Knockdown of dynamin - binding protein or Tuba results in abnormal kidney development and other aberrant
phenotypes in zebrafish models (middle and right panels) compared with controls (left panel).
10:35 - 10:55 Johan Lindberg, Swetox and Jonathan Benskin, Stockholm University, Dept. Applied Environmental Science Molecular
phenotyping in zebrafish using metabolomics
High - throughput gene targeting and
phenotyping in zebrafish using CRISPR / Cas9.
Not exact matches
«Clinical
phenotype similarity
in megalencephalic leukoencephalopathy patients explained by
zebrafish model study.»
A novel 3D method of locomotor analysis
in adult
zebrafish: Implications for automated detection of CNS drug - evoked
phenotypes, Journal of Neuroscience Methods 255 (30), 66 - 74.
A novel 3D method of locomotor analysis
in adult
zebrafish: implications for automated detection of CNS drug - evoked
phenotypes.
Zebrafish ecology is,
in this regard, similar to golden shiners, whereby red
phenotypes do not exist and interaction with red - colored species is not documented [75].
In zebrafish, injection of low doses of both Tuba and Cdc42 antisense morpholinos, which had no effect when administered separately, led to severe
phenotypes similar to those seen following knockdown of other ciliary proteins.
Because knockdown of Tuba
in zebrafish affects cilia
in a number of organs, including the brain, a variety of aberrant
phenotypes were seen
in the Tuba knockdown
zebrafish model.
Using a
zebrafish model of DFNB63, we show that the auditory and vestibular
phenotypes are due to a lack of mechanotransduction (MET)
in Tomt - deficient hair cells.