Sentences with phrase «phenotypic change»

This substantial input of variation from wild ancestors has provided the raw material for phenotypic change, but unique development and genetic mechanisms may also have assisted the course of artificial selection.

This suggests that for the most part the accumulation of DNA gains and losses have had little impact on phenotypic change.

Uncovering the genomic bases of phenotypic change in the NGS era Organizers: Manuel Irimia, Ignacio Maeso, Juan Pascual - Anaya Sponsor Living fossils, myth or reality?

Although protein is highly conserved in evolution, previous mtEF4 gene knockouts in some model organisms did not show significant phenotypic change.

At present, and based on what we know of the genetic regulation of development, these phenotypic changes in the gut are most likely the result of positive genetic changes in the genetic regulatory pathways controlling the development of the relevant anatomical features, i.e. they are novel positive, heritable genetic features producing a specific and functional novel anatomical structure within the Genus.

Finally, transformation may provide a general approach to the analysis of complex heritable phenotypes by permitting the distinction between phenotypic changes without concomitant changes in DNA and functional genetic rearrangements.

Aneuploidy is responsible for the observed phenotypic changes, as chromosome loss restoring euploidy results in a wild - type phenotype.

Among 90 isolates generated from the selfing of this α + SXI2a self - fertile strain, seven strains exhibited phenotypic changes compared to the parental strain (Figure S14).

Among 11 strains that had the most overt phenotypic changes, four were aneuploid and no other aneuploids were detected in the larger progeny set (Figure 9A).

We are known for our cutting edge translational approach to research, our customized solutions, the breadth and quality of our work, as well as for our ability to identify statistically relevant phenotypic changes, even early and subtle changes, that help our clients quantify the efficacy of their treatments before they move into the clinic.

Acclimatization refers to phenotypic changes by an organism to stresses in the natural environment that result in the readjustment of the organism's tolerance.

Transient in utero disruption of Cystic Fibrosis Transmembrane Conductance Regulator causes phenotypic changes in Alveolar Type II cells in adult rats.

The approach to target validation utilizes RNAi, CRISPR, and ORF expression platforms to genetically perturb candidate target gene expression in relevant cancer cell lines, and then profile the resulting phenotypic changes with regard to their effect on various biochemical pathways.

Fixed mutations and structural genomic variations were found potentially linked to the phenotypic changes observed.

Cellular senescence is a state of stable cell growth arrest that is accompanied by drastic molecular and phenotypic changes.

We found that initial phenotypic changes (non-heritable changes) appear to facilitate the genetic assimilation of changes.

«Future efforts to preserve or restore aging - and disease - related loss of lung function will need to take such tissue mechanical and cellular phenotypic changes into account,» the researchers wrote.

Fishes constitute a highly diverse group of vertebrates that exhibit deep phenotypic changes during development.

These dynamics are the basis for models that predict the evolution of clade frequencies, as well as broad genetic and phenotypic changes.

The objective was to assess whether the breed retains enough genetic diversity to correct the genotypic and phenotypic abnormalities associated with poor health, to allow for the elimination of deleterious recessive mutations, or to make further phenotypic changes in body structure or coat.

Not exact matches

It also emphasizes how difficult it can be to clearly connect specific DNA changes with particular clinical or phenotypic outcomes.

It has been speculated that such heterogeneous production of signaling molecules could be advantageous for the whole population because it allows for a division of labor between signal producers and non-producers, or because the creation of phenotypic diversification provides greater evolutionary flexibility and enables populations to adapt more rapidly to environmental change.

The results show the plants have great phenotypic plasticity and do not all change in the same ways.

Zachariah Gezon, a Ph.D. student in Ecology and Evolutionary Biology at Dartmouth College, studied the impact of early snow removal on a native mustard plant as part of a study looking at climate change and phenotypic plasticity.

«Because climate change affects some environmental factors like precipitation and temperature but not others like day length, phenotypic plasticity could allow some species to persist in a habitat despite changing conditions and provide more time for them to evolve and migrate,» says co-author Zachariah Gezon, a Ph.D. student in Ecology and Evolutionary Biology at Dartmouth.

Phenotypic plasticity is an organism's ability to change in response to the environment, causing genetically identical organisms to look very different when they live in different conditions.

The extreme phenotypic diversity observed among modern domestic dogs is unique among mammalian species, and as such, it offers unique insight regarding both the constraints and potential of evolutionary change under domestication.

The largest numbers of variants identified by genome - wide association are copy - number changes, which have a greater phenotypic effect than do single nucleotide polymorphisms.

Plant from multiple species, seed sources, and climate zones, particularly from locally - adapted sources Manage to maintain genetic diversity and phenotypic plasticity Create opportunities for rapid natural selection for species with high predicted potential for adverse impacts from climate change (Sturrock et al. 2011; Erickson et al. 2012; Alfaro et al. 2014; FAO 2014) Plant drought tolerant and native species Retain diversity of species and promote legacy trees Manage or restore mosaic (variable pattern of species and ages) and maintain or improve landscape connectivity Plant in asynchronous rotations and manage for diverse age classes Thin, plant, and use prescribed fire to favor species adapted to disturbance (Millar et al. 2007; Vose et al. 2016; Keane et al. forthcoming)

This phenotypic diversity is often the result of changes or loss of ancestral phenotypes or gain of novel phenotypes during evolution.

But in the course of his work, detailed phenotypic characterisation of biopsy samples led him to an unexpected conclusion: «The traditional view is that Barrett's glands develop from the normal lining of the oesophagus, but actually, they look really similar to pre-cancerous changes seen in the stomach lining,» Stuart says.

Jennifer L. Kelley, Pauline F. Grierson, Peter M. Davies & Shaun P. Collin — 2017 (4)([email protected]) Keywords: climate change, contemporary evolution, phenotypic plasticity, sensory adaptation.

The significant changes reinforced the impact of the genetic background to various phenotypic analysis, even using nearly divergent substrains.

Susan A. Foster 2013 (6)([email protected]) Keywords: anthropogenic environmental change, behavioural phenotype, contemporary evolution, evolutionary mismatch, geographic variation, phenotypic plasticity

Finally, we collaborate with Lauren Chapman of McGill University (Montreal, Canada) to study the role of phenotypic plasticity (changes induced by the environment) and genetic assimilation in the process of adaptation and evolutionary change of cichlid fishes.

Age - dependent changes in phenotypic variance have been associated to a decline in regulatory functions leading to increase in disease risk.

The focus of the conference was connecting how epigenetics (cellular and physiological phenotypic trait variations that are caused by external or environmental factors that switch genes on and off and affect how cells read genes instead of being caused by changes in the DNA sequence — in other words nutrition and lifestyle choices) impact whether or not an individual actually develops a specific health issue even though they have a SNP mutation.

There are multiple environmental factors such as caloric intake, level of exercise, and weather that can affect the severity of clinical signs and phenotypic expression (radiographic changes).

Natural spatial and temporal variability in the pH / pCO2 conditions experienced by marine populations provide the potential for different levels of adaptation (genetic) and acclimatization (phenotypic) to decreased pH and elevated pCO2, emphasizing the importance of understanding physiological variation existing along natural environmental gradients (macrophysiology) in understanding global change impacts [29].

Moreover, for the first time, they show that changes in whole - organism phenotypic responses are accompanied by changes in the expression of genes related to intracellular regulatory processes rather than genes thought to be essential for calcification.

(iii) Can organisms» capacity for phenotypic buffering and adaptation offset the consequences of environmental change?