Sentences with phrase «phase cyclins»

Zoledronic acid augments the radiosensitivity of cancer cells through perturbing S - and M - phase cyclins and p21CIP1expression.

Not exact matches

There are as many as 14, but the scientists found that cyclin D adds just a single phosphate at one, and only one, of the 14 locations during the early G1 phase of cell cycle progression, essentially make 14 different versions of the Rb tumor suppressor.

A randoMized phAse II trIal of fulvestraNt wiTh or without Ribociclib After progression on AntI-estrogeN therapy plus cyclin - dependent kinase 4/6 inhibition in patients with unresectable or metastatic hormone receptor positive, HER2 negative breast cancer (MAINTAIN Trial)

Specifically, it inhibits cyclin - dependent kinase 4 (CDK4) and closely related CDK6; two factors that are essential to drive cells into DNA replication phase.

Viral Cyclins Mediate Separate Phases of Infection by Integrating Functions of Distinct Mammalian Cyclins.

Cyclin D1 - levels varying throughout cell cycle, hence its expression in G1 phase increases in the cell that respond to enter a new cycle after receiving growth factor stimulation [8].

Lin chart illustrates the correlation between Cyclin D1 IOD in Grade III with percentage of apoptotic phase.

These finding were exactly in accordance with Gillet et al., 1996 [24], who stated that, Cyclin D1 staining did not appear to correlate with an increased S - phase fraction as judged by flow cytometry.

Activated E2F leading to transcription of several target genes including cyclin E in late G1 phase which form active complex with CDK2 drives progression from G1 to S phase [7].

No significant correlation was observed between Cyclin D1 staining and S - phase % obtained by flow cytometry as illustrated in Table 5.

This contradictory behavior explained that Cyclin D1 acts as a negative regulative protein under some conditions rather than a positive regulator in the cell cycle, i.e. the modest increase in Cyclin D1 expression could hasten the G1 phase while the overexpression may lead to block the progression through the S - phase [28, 29].

In the correlation between the Cyclin D1 IOD and the different phases of the cell cycle it was noticed that, there was no any statistically association between Cyclin D1 - IOD and G1 phase % or S phase % in the all of individual groups.

Over again Cyclin D1 expression elevated during G2 phase which enables the cell to commit to continue the proliferation [10].

For confirming our study results, the correlation between Cyclin D1 - staining scores and the percentage of S - phase obtained by flow cytometry which showed no significant correlation between Cyclin D1 protein and increased S - phase %.

While during S phase the cell automatically suppresses Cyclin D1 formation because it has the ability to inhibit DNA synthesis which may block the cycle progression and lead to the cell - arrest in this position [9].

Senderowicz AM, Headlee D, Stinson SF, et al: Phase I trial of continuous infusion flavopiridol, a novel cyclin - dependent kinase inhibitor, in patients with refractory neoplasms.

Cyclins form complexes with cyclin - dependent kinases (CDKs), unique to each cell - cycle phase, and activate specific genes to drive cells through their cycles.