Sentences with phrase «phase ib»

Early data from a small phase Ib / II study [23] of ipilimumab combined with T - VEC, which demonstrated that the combination offers much higher complete and overall response rates than have been seen with either agent alone, appear to confirm that there are beneficial synergies between these two therapeutic modalities.

Similarly, a combination phase Ib / II trial of PV - 10 and pembrolizumab [27] has been initiated in patients with stage IV melanoma.

A phase Ib study of pembrolizumab (MK - 3475) in patients with advanced triple - negative breast cancer.

An updated analysis of phase Ib safety and efficacy is planned.

Treatment with the anti — PD - 1 antibody pembrolizumab yielded good long - term survival outcomes in a phase Ib trial of patients with advanced melanoma.

The phase II part of a phase Ib / II study (ClinicalTrials.gov identifier: NCT02263508; MASTERKEY - 265)[24] assessing the safety and efficacy of T - VEC in combination with the PD - 1 — blocking antibody pembrolizumab in previously untreated, unresected stage IIIB / IV melanoma is evaluating confirmed ORR by irRECIST at week 24.

A Phase Ib / II Trial of Interleukin - 2 in Combination with Pembrolizumab for Patients with Unresectable or Metastatic Melanoma

There are two parts to this study: - Phase Ib: To determine the safety and side effects of increasing doses of IL - 2 in combination with pembrolizumab - Phase II: Once the maximum tolerated dose of IL - 2 is determined, additional patients will be treated to determine if it is effective against the cancer.

Within monts, PRX002 became the subject of two randomized, double - blind, placebo - controlled clinical trials: a three - month single - dose trial (Phase Ia) and a six - month multiple - dose ascending trial (Phase Ib).

A phase Ib clinical trial in age deescalating population will be performed to assess safety and immunogenicity.

Prothena announced the dosing of the first Phase Ia subject on April 8, 2014; they appear to have been successful in recruiting subjects and to have quickly derived favorable safety signals, as they announced the dosing of the first PD volunteer in the Phase Ib trial on July 31, 2014, «based upon safety and tolerability observed to date in the ongoing study in healthy volunteers.»

«Promising clinical activity and tolerability of the combination of encorafenib and binimetinib has been seen in patients with BRAF V600 — mutated melanoma in a phase Ib / II and a phase II study,» wrote study authors led by Reinhard Dummer, MD, of the University Hospital Zurich in Switzerland.

One secondary outcome will be immunogenicity, meaning monitoring subjects for any emergence of antibodies against the infused therapeutic antibodies themselves; additionally, «Multiple clinical and exploratory biomarkers will be assessed» in the Phase Ib trial.

The clinical trial is open labelled for the phase Ia arm conducted in Tübingen, Germany and double blinded for the phase Ib conducted at the Institut de Recherche Clinique du Bénin, Benin.

As there was a positive safety evaluation, a phase Ib study arm could start in Burkina Faso in December 2016.

A Multi-arm, Phase Ib, Open - Label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of AZD9291 in Combination with Ascending Doses of Novel Therapeutics in Patients with EGFRm + Advanced NSCLC who have progressed following therapy with an EGFR TKI (TATTON)

A Phase Ib, Open - Label Study of the Safety and Tolerability of Atezolizumab in Combination with Radium - 223 Dichloride in Patients with Castrate - Resistant Prostate Cancer who have Progressed Following Treatment with an Androgen Pathway Inhibitor

These statistically significant and clinically meaningful improvements in overall response and survival rates resulted from a phase Ib / II clinical study performed at the HonorHealth Research Institute, a partnership of HonorHealth and TGen.

Immunotherapy with a live bacterium combined with chemotherapy demonstrated more than 90 % disease control and 59 % response rate in patients with malignant pleural mesothelioma (MPM), according to the results of a phase Ib trial presented today at the European Lung Cancer Conference (ELCC) 2016 in Geneva, Switzerland.1

Dr. Glen Weiss, M.D., M.B.A., is the first author of the study abstract: Phase Ib / II Study of Pembrolizumab plus Chemotherapy in Advanced Cancer: Results of lung cancer patients receiving (at least) 1 prior line of therapy.

