Sentences with phrase «phenotypes by»

«Our research shows that combination treatment with the two compounds can promote resilience against stress - mediated depression - like phenotypes by modulating systemic inflammatory responses and brain synaptic plasticity in a mouse model of depression,» says Jun Wang, PhD, Associate Professor of the Department of Neurology and first author on the paper.

Finally, transformation may provide a general approach to the analysis of complex heritable phenotypes by permitting the distinction between phenotypic changes without concomitant changes in DNA and functional genetic rearrangements.

They processed data relating to genetics, including DNA sequences, and to gene expression, as well as epigenetic features — chemical reactions that influence genome functioning and hence phenotype by activating and deactivating genes.

Hic - 5 promotes the hypertrophic scar myofibroblast phenotype by regulating the TGF - β1 autocrine loop.

They further show that, by regulating lipid metabolism, a cell is able to switch its immune phenotype by using transcriptional mechanisms and that the lipid environment has an important impact on immune cell function.

Following three months of treatment, all mice were analyzed for spatial memory by the two - day water maze, disinhibition phenotype by the elevated plus maze and hippocampal dependent memory by fear conditioning.

Control of the senescence - associated secretory phenotype by NF --LCB- kappa -RCB- B promotes senescence and enhances chemosensitivity.

The review will be based on short descriptions of the projects involving the mouse mutants that will be developed and phenotyped by the INFRAFRONTIER mouse clinics.

Call applications must be accompanied by a short description of the project involving the mouse mutant being developed and phenotyped by the INFRAFRONTIER mouse clinics

Application: Service requests for the second call of the INFRAFRONTIER - I3 mouse phenotyping service can be made via a dedicated application form available at https://www.infrafrontier.eu/resources-and-services/free-charge-transnational-access-services/application-pages Applications for the Transnational Access activity must be accompanied by a short description of the project involving the mouse mutant being phenotyped by the INFRAFRONTIER - I3 TA service.

Applications for the Transnational Access activity must be accompanied by a short description of the project involving the mouse mutant being phenotyped by the INFRAFRONTIER - I3 TA service.

The review will be based on short descriptions of the projects involving the mouse mutants that will be phenotyped by the TA service.

van Hecke O Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations.

Zika virus infection has spread to more than 45 countries in the Americas and 3 US territories, and, most recently, local transmission was confirmed in the continental United States in the state of Florida.11 Mosquito - borne transmission of ZIKV in other areas of the United States is possible based on the estimated range of its vectors (Aedes aegypti and Aedes albopictus).12 Recognition of the CZS phenotype by pediatric clinicians will help ensure appropriate and timely evaluation and follow - up of affected infants.

Recognition of this phenotype by pediatric clinicians will help ensure appropriate and timely evaluation and follow - up of affected infants.

Genes that have only been assigned for mouse production and phenotyping by the International Mouse Phenotyping Consortium (IMPC) and for which mice have not been produced, yet, it is possible to register interest on the IMPC webpage.

In order to avoid this issue, purified ingredient diet formulas which are open to the public (i.e. AIN - 76A) can be easily revised to intentionally alter the atherosclerosis phenotype by adding in fat calories (i.e. dairy butter, hydrogenated coconut oil) in place of purified carbohydrate calories only (i.e. sucrose, corn starch).

Other flow cytometry applications include: cellular phenotyping by multiparameter cytofluorimetric analysis, sorting of fluorescence protein - tagged cells, assessing apoptosis and cell cycle status, the identification / isolation of stem and cancer stem cells (e.g., marker positive, side - population, etc.) and the deposition of single cells.

It has been shown that the induction of an altered phenotype by a maternal protein restriction diet during pregnancy involves changes in DNA methylation and histone modifications in specific genes, including the glucocorticoid receptor (GR)(33 % lower; P < 0.001) and PPAR?

Not exact matches

The CNS related effects lead to two main phenotypes: adrenomyeloneuropathy, (AMN) characterized by progressive motor dysfunction, and cerebral ALD (cALD), characterized by severe neuroinflammation leading to early death.

The Rusalka variety has come about over several generations of selection by the grower who chose a particular pod phenotype at each successive grow - out.

Prenatally Diagnosed Cases of Binder Phenotype Complicated by Respiratory Distress in the Immediate Postnatal Period.

In Lausanne, the researchers carried out a detailed study of the genome and the «phenome» (the set of all phenotypes or clinical features) of a family of mice composed by 183 members.

The objective of the research project led by Marko Kallio, Principal Scientist at VTT, was to accelerate the drug development process by identifying new compounds that would possess similar binding properties and cellular phenotype, but a different chemical structure, as the selected drugs in clinical use or investigational compounds in development.

John Baines: «It appears that the skin flora is a phenotype that is partially controlled by the host genome variations.

