Sentences with phrase «phenotypic levels»

There aren't many differences between populations — there are more differences within populations, and we tend to forget that, on both genetic and phenotypic levels.»

Despite this positive correlation at the phenotypic level, however, a converse causal relationship was evident on the genotypic level.

First, FR - EXT was defined at a phenotypic level and was based on family history as a proxy for genetic vulnerability.

Not exact matches

To sum up, if the cecal valves were simply the result of phenotypic plasticity, we would expect to see them more frequently in at least the Family level.

A strategic focus is to continue to develop computational tools (such as KinomeXplorer, NetworKIN, and NetPhorest) and to deploy these on genome - scale quantitative data obtained by, for example, mass spectrometry, genomic, and phenotypic screens to understand the principles of how spatio and temporal assembly of mammalian signaling networks transmit and process information at a systems level in order to alter cell behavior.

Mating pairs often exhibit levels of similarity in phenotypic or genotypic traits that differ systematically from the level expected under random mating, produced by assortative mating.

Implementation of experimental procedures in cancerology and availability of 7 specialized laboratories of biosafety level BSL2 and BSL3, equipped with imaging (bioluminescence / fluorescence), surgery rooms with volatile anaesthesia, means of phenotypic characterization of immunodeficient mouse models, sensitization of murine tumours to radiotherapy and vectorized internal radiotherapy

Our facility houses two third - generation Helios mass cytometers that can routinely analyze more than 40 markers per tube to provide an unprecedented «systems - level» view of phenotypic and functional variations among single cells within heterogeneous cell populations.

Set up to overcome the siloing, fragmentation and inaccessibility of datasets from different projects, it links omics data with phenotypic data and information in registries and biobanks at both an individual ‐ patient and whole ‐ cohort level to enable researchers to analyse their own data and gain a complete view of their disease and patient population of interest.

Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise

Phenotypic characterizations reveal high levels of CD44, α2β1 integrin, and β - catenin expression in holoclones, whereas meroclones and paraclones show markedly reduced expression of these stem cell markers.

Interestingly, it has been reported that reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Kap1, cause an increased phenotypic noise, suggesting that faithful epigenetic control of transcription is central to suppressing deleterious levels of phenotypic variation [43].

A group of well - known companies aims to be the first to analyse brain scans together with genomic, clinical and phenotypic data to study neurodegenerative diseases at a population level, then distil it down to an individual's personal treatment plan.

There are multiple environmental factors such as caloric intake, level of exercise, and weather that can affect the severity of clinical signs and phenotypic expression (radiographic changes).

Any projected adverse impacts of rising temperatures or declining seawater and freshwater pH levels («acidification») will be largely mitigated through phenotypic adaptation or evolution during the many decades to centuries it is expected to take for pH levels to fall.

Natural spatial and temporal variability in the pH / pCO2 conditions experienced by marine populations provide the potential for different levels of adaptation (genetic) and acclimatization (phenotypic) to decreased pH and elevated pCO2, emphasizing the importance of understanding physiological variation existing along natural environmental gradients (macrophysiology) in understanding global change impacts [29].