Not exact matches

im not sure if these are the same concern in fructose malabsorption, but for the sake of using a low fodmaps diet to manage ibs, beans are a no - go... at least in the elimination phase.

A Phase III Randomized Trial of Adjuvant Chemotherapy with or without Bevacizumab for Patients with Completely Resected Stage IB (> or = 4 cm)- IIIA Non-Small Cell Lung Cancer (NSCLC)

The Center for Cancer Targeted Therapies (C2T2) integrates a phase I - Ib / early clinical trials program, a precision cancer medicine infrastructure with expertise on tumor tissue - based state - of - the - art molecular methods, and a core resource with novel non-invasive functional imaging methods.

The efficacy of the elimination phase of the low - FODMAP diet for overall gastrointestinal symptom relief in adult patients with IBS has been seen in randomized, controlled trials; a blinded, randomized, rechallenge study; and observational studies that have been reviewed in detail elsewhere

I hope you can answer this question for me — I have read on several websites that tempeh is low fodmap, but I just read the following in Patsy Catsos's book «IBS — Free At Last» second edition, page 116: «Soy products such as soy milk, tempeh, miso and soy protein isolate......... do contain carbohydrates from the soybean, so they are not allowed during the Elimination Phase of the diet.»

BTW I'm newly diagnosed IBS and have just decided to go onto the elimination phase using FODMAP diet.

For review of the elimination phase of the diet, IBS Free by Patsy Catsos is a great book and for recipes I have plenty on this blog but also in my low FODMAP downloadable cookbook link here: http://www.katescarlata.com/fodmap.htm

In the CDSA stool test, you will find that a marker called lactoferrin is only markedly elevated prior to and during the active phases of IBD, but not with IBS.

In the IBS patients, bowel symptoms significantly reduced during the FODMAP diet and increased during the typical diet phase.

The researchers conclude, «Peppermint oil may be used as a therapeutic agent during the symptomatic phase of IBS» (Kline et al., 2001).

All perfectly aligned with the CCSS expectations and the IB PYP Phases 3 and 4.

Role: Select a Role Director Head Teacher Principal Vice Director Vice Principal Head of Primary Head of Secondary Deputy Head of School Deputy Head of Primary Deputy Head of Secondary Head of Early Years Head of Prep School Director of Studies Academic Registrar Grade Level Coordinator Head of Department Head of Section Head of Subject Head of Year IB Coordinator Phase Coordinator Principal Inspector Second in Department Senior Inspector Teacher

The district has taken significant steps to expand the advanced and higher learning opportunities for all of its students (over 6,600), including reducing tracking for many courses All fourth - and fifth - grade students now benefit from the English Language Arts enrichment program and the district is in the second year of phasing in the rigorous, inquiry - based curriculum in its new International Baccalaureate (IB) Middle Years Program to prepare its students for college preparatory courses at the high school.

Its lead product candidate includes plecanatide a phase 3 guanylate cyclase C, or GC - C, receptor agonist, designed to treat GI disorders, primarily chronic idiopathic constipation, or CIC, and constipation - predominant irritable bowel syndrome, or IBS - C.

Tags for this Online Resume: AMICUS, Phlebotomy, Medical, Research, Cancer, clinical trials, regulatory, phase iii, phase ii, pharmaceutical, IRB, eCRF, Rave, ICF, Clinical Protocol, IB, Apheresis, Hematology, Leukemia Trials, GCP, Human Subject Protection, Medicine, HIPPA, Responsible Conduct of Research

Alterra IB, a 412 - unit property developed by Roseland, was the second rental phase of Overlook Ridge and construction was completed in 2008.