Sentences with phrase «phase trial testing»

Not exact matches

CB - 1158 is being tested in a Phase I clinical trial in patients with solid tumors.»

Completing ed enrollment of its Phase 3 Resolve trial, which is testing its RSV F Vaccine use in adults age 60 and older.

This includes a stem cell research centre, a network of drug discovery institutes and a # 20 million global clinical development fund dedicated to supporting Phase I and II clinical trials; and a # 2 million collaboration between University of Cambridge and University College London that will use donated cells from people with Alzheimer's to test potential new treatments

It tells the story of «the guinea pigs»» the people most likely to be research subjects in Phase I trials, which test the safety of a drug under development by giving it to healthy subjects and examining any side effects they experience.

While the SC said that the Bt talong proponents neither went beyond the field - testing phase nor distributed the product commercially, MASIPAG is firm that the proponents will push for another round of Bt talong field trials and commercialization in the future.

I acquired a total of 14 different all in one style newborn cloth diapers to test and trial during what would undoubtingly be a short lived newborn phase.

«This phase III trial will be noteworthy for being the first prostate cancer trial to assess a biomarker, namely AR - V7 in circulating tumour cells, as a predictor of response at the same time as testing the efficacy of the drug,» Prof Taplin will conclude.

Galeterone will now be tested in a phase III trial in which patients with metastatic CRPC with the AR - V7 variant will be randomised to receive either galeterone or enzalutamide.

«We may be testing this drug in combination with others in the next phase of trials,» said Dr. Williamson.

Based on results of the current study described in a report online June 18 in the journal Cancer Cell, Johns Hopkins researchers say they are planning a phase I clinical trial to test the paclitaxel - fostamatinib combination therapy in patients with recurrent advanced ovarian cancer.

The drug was developed by Lawrence - based CritiTech, and the drug - testing and phase I clinical trial were conducted by KU Cancer Center researchers, led by Stephen Williamson, M.D., medical director of Cancer Clinical Trials.

The phase 1 clinical trial is the first to test the functional replacement of the mutated gene responsible for SMA1.

ACT is now performing early - phase clinical trials testing the safety of implanting retinal cells derived from human ES cells into the eye to treat certain types of blindness.

Ophthalmologists at 10 sites nationwide tested the ring in a phase 2 clinical trial on patients with glaucoma or ocular hypertension.

The phase I trial is designed foremost to test whether the approach is safe.

All potential members go through an 18 - month trial phase to test the viability of their activity, during which time they can claim unemployment benefits from the French government to support themselves as they become established entrepreneurs.

The company plans in October to conduct a separate test specifically to study the seasonal flu vaccine's effectiveness among 480 elderly participants (a demographic often encouraged to get seasonal flu shots), and Phase III efficacy trials across a larger set of demographics are scheduled to begin early next year.

Luznik says that the researchers» next step will be to test the short course therapy in a phase III randomized clinical trial that would directly compare results in patients who receive the cyclophosphamide treatment with those who receive either a separate, experimental approach to prevent GVHD or the more traditional six - month immunosuppressive therapy.

Last month, Biopure launched a revamped clinical development program, emphasizing testing in Europe, with three phase II clinical trials planned for 2008 to study the impact of its product on heart attack patients, chemotherapy patients with anemia and the terminally ill.

In March, researchers, in collaboration with the pharmaceutical company Ultragenyx, completed the first part of a Phase III clinical trial in adults with XLH — the final test of a drug before federal approval.

In phase I trials, researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.

«Most pain medications that have been tested in the past decade have failed in phase II human trials despite performing well in animal models,» notes Clifford Woolf, MD, PhD, director of Boston Children's F.M. Kirby Neurobiology Center and a co-senior investigator on the study with Michael Costigan, PhD.

But the researchers caution that it will take several more years to get the compound into phase II clinical trials to test its potential as an effective and safe antidepressant for people.

The study was a randomized phase II trial testing whether the addition of local treatment, in the form of consolidative radiation therapy, to the standard treatment of systemic therapy improved progression - free survival for patients with limited metastatic NSCLC.

J147 has completed the FDA - required toxicology testing in animals, and funds are being sought to initiate phase 1 clinical trials in humans.

In a phase 1b clinical trial with 21 patients, researchers tested the safety and efficacy of combining the immunotherapy drug pembrolizumab with an oncolytic virus called T - VEC.

