Sentences with phrase «phase i trials with»

My translational research interests involve clinical trials evaluating targeted biologic agents, particularly early phase trials with targeted antibodies.

[27] Besides BMS - 936558 (Nivolumab), another humanized anti-PD1 antibody, MK - 3475 (Lambrolizumab), has shown activity and acceptable toxicity in a phase I trial with metastatic melanoma.

Early phase trials with anti-PD-L1 and anti-PD-1 antibodies have shown clinical activity in RCC and early biomarker assessment suggests PD - L1 tumor expression may influence response.

To expand the Vanderbilt - Ingram Cancer Center's portfolio of early phase trials with new drugs and combinations

Many of these products are reaching late - phase trials with the potential to receive final approval and marketing authorization from regulatory agencies such as the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA).

PHILADELPHIA - Many people believe that phase I trials with healthy volunteers are very risky and because they pose risks with no benefits, unethical.

Not exact matches

The drug, with the unwieldy name ceftolozane / tazobactam, has completed Phase 3 clinical trials and could prove particularly effective in dealing with pseudomonas — bacteria usually acquired in hospitals that cause serious interabdominal and urinary tract infections, ultimately resulting in death in some cases.

In a research and strategy update, Novo said it will initiate a phase 3 clinical trial program with once - weekly subcutaneous semaglutide in obesity in the first half of 2018.

Acceleron is also advancing its neuromuscular franchise with two distinct Myostatin + agents, ACE - 083 and ACE - 2494, and a pulmonary program with a Phase 2 trial of sotatercept planned in pulmonary arterial hypertension.

«You look at a lot of ideas, rejecting most of them, flirting with a few, and then — hopefully — settling in for a trial phase with the most attractive and well - rounded option,» he writes in his book.

This year that newsworthy moment, in my view, had nothing to do with the latest Phase III drug trial, pharma merger, or biotech discovery.

In a research and strategy update, Novo said it planned to start a final phase 3 clinical trial program with once - weekly subcutaneous semaglutide in obesity in the first half of 2018.

Reldesemtiv is the subject of three ongoing Phase 2 clinical trials enrolling patients with spinal muscular atrophy, chronic obstructive pulmonary disease and amyotrophic lateral sclerosis.

Omecamtiv mecarbil is the subject of GALACTIC - HF, an international Phase 3 clinical trial in patients with heart failure.

The Finnish drug maker on Sunday presented results from phase I trial of a prostate cancer treatment, saying according the data it «has been well tolerated, with no significant treatment - related adverse events.»

The company's lead product candidate, dilanubicel (NLA101), is currently being evaluated in two ongoing Phase 2 clinical trials in adult and pediatric patients with hematologic malignancies undergoing an allogeneic transplant and adult patients receiving high dose chemotherapy for Acute Myeloid Leukemia.

The drug, lefamulin, is in phase three trials, with some results coming later this year.

«The positive efficacy results observed in the pivotal phase 3 clinical trials indicate that sarecycline can be an effective treatment option for patients with moderate to severe acne,» said Allergan R&D chief David Nicholson in a statement.

The company's leading program, a differentiated PPAR gamma agonist (MIN - 102) that has multiple CNS indications, has successfully completed a phase 1 clinical trial and is ready to move into a phase 2/3 study with adult AMN patients.

Defense attorneys pointed to Tamerlan's relationship with his wife to demonstrate his ability to influence his younger brother Dzhokhar, as they began their case Monday in the sentencing phase of Dzhokhar's trial.

For the second time in 5 months, Juno Therapeutics has put a clinical hold on a Phase II trial of JCAR015 in adult patients with relapsed or refractory B - cell acute lymphoblastic leukemia due to patient deaths.

One of Juno's rivals, Kite Pharma, yesterday said it had completed its enrollment of 72 patients with diffuse large B - cell lymphoma in the Phase II portion of the ZUMA - 1 trial, designed to assess KTE - C19.

Juno is developing its immunotherapy product candidate, JCAR017, which is in a Phase I trial, studying patients with B - cell Non-Hodgkin Lymphoma [NHL].

Dr. Newman added that rival CAR T cell therapy developer Kite Pharma was still likelier to generate more revenue than Juno with KTE - C19, which last week completed patient enrollment in the Phase II portion of the ZUMA - 1 trial in patients with diffuse large B - cell lymphoma.

