Sentences with phrase «phenotypic variation»

The observable phenotypic variation was pores per square inch on the skin.

This introgression could have provided early dogs living in high latitudes with phenotypic variation beneficial for adaption to a new and challenging environment.

«Phenotypic variation in humans isn't as simple as we thought it would be,» Hernandez said.

Interestingly, it has been reported that reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Kap1, cause an increased phenotypic noise, suggesting that faithful epigenetic control of transcription is central to suppressing deleterious levels of phenotypic variation [43].

Our study outlines the major sources of genetic and phenotypic variation in iPS cells and establishes their suitability as models of complex human traits and cancer.

Heightened phenotypic variation and age - based fading of ultraviolet butterfly wing coloration.

We know, of course, that noncoding portions of the human genome contain functional elements contributing to phenotypic variation.

From 2008 - 2010, he was supported by the CGGH to study phenotypic variation in the drug sensitivity of Plasmodium falciparum isolates collected Kilifi District, and to investigate genotype - phenotype associations using genome sequencing data generated on these isolates at the Wellcome Trust Sanger Institute.

The identification of CNVs in the discordant twins provides an additional potential explanation for phenotypic variation within MZ twin pairs.

Our group is interested in understanding how genetic factors interact with other non-genetic and so - called epigenetic factors to determine such phenotypic variation.

She is particularly concerned with assessing the role that fossils play in the interpretation of modern biodiversity and phylogenetics, as well as the role that phenotypic variation plays in the interpretation of vertebrate fossils and systematics.

Applications of next - generation sequencing, combined with powerful yeast genetics, now create tremendous opportunities to investigate both global contributions and specific roles of ncRNAs in genome regulation and phenotypic variation.

We are particularly interested in assessing whether the majority of phenotypic variation among breed - affiliated dogs is a consequence of QTLs of large effect or whether much of the variation is attributable to many QTLs of modest or small effect.

We performed artificial selection on the allometry between forewing area and body size in a butterfly to test for developmental constraints, and then used the resultant increased range of phenotypic variation to quantify natural selection on the scaling relationship.

In genetics, heritability is the proportion of phenotypic variation in a population that is due to genetic variation.

Non-European populations are critical to study to find mutations that may be underlying the vast phenotypic variation of humans.»

The contribution of Neanderthals to phenotypic variation in modern humans.

A genome - wide association study (GWAS) of 1570 Africans identified variants significantly associated with skin pigmentation, which clustered in four genomic regions that together account for almost 30 % of the phenotypic variation.

Future studies should elucidate the molecular and cellular mechanisms by which regional environment controls phenotypic variations of neuronal types.

«Finally, as environmental factors that affect the susceptibility, triggering and progression of ALS remain largely unknown, we contend future studies are needed to evaluate longitudinal trends in exposure measurements, assess newer and nonpersistent chemicals, consider pathogenic mechanisms, and assess phenotypic variations,» the study conclude.

A recent chapter, «Genetic and phenotypic variations of inherited retinal disease in dogs: The power of within - and across - breed studies» by Miyadera, Acland & Aguirre provides a useful review of this topic (2).

There has been renewed interest in the subject of «abnormal» bone lengths, joints, angles between limbs, and related phenotypic variations from what I have called «the ancestral type.»

Not exact matches

Furthermore, the analysis of data on single - nucleotide polymorphisms, the main cause of difference between human beings, allows the prediction of phenotypic effects of a particular genetic variation.

Our findings show the significance for structural variations on phenotypic diversity and a novel role for HOXB8 in feather formation.

With this unique resource in hand, we have already characterized several candidate structural variation which show evidence for phenotypic adaptation, which can function to drive species evolution,» said Emerson.

Evolutionary studies of mammalian teeth have generally concentrated on the adaptive and functional significance of dental features, whereas the role of development on phenotypic generation and as a source of variation has received comparatively little attention.

Because people exposed to Ebola show phenotypic variability in susceptibility to infection and disease severity, it is likely that human genetic variation contributes to individual immunity and infectivity and that host genetic differences are one factor among many that interact to influence the infection.

Professor Segal's research has two major directions 1) Gene regulation — using quantitative and computational models to understand how DNA sequence variation among human individuals generates phenotypic diversity 2) Microbiome and Nutrition — understanding how the microbial composition of individuals affect their physiology and health.