While patients in the Phase 1 trial tolerated the drug well it needs to be tested for longer time periods to prove its safety — particularly since this treatment would need repeated administration.

«To test the importance of such structural alteration as a genetic marker, a phase two clinical trial is ongoing at Kagoshima University and other institutions,» adds Ogawa.

Drs. Kelly and Knudsen are testing their hypothesis in a phase II clinical trial (ABICABAZI NCT02218606), currently recruiting patients.

Sangamo biochemist Philip Gregory notes that this Phase 1 clinical trial is the first human test of an entirely new class of drug that could turn any gene on or off, depending on the disease.

Since CGP3466B has already been tested in phase II clinical trials to (unsuccessfully) treat Parkinson's disease and ALS, it is known to be safe for humans, but the researchers caution that many more years of studies are needed to definitively show whether it is effective for preventing cocaine damage, first in mice, then in humans.

The results of the trial — a combined phase 1 and 2 study — strongly support testing of the drug in a larger group of patients in both phase 2 and 3 trials, the authors say.

He and colleagues are collaborating with the Sanford Burnham Prebys Medical Discovery Institute to design new assays to discover the next generation of CRF receptor - 1 antagonists for testing in early phase human safety trials.

Yong, a neuroscientist, initially had the idea to test the acne medicine in an animal model since minocycline has many anti-inflammatory properties that he thought could be useful in treating MS. Soon after obtaining successful research results, in studies also supported by the MS Society of Canada and MSSRF, Yong teamed up with Metz who led the transition into a pilot clinical trial, then a Phase 2, and finally the definitive Phase 3 trial.

Indeed, the authors note the speed with which a second FDA - approved drug believed to have promise in subduing HIV, Deferiprone, has moved directly from tests in culture to a phase I human trial conducted in South Africa, thanks to previously published results now reinforced by additional research in culture described in the current paper.

«We are delighted to receive this CIRM grant that will drive our translational research from the laboratory to the clinic,» Slamon said, «and allow us to test our targeted drug in a phase I clinical trial.»

Some CCR2 inhibitors are being tested in phase 1 and 2 clinical trials for treating rheumatoid arthritis.

Just a few weeks ago, WHO said that using any of the experimental drugs or vaccines in the pipeline simply wasn't in the cards, because none of them have been through a phase I clinical study, the type of trial in which medical products are tested on healthy volunteers to study their toxicity.

Worse, many promising drug candidates fail in phase II clinical trials when their efficacy is put to the test.

Angélica Nogueira - Rodrigues, MD, PhD, of the Brazilian National Cancer Insitute, and her colleagues designed a phase 2 clinical trial to test the potential of the EFGR inhibitor erlotinib combined with chemoradiation therapy in 36 women with cervical cancer.

This compound has been recently designated for phase III clinical trials to test its efficacy for treating epilepsy and providing relief of neuropathic pain.

«The first phase of clinical trials are tests of human safety, so this is a promising start,» Alvey said.

The Phase 2 trial — which will test an existing anti-inflammatory's ability to block inflammation and pyroptosis in HIV - infected people — promises to validate a variety of expected advantages to this therapy.

And because their signal blocker is an antibody already in phase I clinical trials for cancer treatment, they're hoping to make a quick jump into human testing for cardiovascular disease.

And results still won't be required for early trials, known as phase I, which test a product's safety.

A $ 2.4 million, 12 - week phase 1 trial testing the safety and tolerability of the steroid allopregnanolone for treatment of mild cognitive impairment and Alzheimer's, led by Roberta Brinton and Lon Schneider of the University of Southern California in Los Angeles.

We even plan to open a phase 1 clinical trial next year testing a different CTV expressing mda - 7 / IL - 24 in patients with recurrent brain cancer.»

At Merck Frosst Canada, I have been an integral part of the discovery of a new molecule, the testing of its mechanism of action, the validation of its safety and efficacy in Phase IIb and III clinical trials, the market approval of the resulting product, and the subsequent management of patients and their disease.

Spark Therapeutics in Philadelphia, Pennsylvania, which is testing the Bennett group's therapy in a phase III clinical trial needed to seek regulatory approval, also maintains that the NEJM results may not be relevant to their product.

By 2007, the drug had been tested on cells and in a phase I clinical safety trial in healthy volunteers.