Sentences with phrase «phenotype association»

The scale and scope of these data are enabling genotype - phenotype association studies to identify genetic determinants of pathogen virulence and drug / insecticide resistance, and phylogenetic studies to track the origin and spread of disease outbreaks.

28.04 % of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal behavior (1360/4850)

Scientists have already used the resource to identify hundreds of thousands of gene - phenotypes associations, many of which are completely new.

Personalised Medicine initiatives will benefit greatly from this emerging data and biological resources which can be used to detect novel genotype - to - phenotype associations in diseases.

Gene - to - phenotype associations are made by a versioned statistical analysis with all data freely available.

From 2008 - 2010, he was supported by the CGGH to study phenotypic variation in the drug sensitivity of Plasmodium falciparum isolates collected Kilifi District, and to investigate genotype - phenotype associations using genome sequencing data generated on these isolates at the Wellcome Trust Sanger Institute.

They took 5,694 curated genotype - phenotype associations from the NHGRI GWAS catalog (comprising 4,724 unique SNPs associated with 470 different phenotypes), and performed a functional annotation of those variants using data from ENCODE and other sources.

Our current understanding of the genetic basis of melanin - phenotype associations allows for both convergent and parallel evolution, but this understanding is still limited.

Placed into a phylogenetic context, this will help clarify to what extent these associations result from convergent or parallel evolutionary processes and why melanin - phenotype associations are so common across the tree of life.

The general ecological scenarios whereby melanin - based coloration is under selection, protection from UV radiation, thermoregulation in cold environments or as a signal of social status, offer a good opportunity to study how melanin - phenotype associations evolve.

In this session, we will describe cutting - edge approaches to experimentally validate, in a high - throughput manner, candidate mechanisms underlying observed genotype - phenotype associations.

Genome - wide association studies (GWAS) have yielded thousands of reproducible genotype - phenotype associations.

Longitudinal across - phenotype associations were substantially weaker than cross-sectional associations or within - phenotype longitudinal associations.

Not exact matches

This dataset contains millions of genomic sequences from a diverse set of rice varieties that, when combined with phenotyping observations, gene expression, and other information, provides an important step in establishing gene - trait associations, building predictive models, and applying these models to breeding.

Genome - wide scans aim to uncover genes having direct main effects (i.e., genes that show associations with phenotypes regardless of participants» environments).

This functional association of SREs may indicate a future phenotype, providing improved understanding of the father's contribution to the life course of the child as well as the current state of paternal health.

Bioinformatic approaches to the analysis of genetic variability and complex genotype - phenotype relationships will moreover include gene sequence and database analyses, measures of association of haplotypes / genotypes with phenotype, clustering procedures, neuronal networks, fuzzy and other techniques in pattern recognition, similarity measures for discrete patterns (e.g., gene sequences, structures, functions), logistic regression methods, and a spectrum of other techniques.

Diagram indicating associations among genetic and environmental factors reduce and their interactions with intermediate phenotypes to yield distinct pathophenotypes.

These findings in murine muscle, coupled with a significant association between a SNP in exon 3 of the IL15RA gene and human endurance athletes, support our hypothesis whereby IL - 15Rα has a role in defining the phenotype of fast skeletal muscles.

To achieve this level of insight will require a network ‐ based analysis of the associations among the individual genes, proteins, metabolites, intermediate phenotypes, and environmental factors that conspire to yield the pathophenotype.

Although the current study demonstrates that loss of IL - 15Rα promotes this phenotype, future studies are needed to determine the roles of specific IL - 15Rα isoforms in muscle, as well as the associations of additional IL15RA polymorphisms in muscle phenotypes in humans.

RGC will provide these centers whole exome sequencing and genome - wide association (with phenotype, where applicable) data free - of - charge.

The challenge of genetic association studies — especially ones for complex phenotypes — is confirming statistical evidence of association with a functional assay.

In the last decade, genome - wide association studies (GWAS) enabled by cheap, high - throughput SNP genotyping have identified thousands of loci that influence disease susceptibility, quantitative traits, and other complex phenotypes.