It is likely that genomic variation in conserved non-genic sequences is associated with phenotypic variability and human disorders.

As an example, skeletal malformations and dysplasias, often detected through routine prenatal ultrasound examination, constitute a phenotypic finding in more than 300 syndromic and non-syndromic disorders and their genetic etiology may be due to a wide variety of genetic aberrations, ranging from copy number variations to single gene mutations.

Richard Svanbäck & Peter Eklöv — 2006 (1)([email protected]) Keywords: adaptive variation, genetic variation, perch, phenotypic plasticity, trophic polymorphism

Caitlin R. Gabor, Andrea S. Aspbury & Rafael L. Rodríguez 2013 (6)([email protected]) Keywords: environmental variation, phenotypic plasticity, reproductive isolation, sexual selection, speciation

Fixed mutations and structural genomic variations were found potentially linked to the phenotypic changes observed.

Variation in feeding morphology between pumpkinseed populations: phenotypic plasticity or evolution?

Our facility houses two third - generation Helios mass cytometers that can routinely analyze more than 40 markers per tube to provide an unprecedented «systems - level» view of phenotypic and functional variations among single cells within heterogeneous cell populations.

Susan A. Foster 2013 (6)([email protected]) Keywords: anthropogenic environmental change, behavioural phenotype, contemporary evolution, evolutionary mismatch, geographic variation, phenotypic plasticity

Genetic variation and phenotypic plasticity: causes of morphological and dietary variation in Eurasian perch.

We approach these questions by focusing on species that inhabit extreme environments and by quantifying genomic, phenotypic, and performance variation along environmental gradients.

Genetic and phenotypic intra-species variation in Candida albicans.

Genetic architecture describes the characteristics of genetic variation that are responsible for heritable phenotypic variability.

Dr. Bailey - Wilson specializes in statistical genetics and genetic epidemiology, which are disciplines of genetics that combine statistics, epidemiology, mathematics, molecular genetics and computer science to identify genetic variants responsible for increased susceptibility to disease and variation of phenotypic traits.

Structural rearrangements have long been recognized as an important source of genetic variation, with implications in phenotypic diversity and disease, yet their detailed evolutionary dynamics remain elusive.

These disciplines combine statistics, epidemiology, mathematics, molecular genetics and computer science to identify genetic variants responsible for increased susceptibility to disease and variation of phenotypic traits.

The focus of the conference was connecting how epigenetics (cellular and physiological phenotypic trait variations that are caused by external or environmental factors that switch genes on and off and affect how cells read genes instead of being caused by changes in the DNA sequence — in other words nutrition and lifestyle choices) impact whether or not an individual actually develops a specific health issue even though they have a SNP mutation.

Variation in genetic background may alter expression of the disease allele in affected animals, thus accounting for variation in phenotypic expression of theVariation in genetic background may alter expression of the disease allele in affected animals, thus accounting for variation in phenotypic expression of thevariation in phenotypic expression of the disease.

This substantial input of variation from wild ancestors has provided the raw material for phenotypic change, but unique development and genetic mechanisms may also have assisted the course of artificial selection.

The loss of genetic diversity in purebred dogs can be attributed to two major population bottleneck events: the first occurring during domestication; and the second arising from breed formation where the repeated use of popular sires, line breeding, breeding for specific phenotypic traits, and promotion of the breed barrier rule, contributed to overall loss in genetic variation [15 - 19].

We did not associate runs of homozygosity in English bulldogs with characteristic phenotypic traits but are confident based on previous studies that the greater genomic variation in English bulldogs compared to Standard Poodles reflected stronger human - directed selection in the former breed than in the latter.

Moreover, variation in breeding success between males is a main source of phenotypic selection pressures, and, hence, elephant seals are a modal species for the study of sexual selection and evolution of secondary sexual traits.

Natural spatial and temporal variability in the pH / pCO2 conditions experienced by marine populations provide the potential for different levels of adaptation (genetic) and acclimatization (phenotypic) to decreased pH and elevated pCO2, emphasizing the importance of understanding physiological variation existing along natural environmental gradients (macrophysiology) in understanding global change impacts [29].