Sentences with phrase «pharmacological targets»
Pharmacological targeting of guanosine monophosphate synthase suppresses melanoma cell invasion and tumorigenicity.
roswellpark.org
This study reveals that the circadian clock is able to reprogram itself depending on a diet's nutritional content — which could lead to the identification of novel pharmacological targets for controlled diets.
Furthermore, as novel pharmacological targets, the vanilloid receptors have potential for the development of many future disease treatments.
The framework characterizes a drug's absorption, distribution and elimination properties, yielding information on pharmacological targets, physiological pathways and, ultimately, disease systems in patients, resulting in predictions of treatment effectiveness.
The identification of these opiate - induced changes offers the best hope for developing more effective pharmacological targets and therapies to prevent or reverse the effect of opiate exposure and addiction.
«They also underscore the emerging ties between cancer and HIV treatment through shared pharmacological targets.
Despite more than half a century of intensive research, however, insulin - degrading enzyme has remained «an especially elusive pharmacological target,» biochemist Malcolm Leissring of the Scripps Research Institute and neurobiologist Dennis Selkoe of Harvard Medical School wrote in a commentary that accompanies the Nature article.
Thus, the LPA - LPA2 axis is an attractive pharmacological target for novel strategies to control immune responses.
In fact, genetic and pharmacological targeting of the IRE - 1 / XBP - 1 pathway of the endoplasmic reticulum stress response, which is critical for antibody production, results in decreased numbers and reduced functions of MDSCs.
They're looking at the same types of pharmacological targets that maybe only used to be pursued at a drug company in the past,» says Philip Mayer, president of the American Association of Pharmaceutical Scientists in Arlington, Virginia.
Evidence supporting the CSC hypothesis and the potential of CSCs as a pharmacological target continues to accumulate.