This is the case at the level of loci (e.g. identifying causal variants underlying genome - wide associations), genes (e.g. understanding not only that mutations in gene X underlie a given phenotype, but also the how and why of it), and variants (e.g. variants of uncertain significance).

These tools allow researchers to explore associations among a variety of immune characterizations as well as with genomic and clinical phenotypes.

If a modifier is associated with a clinical phenotype, we need to confirm that association,» said Kaye.

Chris is a statistical geneticist with a broad range of interests from population genetics to association analysis of clinical phenotypes.

We have generated rich genomic datasets for the scientific community, including an expansive atlas of genetic associations with metabolites, whole - genome sequence and phenotype data for population cohorts in the UK10K project, as well as bioinformatic resources to facilitate the retrieval of information, including a metabolite network, a database of genotype - metabolite associations with our colleagues at the HelmHoltz institute, and a genome browser of UK10K association results.

Development of computational approaches to predict associations between phenotype and genotype (Forward and Reverse Genomics)

The lab's goal is to develop computational approaches to study phenotype - genotype associations using the power of comparative and evolutionary genomics, followed by experimental verifications.

Computational Biology and Evolutionary Genomics: Discovering phenotype - genotype associations

Emergent phenotypes: association between morphology and coloration in fish.

In quantitive genetics, development is often conceptualised as a «genotype - phenotype map», estimated by the statistical associations of genetic loci and measured phenotypes.

It's no secret that while genome - wide association studies (GWAS) have implicated thousands of genetic loci in human phenotypes, the variants uncovered collectively explain only a fraction of the observed variance between individuals.

Melanocortin - 1 receptor polymorphisms and risk of melanoma: is the association explained solely by pigmentation phenotype?

Addition of these types of congenital anomalies to the CZS phenotype will likely require epidemiologic studies to help exclude coincidental associations and determine a more complete phenotype for CZS.75

The NASP output can be used for genome - wide association studies (GWAS) to correlate the genotype and phenotype, and can also be used for phylogenomics, which allows for an understanding of the relatedness of microbial isolates across temporal and spatial scales.

In the current study using 3D MRI data in a larger sample (N = 5,388), multiple SNPs showed significant association with multiple facial phenotypes, even after an over-conservative Bonferroni correction.

We examined 152 SNPs in 71 candidate genes for association with diabetes status and related phenotypes in 2,134 Caucasians in a case - control study and an independent quantitative trait (QT) cohort in the United Kingdom.

Out of the 40 instances of such large CNVs that were not implicated previously for AN or neuropsychiatric phenotypes, two of them contained genes with previous neuropsychiatric associations, and only five of them had no associated reports in public CNV databases.

This dataset contains millions of genomic sequences from a diverse set of rice varieties that, when combined with phenotyping observations, gene expression, and other information, provides an important step in establishing gene - trait associations, building predictive models, and applying these models to breeding.

GWAS Central; summary level genotype - to - phenotype information from genetic association studies.

Objectives: To undertake a genome - wide association study (GWAS) to identify genetic predisposing factors for the different clinical phenotypes associated with nevirapine hypersensitivity.

Topics of interest include gene - environment interactions, genetic associations with asthma - associated phenotypes such as allergies and lung function, and the role of tissue - specific gene expression.

12:30 PM Defects of the maintenance methyltransferase DNMT1 lead to progressive neurological phenotypes in association with global hypomethylation.

43/2: 30 Association of copy number variations with decreased cognitive phenotypes and fitness in unselected populations.

We tested for associations between personality, morphology, and locomotor performance by comparing zebrafish (Danio rerio) collected from the wild and then selectively bred for either a proactive or reactive stress coping style («bold» or «shy» phenotypes).

Objective To test the association of a polygenic risk score for waist - to - hip ratio (WHR) adjusted for body mass index (BMI), a measure of abdominal adiposity, with type 2 diabetes and CHD through the potential intermediates of blood lipids, blood pressure, and glycemic phenotypes.

One way to employ the information in the association between the genotypes and the phenotype is to assess the combined genetic marker contribution to the trait independently of mutation discovery.