Pharmacological targeting of guanosine monophosphate synthase suppresses melanoma cell invasion and tumorigenicity.
In fact, genetic and
pharmacological targeting of the IRE - 1 / XBP - 1 pathway of the endoplasmic reticulum stress response, which is critical for antibody production, results in decreased numbers and reduced functions of MDSCs.
Not exact matches
This study reveals that the circadian clock is able to reprogram itself depending on a diet's nutritional content — which could lead to the identification
of novel
pharmacological targets for controlled diets.
In a study published in the April issue
of the Journal
of Neuroscience, Saint Louis University scientists led by professor
of pharmacological and physiological sciences Daniela Salvemini, Ph.D., discovered that drugs
targeting the A3 adenosine receptor can «turn off» pain signals in the spinal cord to provide relief from chronic pain.
«Our research shows that
targeting cannabinoid receptors in the periphery with
pharmacological inhibitors that do not reach the brain holds promise as a safe therapeutic approach for the treatment
of overeating and diet - induced obesity,» said Nicholas V. DiPatrizio, an assistant professor
of biomedical sciences in the School
of Medicine, who led the research project.
New
pharmacological approaches to
target these changes will provide much needed and more effective treatments to reduce the power
of drug - related associative memories that drive opiate addiction.
«The fact that the vitamin B12 - taurine - bone pathway affects only bone formation and appears to play the same role in mice and human beings raises the prospect that
targeting this pathway through
pharmacological means could be a novel approach toward an anabolic treatment
of osteoporosis.»
The identification
of these opiate - induced changes offers the best hope for developing more effective
pharmacological targets and therapies to prevent or reverse the effect
of opiate exposure and addiction.
«New drug
targets for Ras - dependent cancers have long been sought,» said Arvin Dar, PhD, Assistant Professor
of Oncological Sciences and
Pharmacological Sciences at The Tisch Cancer Institute at the Icahn School
of Medicine at Mount Sinai and lead researcher on the study.
Previous studies had supported the possibility
of targeting oncogenic forms
of Ras via KSR, but no
pharmacological approaches had been reported until now.
They're looking at the same types
of pharmacological targets that maybe only used to be pursued at a drug company in the past,» says Philip Mayer, president
of the American Association
of Pharmaceutical Scientists in Arlington, Virginia.
Now, we can use copper - catalyzed conditions which are applicable to versatile fluoroalkenes to replace fluorine atoms with boron, which opens up a huge range
of potential
target molecules and should boost the use
of fluoroalkenes in
pharmacological studies.»
Noting that this anticipatory phase is often at the root
of many people's sleeping problems, de Lecea suggested that the newly identified circuit could be a
target for
pharmacological intervention to help people ease into sleep.
He adds that the project «is just the beginning for the establishment
of a new class
of pharmacological entity, «sticky» biologics, characterized by localized,
targeted activity.
The role
of academic scientists in this process has largely been to explain the genetic / cellular basis
of diseases for identifying useful
targets and provide new chemical and computational methods to improve the
pharmacological profile
of potential drugs.
Such inhibition
of fertility suggests that testes are exquisitely sensitive to disruption
of retinoid signaling and that these receptors could be
targets for
pharmacological intervention
of fertility (male contraception).
«The gender gap in mental health has been inadequately
targeted and often only within the standard medical arsenal
of pharmacological treatment,» Rojiani said.
Specific
targeting of neurotoxic side effects and
pharmacological profile
of the novel cancer stem cell drug salinomycin in mice.
These are critical observations that will allow the field
of autophagy to move beyond the utilization
of lysosomal inhibitors for the
pharmacological treatment
of cancer by
targeting autophagy.
American Federation for Aging Research Fellow at the Albert Einstein College
of Medicine in New York; USA From: Salt Lake City, USA Prize Category: Translational Medicine Essay: A Novel
Target for
Pharmacological Intervention in an Untreatable Human Disease
The Institute's phenotyping platforms are adapted for the study
of mutant mice and genetic reference populations but can also be used for preclinical studies including the validation
of therapeutic
targets as well as
pharmacological and toxicological studies in the mouse.
He aims to develop sets
of targets for selective
pharmacological manipulation
of circuitries involved in acquisition
of fear and extinction learning.
Thus, Eph receptor -
targeting peptides represent valuable
pharmacological tools to study the functional importance
of specific Eph receptors in tumors and the nervous system.
Since invasion is dependent on extracellular matrix remodeling capabilities, this inhibitory effect strongly suggested that the two key extracellular membrane remodeling enzymes expressed by endothelial cells, namely, MMP - 2 and uPA could be other main key
targets of the
pharmacological action
of kahweol on endothelial cells.
Any
of these key steps can be a potential
pharmacological target to inhibit angiogenesis and, hence, to treat angiogenesis - dependent diseases [9].
Susan Amara, USA - «Regulation
of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation
of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses
of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology
of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy
of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis
of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms
of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect
of beta adrenergic stimulation; cardiovascular function
of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation
of Vascular Tone, Adipose Tissue Regulation
of Vascular Function in Obesity, Diabetes and Hypertension,
Pharmacological Characterization
of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions
of Biologically Active Components
of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology
of G protein - coupled receptors, in particular opioid receptors, regulation
of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design
of highly selective inhibitors (so call chemical probes)
targeting protein kinases as well as protein interaction inhibitors
of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution
of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation
of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function
of GABA - A receptors; mode
of action
of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation
of expression and function
of the ATP - binding cassette (ABC) transporters
Under normal conditions, deletion
of the transporter does not lead to any noticeable phenotype, suggesting that
pharmacological or biological blockade
of the transporter for therapeutic purposes is not likely to elicit significant off -
target effects in normal tissues.
Current knowledge suggests that the majority
of biologically active compounds interact with multiple molecular
targets exhibiting pleiotropic
pharmacological actions.
Despite more than half a century
of intensive research, however, insulin - degrading enzyme has remained «an especially elusive
pharmacological target,» biochemist Malcolm Leissring
of the Scripps Research Institute and neurobiologist Dennis Selkoe
of Harvard Medical School wrote in a commentary that accompanies the Nature article.
Genetic variation influencing blood pressure has the potential to identify new
pharmacological targets for the treatment
of hypertension.
Furthermore, as novel
pharmacological targets, the vanilloid receptors have potential for the development
of many future disease treatments.
According to the National Institute
of Mental Health,
pharmacological treatments are often prescribed based on specific
target symptoms shown by the individual patient.