Unique
pharmacological profiles of substances in the SARM class mean they have a different range of effects and androgenic binding ratios.
They note that a related compound with better
pharmacological profiles than CLP257 was as effective in reducing pain in rats as an existing pain treatment called pregabalin, but it lacked the undesirable motor side effects that are often seen with that drug.
This development could find broad applications in pharmaceutical and agricultural industries, enabling medicinal chemists to tailor synthetic molecules with halogen substituents in order to improve
their pharmacological profiles.
Jordi Mestres, coordinator of the IMIM and UPF research group on Systems Pharmacology at the Biomedical Informatics Program (GRIB) states «With this study we have contributed to complementing the detection of these quite unstable fragments, with information on the mechanism of action of the drug, based on three aspects: similarity to other medicines, prediction of
their pharmacological profile, and interference with specific biological pathways.
The role of academic scientists in this process has largely been to explain the genetic / cellular basis of diseases for identifying useful targets and provide new chemical and computational methods to improve
the pharmacological profile of potential drugs.
Specific targeting of neurotoxic side effects and
pharmacological profile of the novel cancer stem cell drug salinomycin in mice.
The novel triple reuptake inhibitor JZAD - IV - 22 exhibits an antidepressant
pharmacological profile without locomotor stimulant or sensitization properties.
Schütz K, Carle R, Schieber A. Taraxacum — a review on its phytochemical and
pharmacological profile.
Antipsychotic: CBD has
a pharmacological profile similar to certain antipsychotic drugs.
Not exact matches
As a consequence, bardoxolone has a complicated
pharmacological and toxicological
profile with significant clinical safety problems.
The
pharmacological activity of each echinacea species appears to reflect the slight variation in the amount of active ingredients and their chemical
profiles.