Sentences with phrase «phenotypes observed»

In essence, this re-capitulated the tumor outgrowth phenotype observed for the parental d42m1 tumor.

Moreover, the coordinated expression of the 1918 virus genes most certainly confers the unique high - virulence phenotype observed with this pandemic virus.

Four research teams of I - Stem have joined forces in a collaborative project that has just achieved a first pilot therapy - oriented screen of compounds and RNA interference aiming at reversing the altered phenotypes observed in human embryonic stem cells carrying the mutant gene for myotonic dystrophy type 1.

ORDO is used for «naming» diseases e.g. «autosomal recessive limb girdle muscular dystrophy type 1», while HPO is used for describing the clinical phenotype observed in a patient e.g. «muscle weakness».

Furthermore, we found that the stem - like and EMT phenotypes observed in the cycling hypoxia - selected subpopulation are not reversible, because we obtained the same molecular profile from this subpopulation by culturing them as spherical cultures for several months in normal oxygen content and culturing them as adherent cells (Figure S2 in Additional file 2).

«Exploitation of the same habitat, but key differences at important times of the year, suggests that competition between a single species works to preserve the different phenotypes we observed - whilst simultaneously creating the potential for so - called sympatric speciation, i.e. the potential for a new species to form without geographic isolation,» says Hawley.

The disease is reminiscent of the choroidal hypoplasia phenotype observed in humans in conjunction with craniofacial or renal abnormalities.

We observed no statistically significant increase in SIRT1 activation when using the compounds at 0.1 or 10 μM, indicating that phenotypes observed for the use of RIPK2 inhibitors at these doses in cells are likely through SIRT1 - independent mechanisms when compared with the effect of resveratrol (Supplemental Fig. 6C).

In fact, we have previously showed that such defects in spermiogenesis were observed in the Rara - deficient mouse model and in response to 7 - day treatment with 5.0 mg of pan-RAR antagonist and resembled the phenotypes observed in VAD rat testes (2, 3, 6, 7, 20).