Sentences with word «phenotypic»
The word "phenotypic" refers to observable characteristics or traits of living organisms, such as physical appearances, behaviors, or abilities that can be seen or measured. It describes what we can observe about an organism based on its genetic makeup and how it interacts with its environment. Full definition
In genetics, heritability is the proportion of phenotypic variation in a population that is due to genetic variation.
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This substantial input of variation from wild ancestors has provided the raw material for phenotypic change, but unique development and genetic mechanisms may also have assisted the course of artificial selection.
Our findings show the significance for structural variations on phenotypic diversity and a novel role for HOXB8 in feather formation.
We did not observe phenotypic differences on MacConkey lactose plates, since the E. coli recipient strain has a deletion in lacZ, and thus, all of our isolates were Lac −.
All about the JAAWS research «Effects of Phenotypic Characteristics on the Length of Stay of Dogs at Two No Kill Animal Shelters.»
Identifying the molecular targets of compounds selected by phenotypic screens is typically burdensome and time - consuming.
Implementation of experimental procedures in cancerology and availability of 7 specialized laboratories of biosafety level BSL2 and BSL3, equipped with imaging (bioluminescence / fluorescence), surgery rooms with volatile anaesthesia, means of phenotypic characterization of immunodeficient mouse models, sensitization of murine tumours to radiotherapy and vectorized internal radiotherapy
Variation in genetic background may alter expression of the disease allele in affected animals, thus accounting for variation in phenotypic expression of the disease.
Near - isogenic lines for measuring phenotypic effects of DIMBOA - Glc methyltransferase activity in maize
«The generation of detailed phenotypic information for each knockout mouse strain will be a boon to disease researchers who want to determine the function of genes and to improve mouse models of human disease,» said NIH Director Francis S. Collins, M.D., Ph.D. «I am grateful to all of the people and programs across NIH who are supporting this effort and to our international partners who have joined us in this scientific endeavor.»
Because people exposed to Ebola show phenotypic variability in susceptibility to infection and disease severity, it is likely that human genetic variation contributes to individual immunity and infectivity and that host genetic differences are one factor among many that interact to influence the infection.
Such targets have recently been discovered in cell lines derived from aggressive childhood tumors using phenotypic profiling and RNAi screening.
Researchers describe phenotypic spectrum based on 83 affected children in Brazil.»
Previously, he led efforts at Abbott Laboratories and Monsanto to leverage rich, multi-omic datasets to predict phenotypic outcomes from genomic features.
Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC - associated factor X. Qin N, de Cubas AA, Garcia - Martin R, Richter S, Peitzsch M, Menschikowski M, Lenders JW, Timmers HJ, Mannelli M, Opocher G, Economopoulou M, Siegert G, Chavakis T, Pacak K, Robledo M, Eisenhofer G. Int J Cancer.
Mechanistically distinct pathways of divergent regulatory DNA creation contribute to evolution of human - specific genomic regulatory networks driving phenotypic divergence of Homo sapiens.
Projects are expected to focus on so - called phenotypic assays, which have unique translational potential through utilization of patient - derived primary cells.
The present study reports the Duffy blood group genotyping in P. vivax malaria patients from four different Brazilian endemic areas, exploring these significant phenotypic associations between blood group variants, as well as polymorphic regions of RBC receptors, with susceptibility or resistance to malaria.
«We were interested in understanding how such phenotypic heterogeneity can arise in situations in which the cells are genetically identical and are exposed to the same environmental conditions,» says Johannes Knebel, one of the joint first authors of the new paper.
Professor Segal's research has two major directions 1) Gene regulation — using quantitative and computational models to understand how DNA sequence variation among human individuals generates phenotypic diversity 2) Microbiome and Nutrition — understanding how the microbial composition of individuals affect their physiology and health.
Although phenotypic consequences, referred to here as biallelic effects, resulting from two different mutant alleles in compound heterozygote patients have been postulated, such effects have historically been difficult to distinguish from the influence of environment and genetic background.
Ultimately, given that we are able to detect little phenotypic impact where there are vast amounts of DNA turnover, our findings support lower estimates for the functional proportion of the human genome.
Although Old World mouth - brooding haplochromine cichlids exhibited phenotypic plasticity, the magnitude of head - shape plasticity observed was greater in the New World substrate - spawning cichlid, H. cyanoguttatum.
We do this because reducing variability means that we will have greater power in our statistics to show phenotypic differences and ultimately be able to use fewer animals.
To investigate the history of domestic horses with respect to this charismatic phenotypic character, the scientists analysed a dataset of 201 samples of ancient horse DNA.
The work has focused on domestic animals as models for phenotypic evolution and resulted in a steady stream of interesting findings on genotype - phenotype relationships.
There aren't many differences between populations — there are more differences within populations, and we tend to forget that, on both genetic and phenotypic levels.»
Phenotypic rescue of unc - 7 by various constructs was assessed by tapping transformed animals on the nose or tail and observing whether or not smooth sinusoidal waves were propagated.
But it's also known that changing conditions can prompt immediate shifts in organisms» physical traits — or what researchers call phenotypic plasticity, which allows for different looking organisms without changing their genetic code.
«In this way, the spores obtain a stable phenotypic memory of the growth and gene expression history of their progenitor cells, which influences their future.
Further phenotypic characterization revealed that LKB1 is required for the differentiation and maintenance of two NCC - derivatives, Schwann cells and the ENS. Using a model of neural crest stem cell line, we demonstrated that Lkb1 is key for neural crest - derived glial commitment.
In a previous study (Mäki et al, 2002) on the same breeds and data sets, no indication of major genes was found based on within - sire phenotypic distributions of the left hip and elbow joints of the dogs.