Sentences with phrase «phenotypic assays»

Through the development of phenotypic assays and high throughput screening (HTS) thousands of compounds have been identified that inhibit the most serious malaria parasite, Plasmodium falciparum.

Evaluation of these in phenotypic assays has the potential to discover important pathways or targets connected to key pathophysiological processes.

Projects are expected to focus on so - called phenotypic assays, which have unique translational potential through utilization of patient - derived primary cells.

In this role, she focuses on the development of biologically relevant high throughput biochemical and phenotypic assays to enable high throughput screening (HTS) for a variety of drug targets for psychiatric disorders, and is currently interested in developing a high throughput calcium dynamics assay to monitor synaptic networks.

Not exact matches

Here, the authors have done the difficult and time - consuming work of (1) exhaustive sequencing to identify the possible functional variants, and (2) in vivo functional assays to prove that the implicated variants have a phenotypic effect.

Phenotypic stability and unlimited self - renewal capacity of cell derived from pluripotent stem cells are essential properties for cell assay development for High Throughput Screening (HTS) strategies.

Shao L, Campbell U, Fang K, Powell AN, Campbell JE, Jones PG, Hanania T, Alexandrov V, Morganstern I, Sabath E, Zhong MH, Large HT, Spear KL In Vivo Phenotypic Drug Discovery: Applying a Behavioral Assay to the Discovery and Optimization of Novel Antipsychotic Agents.

Further, chemicals that screened positive in the BRET assay also stimulated phenotypic outcomes in daphnids that result from MfR signaling.

In addition to conventional assays, these readers enable phenotypic screening of cells, either by well or per cell.

However, phenotypic cell - based assays are now becoming more commonplace.