Sentences with word «phenotype»

Phenotype refers to the observable traits or characteristics of an individual organism, which are determined by both its genetic makeup (genotype) and the environment it is in. It includes physical traits like height, hair color, and eye color, as well as behavioral traits and abilities. Full definition
Sea Lion Island shelter a small, localized population of elephant seals, that we are studying in great detail by marking almost all breeding individuals every season, by spending a large amount of time in the field doing behavioural observations, and by using a mixture of different techniques to gather accurate measurements of different aspects of individual phenotype of males and females.
Harmonising ontological descriptions of phenotype in mouse and human and improving links between mouse model data and human data, using diabetes and obesity as examples, will increase the relevance of data that is generated in mouse studies for clinical studies.
Critical issues include: (i) heterogeneity in stem cell populations (ii) regulation of cell fate choices; (iii) declining tissue performance with age and exposure to environmental injuries; (iv) the use of iPS and Embryonic Stem (ES) cells, and reprogramming methods for phenotyping disease states and potential use of these stem cells in the clinic.
General transcription factor TFIIH plays central roles in gene transcription and DNA repair ISB researchers and collaborators map the architecture of the TFIIH complex using powerful crosslinking - mass spectrometry (CXMS) technology and integrative modeling Structural maps provide critical insights into how mutations in TFIIH subunits lead to disease phenotypes By Jie Luo and Mark Gillespie The expression, or transcription, of genes controls the identity and function of a cell.
Resveratrol ameliorates aging - related metabolic phenotypes by inhibiting cAMP phosphodiesterases.
Our efforts are mostly centered on DNA methylation, how it influences gametic production and integrity, and impacts on phenotypes at following generations.
Over several decades, thousands of sets of phenotype data from BXD mice have been collected into databases, ranging from coat color to lifespan.
Furthermore, postnatal inactivation of htt in brain and testes also produces a progressive behavioral phenotype in mice along with neurodegeneration and reduced survival.
Characterization of putative stem cell phenotype in human limbal epithelia.
Abnormal Physiological and Molecular Mutant Phenotypes Link Chloroplast Polynucleotide Phosphorylase to the Phosphorus Deprivation Response in Arabidopsis
This data is made even more impactful due to its rich annotations which allow it to be mapped to annotated human phenotype data (via HPO mappings, as shown in the DIAB ontology).
Like most age - related diseases, this is a complex phenotype with numerous risk factors, but there's clearly a substantial inherited component at play.
Some specific phenotypes for cycling women and / or menopausal women that - that will help with even some of those symptoms of the receptor site level, depending if we have a cycling or a menopausal issue.
Nicholas Tatonetti, PhD, Herbert Irving Comprehensive Cancer Center, will receive $ 370,824 over five years from the National Cancer Institute for «Advanced Development and Dissemination of EMERSE for Cancer Phenotyping from Medical Records.»
Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 X4 Titration of infectivity (TCID50 / ml): 10e6.6 SUBTYPE: F1 This isolate is part of an European Panel of HIV - 1 isolates form the Network of Excellence European Vaccines and Microbicides
To determine whether rapamycin slows aging, we assessed a large number of structural and functional aging phenotypes in multiple cell types, tissues, and organs systems in our aging mouse cohorts.
But by hierarchical clustering of observed alterations in endocytosis, the researchers identified two distinct cancer phenotype clusters, one marked by mutations in the oncogene KRAS in mesenchymal cells and the other by changes in epithelial cells.
The scale and scope of these data are enabling genotype - phenotype association studies to identify genetic determinants of pathogen virulence and drug / insecticide resistance, and phylogenetic studies to track the origin and spread of disease outbreaks.
This greater risk of psychopathology is also likely to extend to other phenotypes associated with the opioid and serotonin systems for which there is less available data, such as antisocial behavior and substance abuse.
Research initiatives in his laboratory include analysis of the interaction between host immune factors (e.g., macrophages) and muscle stem cell remodeling during HIV - associated muscle wasting, and the molecular phenotyping of aging and identification of biomarkers for anabolic response.
However, unfortunately the mechanisms of tumor cells have the ability to resist to immunotherapy and patients who relapse with acquired resistance to BRAF and MEK inhibitors often present with melanomas that display a much more aggressive and invasive phenotype [13, 14].
Using this approach, researchers can easily generate diseaserelevant isogenic models to determine the impact of correcting or introducing disease - relevant mutations on cellular phenotypes in a tissue - appropriate context.
To characterize activation of immune cells, measurement of intracellular signaling using phospho - specific antibodies combined with immune phenotyping using surface markers is ideal.
Some patients with HER2 - positive breast cancer may develop an immunosuppressive phenotype based on an increase in regulatory T cells following treatment, according to a new analysis.
«Senescence - associated secretory phenotypes reveal cell - nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.»
Other members of the ALDH superfamily have been associated with other clinical phenotypes including alcohol - induced flushing.
I agree with Christelyn that it's probably more a situation of «In social settings people of similar phenotypes often gravitate toward each other when other «unknowns» are present.»
Four research teams of I - Stem have joined forces in a collaborative project that has just achieved a first pilot therapy - oriented screen of compounds and RNA interference aiming at reversing the altered phenotypes observed in human embryonic stem cells carrying the mutant gene for myotonic dystrophy type 1.
«Our data suggest that early - stage HER2 - positive breast cancers treated with neoadjuvant combination docetaxel, carboplatin, and trastuzumab with or without pertuzumab demonstrate tumor immune microenvironment phenotype changes,» the authors concluded.
Since fatty acids can affect phenotype through a variety of mechanisms (gene expression, eiconsanoid production, membrane receptor function), it is important to include information about the type and level of fat used in a study in order to allow other researchers to compare data.
In genetics, canalization is the process by which the same phenotype emerges across different environments because it is difficult to break out of a «canal.»
Structural equation modelling (SEM) minimizes the problem of residual errors by modelling associations between latent traits rather than observed variables, and also allows examination of associations whilst allowing for the correlation between phenotypes.
In these analyses, six of 90 F1 progeny (∼ 7 %) showed a distinct phenotype compared to the haploid parental strain XL280 and the remaining 84 progeny showed no phenotypic differences from the wild - type (Figure 3A and Figure S3).
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