Sentences with phrase «phenotype through»

Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat

Deterministic analysis supported by simulations showed that a 19 % greater response could be achieved using EBV compared to phenotype through increases in accuracy alone.

These special cows, which some might think have been injected with steroids all their lives, have actually acquired this peculiar phenotype through many years of careful genetic selection.

However, sex differences in regulatory mechanisms of genes could be the key element in explaining sexual dimorphism, leading to variations in phenotype through gene - environment interactions (194).

Many species have altered range limits and phenotypes through 20th - century climate change, but responses are highly variable.

Variant phenotyping through functional studies will facilitate defining key somatic events in cancer.

However, only few studies showed or discussed the possibility of establishing irreversible phenotypes through cycling hypoxic exposure without genetic manipulation [41, 42].

Opportunities to refine phenotypes through an understanding of their genetic influences will be important to characterize genetic and environmental etiologies.

Not exact matches

«This recognition may be driven through familiarity with a shared father or through some form of phenotype matching.»

His current specific interest is the elucidation of novel mechanisms of drug resistance through the discovery / identification of novel gene function (s) and phenotypes using RNAi - mediated gene silencing or cDNA overexpression.

Looking to the future, Nakagawa adds, «Through our analysis, we were able to identify some liver cancers with biliary phenotype that are closer to liver cancer, and others that are similar to bile duct cancer.

«Through social media, we're amassing huge amounts of data on ourselves, behaviorally and over time, that is leaving behind a kind of digital phenotype,» Wolff adds.

More than just a means of tying a suspect to a crime scene, genetic information can reveal clues about a culprit's appearance through a process called DNA phenotyping.

Harvard Medical School in Boston, which received a $ 9 million award in January to act as «coordinating center,» will facilitate collaboration between researchers and will make patient data widely available through public repositories such as NIH's database of Genotypes and Phenotypes, explained Anastasia Wise, director of NHGRI's Division of Genomic Medicine, at a press conference today.

Since 2007, the GWAS policy has governed biomedical researchers» submission and access to human data through the NIH database for Genotypes and Phenotypes (dbGaP).

Fourth, disease network analysis ultimately provides a mechanistic basis for defining phenotypic differences among individuals with the same disease through consideration of unique genetic and environmental factors that govern intermediate phenotypes contributing to disease expression.

First author Mahul Chakraborty looks through several specimens of fruit flies to identify new phenotypes.

A total of 22 mouse mutant lines can be characterised through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human disease.

High - throughput multidimensional phenotyping: mapping gene - gene and gene - drug interactions through computational image analysis of cell and tissue microscopy, machine learning and mathematical modelling.

Through the use of immunological, molecular and cell biological techniques, my laboratory is defining the phenotype and function of different monocyte subsets that infiltrate the central nervous system following traumatic injury.

Both the knockout and normal phenotype data will be made available through the KOMP2 data coordination center so that researchers who acquire and study the knockout mice can compare various phenotypes.

Through single and multi-gene manipulations, we are learning new information about the genotype - phenotype linkage across multiple kingdoms of life.

The EUMODIC consortium developed and validated robust methodologies for the broad - based phenotyping of knockouts through a pipeline comprising 20 disease - oriented platforms.

The overall goal of this study is to improve knowledge of the mechanism of HPV carcinogenesis and discover potential biomarkers in the vaginal microbiome predictive or protective of persistent HPV infection through interrogation of vaginal microbiota in a well phenotyped, homogenous cohort of Asian women.

General Product Information Obesity - High Fat Diets for Diet - Induced Obesity Models Metabolic Syndrome - Diet - Induced Metabolic Syndrome in Rodent Models Diabetes - High Fructose / Sucrose Diets for inducing Hypertriglyceridemia and Insulin Resistance in Rodents Atherosclerosis - Diet - Induced Atherosclerosis / Hypercholesterolemia in Rodent Models Hypertension - Phenotypic Expression of Hypertension in Rodent Models through Dietary Manipulation NAFLD (Non-alcoholic Fatty Liver Disease) Cancer - Creating a Clean Background for Oncology Research Test Compounds / Kaolin Pellets Diet and Immunology Focus: Arsenic in Grain - Based Laboratory Animal Diets and Effects on the Rodent Toxicological Phenotype Focus: The Importance of a Proper Control Diet

The Human Phenotype Ontology project: linking molecular biology and disease through phenotPhenotype Ontology project: linking molecular biology and disease through phenotypephenotype data.

Through the efforts of many laboratories over the past 30 years, approximately 25 % of the genome has been subjected to saturation mutagenesis experiments which attempt to identify all the genes that can mutate to an easily detectable phenotype.

Through field studies, we show that fungal gall morphology, which is induced by midges (i.e., it is an extended phenotype) is under directional and diversifying selection by parasitoid enemies.

Following expiry of an optional grace period, phenotype data will ultimately be made publicly available through a phenotyping database

Mouse mutant lines can be tested through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human disease.

The nature of individual phenotypes and appropriate specialist care associated with novel mouse mutants is being determined through the IMPC initiative.

