Sentences with phrase «phase i trials for»

«Many of the current Phase I trials for spinal cord injury are run in the acute phase, which is right after injury.

«Together with The National Institute for Medical Research Tanzania, we are in the process of preparing phase I trials for a vaccine to prevent parasite binding in the placenta and malaria during pregnancy,» he explains.

Through CRI's Clinical Accelerator program, two new checkpoint inhibitor drugs, MEDI4736 (anti-PD-L1) and tremelimumab (anti-CTLA-4), are being tested in a phase I trial for patients with six different cancer types, including colorectal cancer, cervical cancer, head and neck cancer, kidney cancer, lung cancer, and ovarian cancer.

Merck's anti-PD-1 drug pembrolizumab (MK - 3475) is currently being investigated in a large a phase I trial for patients with metastatic melanoma and lung cancer.

Numerous Phase I trials for pediatric patients currently are open.

Not exact matches

Page and Wang are readying their drug for a three - month, FDA phase - 2 trial that's set to start next month.

«You look at a lot of ideas, rejecting most of them, flirting with a few, and then — hopefully — settling in for a trial phase with the most attractive and well - rounded option,» he writes in his book.

On Thursday, Whirlscape announced that the Minuum has left the beta phase, and is currently available to download on the Google Play store (as a free trial as well, for a limited time).

In November, the company announced that the results of a Phase III trial of solanezumab «were not what we had hoped for.»

And while the first phase of the trial was at times grueling for members of the jury - several breaking into tears as they listened to descriptions of the chaos near the Marathon finish line - the second phase could be even more so.

The company's lead product candidate, dilanubicel (NLA101), is currently being evaluated in two ongoing Phase 2 clinical trials in adult and pediatric patients with hematologic malignancies undergoing an allogeneic transplant and adult patients receiving high dose chemotherapy for Acute Myeloid Leukemia.

Dr. Chawla designed and led the ATHOS 3 Phase 3 trial for La Jolla Pharmaceutical's FDA - approved drug for shock, Giapreza ™.

And now, Lundbeck and partner Otsuka's experimental treatment for improving cognition in Alzheimer's patients has failed two more phase 3 trials, likely ending any remaining hopes for the drug.

«The positive efficacy results observed in the pivotal phase 3 clinical trials indicate that sarecycline can be an effective treatment option for patients with moderate to severe acne,» said Allergan R&D chief David Nicholson in a statement.

March 30, 2017 — Aura Biosciences Announces Initiation of Phase 1b Clinical Trial and Receipt of FDA Fast Track Designation for AU - 011 for the Treatment of Primary Ocular Melanoma

Cambridge, MA — March 30, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy cancer cells using viral nanoparticle conjugates, announced today that it has enrolled and dosed the first patient in its Phase 1b clinical trial of light - activated AU - 011, an investigational, first - in - class targeted therapy in development for the treatment of ocular melanoma, a rare and life - threatening disease.

For the second time in 5 months, Juno Therapeutics has put a clinical hold on a Phase II trial of JCAR015 in adult patients with relapsed or refractory B - cell acute lymphoblastic leukemia due to patient deaths.

Juno Therapeutics is seeking to change the protocol for the Phase II ROCKET clinical trial of its acute lymphoblastic leukemia candidate JCAR015, which the FDA has placed on clinical hold following the deaths of three patients, two of them last week.

However, following devastating news that the Phase III RESOLVE trial of its RSV vaccine failed to deliver the desired results, Novavax, Inc. (NASDAQ: NVAX) shareholders are looking for any...

Following disappointing Phase 3 results for the RSV vaccine in older adults, Novavax, Inc. (NASDAQ: NVAX) reported mixed results for a Phase 2 trial of the vaccine on older adults who were reimmunized.

With shares down sharply, the reaction to phase III trial results for the lupus drug has been «knee - jerk» and probably not fully reflective of the outlook for the...

Motif has successfully concluded a second phase III clinical trial on its lead drug, iclaprim and is preparing for regulatory...

This meeting will set the parameters for a pivotal phase 3 trial.

ALKS 3831 is a treatment for schizophrenia that avoids the side effects of weight gain and metabolic problems that the incumbent drug has, and a phase 3 trial for it should read out in the fall of 2018.

Most biotechs would have shuttered a clinical program that showed absolutely no efficacy whatsoever in a late - stage trial, but Novavax has instead doubled down on RSV by going forth with its phase 3 trial of the RSV F vaccine for infants via maternal immunization, and begun planning for another trial in older adults that's reportedly on track to kick off in 2018.