«Phenocopy can be caused by other risk - modifying genes or exposure patterns that increase the probability of the specific phenotype manifesting itself,» says the study's first author Hildur Helgadottir, researcher at Karolinska Institutet's Department of Oncology - Pathology, Stockholm, Sweden.

First, they asked whether the number of potential mates encountered by males was associated with their phenotype (the spatial extent of their movement and body size).

«This new mechanism of Runx2 overexpression can give multiple myeloma cells a bone cell - like phenotype,» Yang said of the work by her lab and collaborators.

«The particular genetic risk conferred by these genes indicates that Southeast and Northeast Asians are highly susceptible to both phenotypes, while Africans are best protected against DSS and Europeans best protected against DF but the most susceptible to DSS,» the researchers say.

Iterating these unpredictable changes over hundreds or thousands of generations will inevitably lead to evolutionary changes in addition to any that come about by the preferential survival of certain phenotypes.

The relationship is non-linear because phenotype, or set of observable characteristics, is determined by a complex interplay between an organism's genes — tens of thousands of them, all influencing one another's behaviour — and its environment.

Genetic variation drives evolution by creating a range of phenotypes that might give individuals a competitive edge in different environments.

Laberge said the paradigm - shifting potential of intermittent dosing is based on the fact that it takes time for the inflammatory loop (fueled by the senescence - associated secretory phenotype or SASP) to form and time for it to re-establish itself after a brief treatment of rapamycin.

Careful attention to phenotyping diseases, facilitated by our knowledge of the human genome and computational analysis, has allowed observant physicians and physician - scientists to identify and categorize diseases in a manner that has informed basic science, given it new contexts, and in many instances provided important new directions for investigation.

Seahorse XF test kits and reagents simplify cellular bioenergetics by providing precalibrated, pretested reagents for metabolic phenotyping, mitochondrial respiration, glycolysis, and fatty - acid oxidation in cells.

EUMODIC was the first step towards the creation of a database of all mouse gene functions, a vision now being realized by the International Mouse Phenotyping Consortium (IMPC).

Some of these phenotypes can be partially transmitted by gut microbiota.»

The researchers are now planning to address the impact of targeting autophagy either clinically and pharmacologically on the immune landscape of melanomas by phenotyping other immune cells in the melanoma tumor microenvironment.

Dr. Islam's discovery was published [S. Islam, T. E. Carey, G. T. Wolf, M. J. Wheelock, and K. J. Johnson, «Expression of N - Cadherin by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell - cell adhesion,» J. Cell Biol.

«If human organs on chips can be shown to be robust and consistently recapitulate complex human organ physiology and disease phenotypes in unrelated laboratories around the world, as suggested by early proof - of - concept studies, then we will see them progressively replace one animal model at a time.

In addition, cohousing coprophagic mice harboring transplanted microbiota from discordant pairs provides an opportunity to determine which bacterial taxa invade the gut communities of cage mates, how invasion correlates with host phenotypes, and how invasion and microbial niche are affected by human diets.

Moreover, obese - phenotype mice were invaded by members of the Bacteroidales from the lean mice, but, happily, the lean animals resisted invasion by the obese microbiota.

Although studying genetic diversity in African populations tells us a great deal about human history, there is even more to learn by juxtaposing the genetic diversity with the diversity of heritable traits (phenotypes).

Surprisingly, they found that although the patterns of gene expression — as shown by the RNA sequencing — differed between the hepatocellular carcinomas and the liver cancers with biliary phenotype and depended on the histological type, the overall pattern of mutations in the cells was actually similar between the tumors — of either type — that had emerged in patients who had had infections with either hepatitis C or B, and were different in patients without such infections.

But by hierarchical clustering of observed alterations in endocytosis, the researchers identified two distinct cancer phenotype clusters, one marked by mutations in the oncogene KRAS in mesenchymal cells and the other by changes in epithelial cells.

Phevor works by using algorithms that combine the probabilities of gene mutations being involved in a disease with databases of phenotypes, or the physical manifestation of a disease, and information on gene functions.

For example, while insulin secretion failure is by far the most prevalent at - risk phenotype in normal weight subjects with prediabetes, fatty liver and visceral obesity become more prevalent in overweight and obese subjects.

They further investigated this phenotype in a skin tumor model system, provided by Maria Sibilia from the Institute for Cancer Research of the Medical University of Vienna, and found that deactivating HDAC1 actually accelerates tumor development, while HDAC2 deactivation has no effect.

Tan and other researchers in the laboratory of Georgia Tech Professor Lin Jiang tested that hypothesis using P. fluorescens, which rapidly evolves into two general phenotypes differentiated by the ecological niches they adopt in static test tube microcosms.

Neither the selective pressure nor the evolutionary response could have been identified with the methods used by the majority of studies that examine how wild populations respond to environmental changes, which predominantly concentrate on changes in the phenotype.