Through its partnership with the International Mouse Phenotyping Consortium (IMPC), PHENOMIN has generated 150 new mouse models for the French scientific community.

Test each mutant mouse line (4,000 mouse lines in the first 5 years, and ultimately up to 20,000) through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human diseases.Through this activity and employing data annotation tools, systematically aim to discover and ascribe biological function to each gene, driving new ideas and underpinning future research into biological systems.

In the recent case series, most infants with probable congenital ZIKV infection were noted to have craniofacial disproportion (95.8 %) and, to a lesser degree, biparietal depression (83.3 %), prominent occiput (75 %), and excess nuchal skin (47.9 %).38 Features supportive of the FBDS phenotype scattered through published reports include redundant scalp, 27,36,39,41 occipital prominence and / or overlapping sutures,14,20,22 - 24, 26,27,38 and typical craniofacial appearance with disproportion.13, 27,33,34,40 The FBDS phenotype is also prevalent in ZIKV - related media.47 Among infants with severe microcephaly, the pattern appears to be consistent, although the degree of cranial vault deformation varies.

I have spent many years studying 2q23.1 deletion and duplication syndrome through genotype - phenotype, neural progenitor stem cells, and RNA - seq studies.

Through the generation and focused phenotyping of prospective rat models, where gene targets have been identified through the systematic mouse phenotyping effort, we focus our complementary analyses to conditions where the larger size and higher cognitive function of the rat is advantageous for more complex and accurate physiological assesThrough the generation and focused phenotyping of prospective rat models, where gene targets have been identified through the systematic mouse phenotyping effort, we focus our complementary analyses to conditions where the larger size and higher cognitive function of the rat is advantageous for more complex and accurate physiological assesthrough the systematic mouse phenotyping effort, we focus our complementary analyses to conditions where the larger size and higher cognitive function of the rat is advantageous for more complex and accurate physiological assessments.

How are robust phenotypes shaped through evolution, while preserving room for plasticity for evolvability?

Objective: We carried out de novo recruitment of a population - based cohort (MANOLIS study) and describe the specific population, which displays interesting characteristics in terms of diet and health in old age, through deep phenotyping.

Through genome - wide profiling we find that 5 - 46 % of the variation in different iPS cell phenotypes, including differentiation capacity and cellular morphology, arises from differences between individuals.

Furthermore, where mutations are enriched or lost in a gene after passaging the library through a selective process, the gene is likely to be involved in phenotypes linked to the process.

Senescent cells may promote tumour progression through the activation of a senescence - associated secretory phenotype (SASP), whether these cells are capable of initiating tumourigenesis in vivo is not known.

To address this challenge, the International Mouse Phenotyping Consortium is creating a genome - and phenome - wide catalog of gene function by characterizing new knockout - mouse strains across diverse biological systems through a broad set of standardized phenotyPhenotyping Consortium is creating a genome - and phenome - wide catalog of gene function by characterizing new knockout - mouse strains across diverse biological systems through a broad set of standardized phenotypingphenotyping tests.

To assist drug development through the identification of essential genes and pathways, we have measured competitive growth rates in mice of 2,578 barcoded Plasmodium berghei knockout mutants, representing > 50 % of the genome, and created a phenotype database.

Taking the microbiome into account may be important for accurate phenotype - genotype analysis due to the increasing awareness of the impact the microbes have on different body sites, through the products they produce, their ability to protect against invading organisms, their direct interaction with the cell structures and the extracellular milieu, provoking inflammatory or immune responses, and many other effects.

The database will allow users to view and download computed GTEx results and provide a controlled access system for de-identified individual - level genotype, expression, and clinical data through NCBI's database of Genotypes and Phenotypes, at http://www.ncbi.nlm.nih.gov/gap.

We applied our technology to several epigenetic regulators, recovering bi-allelic targeted clones with a high efficiency of 60 % and used Flp recombinase to restore expression in two null cell lines to demonstrate how our system confirms causality through mutant phenotype reversion.

Methods: Through ongoing collaboration, we had collected patients with strikingly - similar phenotype.

Importantly, there is a clear signature of the parents» sensitivity to high CO2 in the molecular phenotype of the offspring expressed by the differential regulation of genes controlling the circadian rhythm indicating adaptive potential through natural standing variation.

Our reasoning, admittedly speculative, is that (a) the cancer cellular phenotype is a wayward phenotype characterized by reduced intercellular cooperation, cooperation that is largely mediated through glycoproteins, proteoglycans, and glycosylated proteins; (b) cells evolve the cancer phenotype in part by disabling the enzymes which glycosylate proteins; (c) therefore (the speculative inference) dietary steps which downregulate glycosylation may inadvertently serve to entrench or promote the cancer phenotype.

Objective To test the association of a polygenic risk score for waist - to - hip ratio (WHR) adjusted for body mass index (BMI), a measure of abdominal adiposity, with type 2 diabetes and CHD through the potential intermediates of blood lipids, blood pressure, and glycemic phenotypes.