While the SC said that the Bt talong proponents neither went beyond the field - testing phase nor distributed the product commercially, MASIPAG is firm that the proponents will push for another round of Bt talong field trials and commercialization in the future.

Once the promotion phase is over, meat will be taken off the menu at the start of the week for a two - month trial period, after which it is expected that Meat Free Monday will be at UCLU to stay.

After trial and error, I've found that for bread — which I did miss during my initial Paleo phase, my best best is anything made with Sourdough culture.

I was nervous at first that my stomach wouldn't like the reintroduction of fermented soy after doing some time away from it (FODMAPS elimination phase), but after lengthy (read: exhausting) food trials with galactans (beans, peas, soy, etc.), I've determined miso and tempeh aren't problematic for me personally *.

but that's still a good reason for bifurcating trials into a determination of guilt and a determination of the sentence, with a separate jury doing each phase.

Seventeen swimmers advanced to the Phase 3 Trials for the 12U team, while 33 qualified for Phase 3 Trials for the 13 - 15 team.

Michigan Attorney General Bill Schuette says his Flint water crisis investigation is shifting to the «the trial phase,» but before it gets there, he's ramped up the stakes by charging five state and local officials with manslaughter for their actions related to the Flint water crisis.

As federal corruption trials loom for several associates of Governor Andrew Cuomo, the administration is forging ahead with Buffalo Billion II, the second phase in an ambitious plan to revitalize Buffalo's beleaguered economy and help transform Upstate New York into a hub of technology innovation and jobs.

«The number of cases in which people try to introduce neurotechnological evidence in the trial or sentencing phase has gone up by leaps and bounds,» says Joshua Sanes, director of the Center for Brain Science at Harvard University.

«This phase III trial will be noteworthy for being the first prostate cancer trial to assess a biomarker, namely AR - V7 in circulating tumour cells, as a predictor of response at the same time as testing the efficacy of the drug,» Prof Taplin will conclude.

In the international Phase 2 clinical trial, two study arms enrolled 24 cirrhotic patients each, none who had previously been treated for HCV infection.

The objective was to identify the dose and dosing frequency required for the phase III trials.

A phase I clinical trial for a Zika vaccine which began in August 2016 in partnership with the Wistar Institute and Inovio / GeneOne Pharmaceuticals aims to discover the safety and effectiveness of a DNA vaccine for Zika.

«There are currently no therapies which successfully reverse the damage seen in the more than 12,000 individuals who suffer a spinal cord injury each year in the United States alone,» says Dr. Richard G. Fessler, professor of neurological surgery at Rush University Medical Center and principal investigator for the Phase 1 clinical trial involving AST - OPC1 (oligodendrocyte progenitor cells).

The phase 1 clinical trial is the first to test the functional replacement of the mutated gene responsible for SMA1.

What are the plans for a phase II trial?

The randomised, blinded phase of the trial found no difference between the statin and placebo groups for erectile dysfunction (1.86 % vs 2.14 % per year).

The phase III CONVERT trial enrolled 547 patients with limited - stage SCLC for concurrent chemo - radiotherapy who were randomised to once - daily or twice - daily radiotherapy.

For example, an MDM2 - targeting drug shrank deep - tissue fat cell tumors in just one out of 20 patients in a phase I safety trial, published in 2012.

The Phase I clinical trial of OMP - 54F28 (FZD8 - Fc) is an open - label dose escalation study in patients with advanced solid tumors for which there was no remaining standard curative therapy.

«The results of the phase III clinical trial show that a target fusion biopsy detects more clinically significant prostate cancer,» said Art Rastinehad, DO, principal investigator of the study and director of interventonal urologic oncology at North Shore - LIJ's Arthur Smith Institute for Urology, in New Hyde Park, NY.

«As for the so - called sublingual and epicutaneous immunotherapy, which is treatment under the tongue or on the skin, respectively, the first few trial phases have already achieved some success.

He identified 193 Phase III randomized trials — the gold standard in clinical research — for analysis.

But highly trained life scientists will still be needed for such tasks as late - stage development (ensuring smooth implementation of final phase (III and IV) clinical trials) as well as compliance with regulatory demands (so - called commissioning and validation specialists), according to Croonen.

At the moment there are no therapies for humans and animals, but many new variants of immunotherapy have entered trial phase.