Sentences with phrase «phenotypic impact»

Our final goal is to understand the phenotypic impact of all these variants by making use of well defined organisms and the fine scale exploration of all of variants.

Thus, these animals exhibit premature cardiac arrhythmias and stiffening of the arterial wall, and cardiac failure appears to be the main cause of death; yet these tissues are not burdened with an abnormally - high burden of p16Ink4a - senescent cells, and accordingly, ablation p16Ink4a - positive senescent cells in these animals had little tissue - specific or survivorship phenotypic impact.

This SNP in bsl1 - 2 was intriguing since it does not disrupt a canonical splice site and would otherwise have been overlooked in a screen for SNPs with high likelihood of having a phenotypic impact.

Ultimately, given that we are able to detect little phenotypic impact where there are vast amounts of DNA turnover, our findings support lower estimates for the functional proportion of the human genome.

Not exact matches

Zachariah Gezon, a Ph.D. student in Ecology and Evolutionary Biology at Dartmouth College, studied the impact of early snow removal on a native mustard plant as part of a study looking at climate change and phenotypic plasticity.

The phenotypic memory has a major impact on spore development.

Phenotypic and proteomic characteristics of human dental pulp derived mesenchymal stem cells from a natal, an exfoliated deciduous, and an impacted third molar tooth.

This suggests that for the most part the accumulation of DNA gains and losses have had little impact on phenotypic change.

Plant from multiple species, seed sources, and climate zones, particularly from locally - adapted sources Manage to maintain genetic diversity and phenotypic plasticity Create opportunities for rapid natural selection for species with high predicted potential for adverse impacts from climate change (Sturrock et al. 2011; Erickson et al. 2012; Alfaro et al. 2014; FAO 2014) Plant drought tolerant and native species Retain diversity of species and promote legacy trees Manage or restore mosaic (variable pattern of species and ages) and maintain or improve landscape connectivity Plant in asynchronous rotations and manage for diverse age classes Thin, plant, and use prescribed fire to favor species adapted to disturbance (Millar et al. 2007; Vose et al. 2016; Keane et al. forthcoming)

As the form of hypertension can differ between strains, researchers need to not only be aware of the form of hypertension that the individual strain exhibits but also the impact that a particular type of diet may have on the phenotypic response.

-- 1) Improved understanding of adaptive genetic and phenotypic forest characteristics that would provide better guidance for breeding programs and management actions to maximize resilience to both direct and indirect climate impacts to forests; 2) Long - term studies to better understand effects of CO2 fertilization in Montana's forests; 3) Improved models of climate and vegetation effects on evapotranspiration and water balances throughout forested systems.

The significant changes reinforced the impact of the genetic background to various phenotypic analysis, even using nearly divergent substrains.

The focus of the conference was connecting how epigenetics (cellular and physiological phenotypic trait variations that are caused by external or environmental factors that switch genes on and off and affect how cells read genes instead of being caused by changes in the DNA sequence — in other words nutrition and lifestyle choices) impact whether or not an individual actually develops a specific health issue even though they have a SNP mutation.

OBJECTIVE The purpose of the study was to investigate the combined impact of hormone replacement therapy (HRT) and active lifestyle on the phenotypic profile and in vitro activities of specific

Assuming that there is a will to improve the overall health of English bulldogs, the question raised by this study is whether or not there is sufficient genotypic diversity remaining in the breed to allow «reverse genetics» to correct phenotypic abnormalities that have major impacts on health.

Any projected adverse impacts of rising temperatures or declining seawater and freshwater pH levels («acidification») will be largely mitigated through phenotypic adaptation or evolution during the many decades to centuries it is expected to take for pH levels to fall.

Natural spatial and temporal variability in the pH / pCO2 conditions experienced by marine populations provide the potential for different levels of adaptation (genetic) and acclimatization (phenotypic) to decreased pH and elevated pCO2, emphasizing the importance of understanding physiological variation existing along natural environmental gradients (macrophysiology) in understanding global change impacts [29].