Sentences with phrase «phenotypic screens»

The metabolic exploration platform of ICS performs specific, on - demand experiments as well as comprehensive metabolic analyses with primary and secondary phenotypic screens to evaluate in vivo the energy balance in mouse.

«Phenotypic screens are probably underutilized for identifying drug targets and potential compounds,» says Daniel Tardiff, a scientist in the Lindquist lab and lead author of one of the Science papers.

To overcome this limitation, the lab of Whitehead Member Susan Lindquist has turned to phenotypic screens in which candidate compounds are studied within a living system.

The expansion of the KCGS, combined with its use in diverse disease - relevant phenotypic screens and the sharing of the resulting data in the public domain, is the best mechanism for reaching this goal.

Identifying the molecular targets of compounds selected by phenotypic screens is typically burdensome and time - consuming.

A strategic focus is to continue to develop computational tools (such as KinomeXplorer, NetworKIN, and NetPhorest) and to deploy these on genome - scale quantitative data obtained by, for example, mass spectrometry, genomic, and phenotypic screens to understand the principles of how spatio and temporal assembly of mammalian signaling networks transmit and process information at a systems level in order to alter cell behavior.

Indeed, their combined phenotypic screening and target - identification approach enabled them to quickly discover, characterize and carry out preclinical tests of a potential new drug for obesity - linked diabetes: a complex metabolic disorder that affects 347 million people worldwide.

The scientists started with a phenotypic screen, testing their library of compounds for the ability to make young fat cells mature faster and store more fat.

A Singapore - India collaborative research project between the Singapore University of Technology & Design (SUTD) and CSIR - National Chemical Laboratories (NCL) completed phenotypic screening of a large collection of potent chemical inhibitors (known as MMV Malaria Box), against pathogenic parasites Toxoplasma gondii and Plasmodium falciparum, causative agents of human toxoplasmosis and malaria.

Phenotypic screening allows us to see how similar and how different they are.»

Identification of a farnesol analog as a Ras function inhibitor using both an in vivo Ras activation sensor and a phenotypic screening approach.

Phenotypic screening is an important research tool and underlies most first - in - class drugs.

iTeos has developed an innovative phenotypic screening platform that is applied to the identification of rational combinations for our current programs, and to the discovery of novel targets for immuno - oncology.

Phenotypic screening is used routinely in drug discovery for the identification of substances that alter the phenotype of a cell or an organism.

«The knockout mice were subjected to a broad, unbiased phenotypic screen aimed at identifying potential defects in general metabolism, in bone metabolism, or in the function of the cardiovascular, the immune or the neural systems.»

Phenotypic screening of small molecule libraries using iPSC - based models to identify novel drug candidates and disease mechanisms.

In addition to conventional assays, these readers enable phenotypic screening of cells, either by well or per cell.

Not exact matches

In this role, she focuses on the development of biologically relevant high throughput biochemical and phenotypic assays to enable high throughput screening (HTS) for a variety of drug targets for psychiatric disorders, and is currently interested in developing a high throughput calcium dynamics assay to monitor synaptic networks.

An older strategy, «phenotypic» screening, avoids much of this problem by testing compounds for their ability to produce a desired effect directly on living cells.

Subjecting N. gonorrhoeae to the phenotypic microarray screening method for the first time, Sikora's team focused on seven proteins from the bacteria's cell envelope, which consists of the outer membrane, the cell wall and the inner membrane.

Such targets have recently been discovered in cell lines derived from aggressive childhood tumors using phenotypic profiling and RNAi screening.

Phenotypic stability and unlimited self - renewal capacity of cell derived from pluripotent stem cells are essential properties for cell assay development for High Throughput Screening (HTS) strategies.

Phenotypic approaches screen for the effects of small molecules on an observable characteristic of an animal, tissue or cell model, typically without a priori knowledge of the target.

This SNP in bsl1 - 2 was intriguing since it does not disrupt a canonical splice site and would otherwise have been overlooked in a screen for SNPs with high likelihood of having a phenotypic impact.

Through the development of phenotypic assays and high throughput screening (HTS) thousands of compounds have been identified that inhibit the most serious malaria parasite, Plasmodium falciparum.

Further, chemicals that screened positive in the BRET assay also stimulated phenotypic outcomes in daphnids that result from MfR signaling.

As part of the global effort toward malaria eradication, phenotypic whole - cell screening revealed the 2 - aminopyridine class of small molecules as a good starting point to develop new antimalarial drugs.

Some screening tests are based on phenotypic evaluation, others on genetic testing.

Phenotypic factor analyses of a seven - item eating pathology screening tool yielded two factors: weight and shape concerns and behaviors (WSCB) and binge eating (BE).