Sentences with phrase «phenotypic changes»

During treatment with RIPK2 inhibitor 1 (and post-treatment), we did not overtly observe phenotypic changes in these animals nor notice evidence of health conditions to support a creatine kinase abnormality (such as skeletal muscle defect and movement abnormalities or unexpected euthanasia due to a cardiac abnormality).

Aneuploidy is responsible for the observed phenotypic changes, as chromosome loss restoring euploidy results in a wild - type phenotype.

«You can not only evaluate changes such as cells dying, for example, but you can also see more subtle phenotypic changes between different [conditions],» adds Sirenko.

The objective was to assess whether the breed retains enough genetic diversity to correct the genotypic and phenotypic abnormalities associated with poor health, to allow for the elimination of deleterious recessive mutations, or to make further phenotypic changes in body structure or coat.

Uncovering the genomic bases of phenotypic change in the NGS era Organizers: Manuel Irimia, Ignacio Maeso, Juan Pascual - Anaya Sponsor Living fossils, myth or reality?

Finally, transformation may provide a general approach to the analysis of complex heritable phenotypes by permitting the distinction between phenotypic changes without concomitant changes in DNA and functional genetic rearrangements.

Although protein is highly conserved in evolution, previous mtEF4 gene knockouts in some model organisms did not show significant phenotypic change.

But even if it doesn't, that might not matter for developing an anti-obesity drug, says diabetologist Barry Goldstein of Thomas Jefferson University in Philadelphia: «The fact that the results are so clean, that there are apparently no other phenotypic changes, makes [PTP - 1B] a very exciting drug target.»

We are known for our cutting edge translational approach to research, our customized solutions, the breadth and quality of our work, as well as for our ability to identify statistically relevant phenotypic changes, even early and subtle changes, that help our clients quantify the efficacy of their treatments before they move into the clinic.

This suggests that for the most part the accumulation of DNA gains and losses have had little impact on phenotypic change.

Gliosis is a non-stereotypical response of glia associated with a pathological state that serves as an umbrella term describing various phenotypic changes.

Acclimatization refers to phenotypic changes by an organism to stresses in the natural environment that result in the readjustment of the organism's tolerance.

To address these questions, we are developing and improving comparative genomics approaches such as Forward Genomics to associate phenotypic changes between species to changes in genomic elements.

The approach to target validation utilizes RNAi, CRISPR, and ORF expression platforms to genetically perturb candidate target gene expression in relevant cancer cell lines, and then profile the resulting phenotypic changes with regard to their effect on various biochemical pathways.

We found that initial phenotypic changes (non-heritable changes) appear to facilitate the genetic assimilation of changes.

«Future efforts to preserve or restore aging - and disease - related loss of lung function will need to take such tissue mechanical and cellular phenotypic changes into account,» the researchers wrote.

Results from these studies will broaden our limited understanding on how single - cells age by elucidating which genetic and phenotypic changes accompany the aging process.

While it is possible to overwrite genome - level alterations and undo phenotypic changes using immunizing reversal drives [37], these countermeasures must necessarily spread to the entire population in order to immunize them against the unwanted drive system; strategies based on pure reversal drives [38] or variations such as gene drive «brakes» [39] will only slow it down.

Previous studies on foxes [7] and rats [8,9] have shown that strong selection for tameness can be associated with the peculiar phenotypic changes that are typical for domesticated animals.

Most strain ‐ specific changes were apparent early in the regimen when phenotypic changes were already set, but not yet verypronounced and they allow a clear discrimination of the mouse strains at an early stage during the long ‐ term high ‐ fat diet.

This substantial input of variation from wild ancestors has provided the raw material for phenotypic change, but unique development and genetic mechanisms may also have assisted the course of artificial selection.

The objective of the study, according to the researchers, was to assess whether the breed retains enough genetic diversity to correct the genotypic and phenotypic abnormalities associated with poor health, to allow for the elimination of deleterious recessive mutations, or to make further phenotypic changes in body structure or coat.

Although the two genomes of cells undergoing α - α unisexual reproduction are identical, phenotypic changes to these and other conditions (Figure S4) are clearly evident in even a relatively small sample of progeny produced by this process, which indicates that α - α unisexual reproduction generates phenotypic plasticity de novo since there is no preexisting genetic diversity to admix.

Cellular senescence is a state of stable cell growth arrest that is accompanied by drastic molecular and phenotypic changes.