CB - 1158 is being tested in a Phase I clinical trial in patients with solid tumors.»

It's doing a Phase 2 trial right now which will hopefully demonstrate equivalent or better efficacy but with greatly reduced negative side effects.

With shares down sharply, the reaction to phase III trial results for the lupus drug has been «knee - jerk» and probably not fully reflective of the outlook for the...

Most biotechs would have shuttered a clinical program that showed absolutely no efficacy whatsoever in a late - stage trial, but Novavax has instead doubled down on RSV by going forth with its phase 3 trial of the RSV F vaccine for infants via maternal immunization, and begun planning for another trial in older adults that's reportedly on track to kick off in 2018.

In collaboration with Indiana University and the National Institute on Alcohol Abuse and Alcoholism (NIAAA), Intercept is supporting a blinded Phase 2 trial treating 60 patients with alcoholic hepatitis (NCT02039219 on clinicaltrials.gov).

This includes a stem cell research centre, a network of drug discovery institutes and a # 20 million global clinical development fund dedicated to supporting Phase I and II clinical trials; and a # 2 million collaboration between University of Cambridge and University College London that will use donated cells from people with Alzheimer's to test potential new treatments

After trial and error, I've found that for bread — which I did miss during my initial Paleo phase, my best best is anything made with Sourdough culture.

I was nervous at first that my stomach wouldn't like the reintroduction of fermented soy after doing some time away from it (FODMAPS elimination phase), but after lengthy (read: exhausting) food trials with galactans (beans, peas, soy, etc.), I've determined miso and tempeh aren't problematic for me personally *.

but that's still a good reason for bifurcating trials into a determination of guilt and a determination of the sentence, with a separate jury doing each phase.

Now that they've demonstrated the significance of insulin signaling in the human mammary gland, they are planning a phase I / II clinical trial with a drug used to control blood sugar in type 2 diabetes to determine whether it improves insulin action in the mammary gland, thus improving milk supply.

Michigan Attorney General Bill Schuette says his Flint water crisis investigation is shifting to the «the trial phase,» but before it gets there, he's ramped up the stakes by charging five state and local officials with manslaughter for their actions related to the Flint water crisis.

Televising the sentencing phase of some trials seems, initially, the most likely opening, with perhaps greater access over time.

As federal corruption trials loom for several associates of Governor Andrew Cuomo, the administration is forging ahead with Buffalo Billion II, the second phase in an ambitious plan to revitalize Buffalo's beleaguered economy and help transform Upstate New York into a hub of technology innovation and jobs.

In his 2018 State of the State address, Cuomo outlined five criminal justice reforms, one of which dealt with the discovery phase before a trial.

We look forward to the results from the phase III trial with interest.»

Galeterone will now be tested in a phase III trial in which patients with metastatic CRPC with the AR - V7 variant will be randomised to receive either galeterone or enzalutamide.

The now familiar swings appeared in high relief last fall, with news of the most recent, phase III trial in Thailand.

Already, Phase 1 clinical trials are being conducted with specific IDH1 / 2 mutations.

«We may be testing this drug in combination with others in the next phase of trials,» said Dr. Williamson.

This open label, multicentre, phase 1B trial investigated the safety and efficacy of omaveloxolone in combination with the checkpoint inhibitors ipilimumab or nivolumab.

Based on results of the current study described in a report online June 18 in the journal Cancer Cell, Johns Hopkins researchers say they are planning a phase I clinical trial to test the paclitaxel - fostamatinib combination therapy in patients with recurrent advanced ovarian cancer.

A phase I clinical trial for a Zika vaccine which began in August 2016 in partnership with the Wistar Institute and Inovio / GeneOne Pharmaceuticals aims to discover the safety and effectiveness of a DNA vaccine for Zika.

The first phase of the trial was conducted in 1998 - 2002 and included 10,180 patients aged 40 - 79 with hypertension and at least three other cardiovascular risk factors from the UK, Ireland and Scandinavia.

Ophthalmologists at 10 sites nationwide tested the ring in a phase 2 clinical trial on patients with glaucoma or ocular hypertension.

A one - time intravenous infusion of the high dose of gene therapy extended the survival of patients with spinal muscular atrophy type 1 (SMA1) in a Phase 1 clinical trial, according to a study published in the New England Journal of Medicine.

In parallel, the Unit has just completed a second Phase I Clinical Trial with a drug of the same family named dovitinib.