Sentences with phrase «phenotypic changes in»

The objective was to assess whether the breed retains enough genetic diversity to correct the genotypic and phenotypic abnormalities associated with poor health, to allow for the elimination of deleterious recessive mutations, or to make further phenotypic changes in body structure or coat.

Transient in utero disruption of Cystic Fibrosis Transmembrane Conductance Regulator causes phenotypic changes in Alveolar Type II cells in adult rats.

At present, and based on what we know of the genetic regulation of development, these phenotypic changes in the gut are most likely the result of positive genetic changes in the genetic regulatory pathways controlling the development of the relevant anatomical features, i.e. they are novel positive, heritable genetic features producing a specific and functional novel anatomical structure within the Genus.

Uncovering the genomic bases of phenotypic change in the NGS era Organizers: Manuel Irimia, Ignacio Maeso, Juan Pascual - Anaya Sponsor Living fossils, myth or reality?

Not exact matches

Finally, transformation may provide a general approach to the analysis of complex heritable phenotypes by permitting the distinction between phenotypic changes without concomitant changes in DNA and functional genetic rearrangements.

The results show the plants have great phenotypic plasticity and do not all change in the same ways.

Zachariah Gezon, a Ph.D. student in Ecology and Evolutionary Biology at Dartmouth College, studied the impact of early snow removal on a native mustard plant as part of a study looking at climate change and phenotypic plasticity.

«Because climate change affects some environmental factors like precipitation and temperature but not others like day length, phenotypic plasticity could allow some species to persist in a habitat despite changing conditions and provide more time for them to evolve and migrate,» says co-author Zachariah Gezon, a Ph.D. student in Ecology and Evolutionary Biology at Dartmouth.

Although protein is highly conserved in evolution, previous mtEF4 gene knockouts in some model organisms did not show significant phenotypic change.

Phenotypic plasticity is an organism's ability to change in response to the environment, causing genetically identical organisms to look very different when they live in different conditions.

Aneuploidy is responsible for the observed phenotypic changes, as chromosome loss restoring euploidy results in a wild - type phenotype.

Among 11 strains that had the most overt phenotypic changes, four were aneuploid and no other aneuploids were detected in the larger progeny set (Figure 9A).

Acclimatization refers to phenotypic changes by an organism to stresses in the natural environment that result in the readjustment of the organism's tolerance.

Plant from multiple species, seed sources, and climate zones, particularly from locally - adapted sources Manage to maintain genetic diversity and phenotypic plasticity Create opportunities for rapid natural selection for species with high predicted potential for adverse impacts from climate change (Sturrock et al. 2011; Erickson et al. 2012; Alfaro et al. 2014; FAO 2014) Plant drought tolerant and native species Retain diversity of species and promote legacy trees Manage or restore mosaic (variable pattern of species and ages) and maintain or improve landscape connectivity Plant in asynchronous rotations and manage for diverse age classes Thin, plant, and use prescribed fire to favor species adapted to disturbance (Millar et al. 2007; Vose et al. 2016; Keane et al. forthcoming)

The approach to target validation utilizes RNAi, CRISPR, and ORF expression platforms to genetically perturb candidate target gene expression in relevant cancer cell lines, and then profile the resulting phenotypic changes with regard to their effect on various biochemical pathways.

But in the course of his work, detailed phenotypic characterisation of biopsy samples led him to an unexpected conclusion: «The traditional view is that Barrett's glands develop from the normal lining of the oesophagus, but actually, they look really similar to pre-cancerous changes seen in the stomach lining,» Stuart says.

Finally, we collaborate with Lauren Chapman of McGill University (Montreal, Canada) to study the role of phenotypic plasticity (changes induced by the environment) and genetic assimilation in the process of adaptation and evolutionary change of cichlid fishes.

Age - dependent changes in phenotypic variance have been associated to a decline in regulatory functions leading to increase in disease risk.

The focus of the conference was connecting how epigenetics (cellular and physiological phenotypic trait variations that are caused by external or environmental factors that switch genes on and off and affect how cells read genes instead of being caused by changes in the DNA sequence — in other words nutrition and lifestyle choices) impact whether or not an individual actually develops a specific health issue even though they have a SNP mutation.

Natural spatial and temporal variability in the pH / pCO2 conditions experienced by marine populations provide the potential for different levels of adaptation (genetic) and acclimatization (phenotypic) to decreased pH and elevated pCO2, emphasizing the importance of understanding physiological variation existing along natural environmental gradients (macrophysiology) in understanding global change impacts [29].

Moreover, for the first time, they show that changes in whole - organism phenotypic responses are accompanied by changes in the expression of genes related to intracellular regulatory processes rather than genes thought to be essential for calcification.