pharmacological inhibition of CD38 results in higher intracellular NAD + levels and that treatment of cell cultures with apigenin decreases global acetylation as well as the acetylation of p53 and RelA - p65.

Mice harboring a T106M mutation in p38alpha are resistant to pharmacological inhibition of LPS - induced TNF production and collagen antibody - induced arthritis, indicating that p38beta activity is not required for acute or chronic inflammatory responses.

These results demonstrate that ABL kinase activity is required for osteolytic metastasis in breast cancer and suggest that pharmacological inhibition of the ABL kinases may be an effective treatment for bone metastasis.

First based on our completed genetic study we will test if pharmacological inhibition of an identified protein via direct eye injection can promote long distance optic nerve regeneration or whether, based on strong preliminary data, manipulation of another novel gene can induce such regeneration.

Cells were exposed to 2.0 and 3.0 Gy of radiation with or without prior pharmacological inhibition of ERK1 / 2, AKT as well as JNK pathways.

Pharmacological Inhibition of Host Heme Oxygenase - 1 Suppresses Mycobacterium tuberculosis Infection In Vivo by a Mechanism Dependent on T Lymphocytes.

Pharmacological inhibition of nutrient uptake decreased CML stem cell activity in vivo.

Not exact matches

Pharmacological and genetic inhibition of autophagy increase SMN levels, while induction of autophagy decreases SMN.

Such inhibition of fertility suggests that testes are exquisitely sensitive to disruption of retinoid signaling and that these receptors could be targets for pharmacological intervention of fertility (male contraception).

Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4 / 6 inhibition.

Through first pharmacological and later genetic means, the group demonstrate that inhibition of ERK5 causes an enhancement of vomocytosis.

These effects of Cy -3-g are largely abolished by pharmacological and genetic inhibition of AMPK.