Sentences with phrase «phenotypic heterogeneity»
Some reasons for this relatively low yield include unappreciated phenotypic heterogeneity; locus heterogeneity; somatic and germline mosaicism; variants of uncertain functional significance; technically inaccessible areas of the genome; incorrect mode of inheritance investigated; and inadequate communication between clinicians and basic scientists with knowledge of particular genes, proteins, or biological systems.
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The difficulty in gene identification is possibly related to the fact that AD is a complex disease characterized by marked phenotypic heterogeneity.
«Given that phenotypic heterogeneity within a bacterial population can increase its advantage of survival under stress conditions such as antibiotic treatment, this new technique is quite promising for future treatment of bacterial pathogens, as it enables de novo detection and characterization of epigenetic heterogeneity in a bacterial population.»
Not exact matches
Therefore, it is more than evident that fetal structural malformations and other fetal abnormalities revealed through prenatal ultrasound are characterized by considerable phenotypic and genetic heterogeneity.
IRDs offer a number of advantages for studies like this due to exceptional phenotypic, genetic, and allelic heterogeneity.
To translate advances in our understanding of molecular mechanisms of oncogenesis and tumor progression into novel therapeutic strategies.With primary focus on lung cancer, melanoma, and lymphoma / leukemia, we will use the strength of in - depth molecular and phenotypic characterization of tumor heterogeneity to identify new targets and translate those into new therapeutic opportunities.