Sentences with phrase «phenotyping data for»

These datasets include: the actual genome sequences of the 1,011 isolates; the list of 4,940 common «core» ORFs plus 2,856 ORFs that are variable within the population (together these make up the «pangenome»); copy number variation (CNV) data; phenotyping data for 36 conditions; SNPs and indels relative to the S288C genome; and much more.

We have generated rich genomic datasets for the scientific community, including an expansive atlas of genetic associations with metabolites, whole - genome sequence and phenotype data for population cohorts in the UK10K project, as well as bioinformatic resources to facilitate the retrieval of information, including a metabolite network, a database of genotype - metabolite associations with our colleagues at the HelmHoltz institute, and a genome browser of UK10K association results.

Not exact matches

Those data were then combined with information about functional changes in cell behavior to develop a nanomechanical profile, or phenotype, for specific cellular states.

Since 2007, the GWAS policy has governed biomedical researchers» submission and access to human data through the NIH database for Genotypes and Phenotypes (dbGaP).

By now, the BXD community has gathered around 300 million phenotype data points from these animals, generating by far the largest coherent «phenome» (a set of all phenotypes expressed in an organism) for any animal experimental cohort.

The data demonstrate that unique roles for IL - 15Rα and IL - 15 in vivo exist, since interruption of IL - 15 signaling by deletion of either IL - 15 or IL - 15Rα resulted in differing mouse phenotypes.

The IMI could also control and organize access to metadata (the associated host disease phenotype data, for a human gut microbiota sample, for instance) without which meaningful interpretation of the data is not possible.

This consortium developped new statistical methods for pipeline design and data analysis aimed at detecting reproducible phenotypes with high power.

Harmonising ontological descriptions of phenotype in mouse and human and improving links between mouse model data and human data, using diabetes and obesity as examples, will increase the relevance of data that is generated in mouse studies for clinical studies.

Support attendees in use of European and international resources for mouse phenogenomics (cryopreservation, distribution and phenotyping data lines already characterized and available to the scientific community).

The resulting data are being combined in a systems biology approach with high - resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models to identify disease - associated genetic variants, disease - defining molecular signatures, and potential targets for therapeutic intervention.

Data analyses of the combined genotype - phenotype data (where applicable) will be performed collaboratively and each party will be free to: (i) use these datasets for its internal research; (ii) publish results; (iii) use published results for any and all purpoData analyses of the combined genotype - phenotype data (where applicable) will be performed collaboratively and each party will be free to: (i) use these datasets for its internal research; (ii) publish results; (iii) use published results for any and all purpodata (where applicable) will be performed collaboratively and each party will be free to: (i) use these datasets for its internal research; (ii) publish results; (iii) use published results for any and all purposes.

A similar discrimination of results from SSR or SNP genotyping based on D - samples (dead) and race phenotyping from live samples is under development for stem rust data.

«We are trying to combine them all to model and analyze those data types jointly, looking at multiple phenotypes simultaneously and looking for possible environmental factors.»

For example, 2013 saw studies showing that transplanting human fecal microbiota into mice could induce obesity and its associated metabolic phenotypes, and human data from a controlled study suggesting the procedure could treat recurrent C. difficileinfection.

When coupled with phenotype data, such cohorts also provide greater power to study rare, deleterious variants in populations enriched for them.

When a cohort was provided for phenotyping, resulting phenotype data will be available to applicants within 9 months.

The study, integration and analysis of these data increasingly allows to unravel the genetic mechanisms and networks underlying complex biological phenotypes paving the way for an era of «genomic medicine,» in which new diagnostic and therapeutic approaches to common multifactorial conditions are emerging.

Other pilot projects in the ELIXIR construction phase are exploring aspects of virtual machine, continuous transfer of major archive resources, simplification of authentication of data for European Genotype Phenotype Archive (EGA) and shared responsibility for production of the EGA.

During the course of the EUMODIC project the pipeline for phenotyping, SOPs and data analyses were continuously optimized to use the fewest number of animals possible.

He is currently head of the Ensembl project and has held leadership roles in data management activities for the 1000 Genomes Project, the International Human Epigenome Consortium (IHEC) and the International Mouse Phenotyping Consortium (IMPC).

There are already well established databases within the consortium, the London Pain Database (LPD) and QUAST (DFNS, Germany): The LPD is used for datamining of functional genomics data to help identify individual genes and functional networks associated with chronic pain, QUAST on the other hand collects questionnaire data, clinical and neurophysiological findings and calculates valid clusters of phenotypes with different interaction patterns of sensory loss with and without different types of peripheral and central hyperalgesia based on QST (quantitative sensory testing) data.

For each mouse line, Lexicon provided not only the mouse strain itself, but also detailed, objective data on the impact of the specific gene deletion on the mouse's phenotype, which includes appearance, health, fitness, behavior, ability to reproduce, and radiological and microscopic data.

The database will allow users to view and download computed GTEx results and provide a controlled access system for de-identified individual - level genotype, expression, and clinical data through NCBI's database of Genotypes and Phenotypes, at http://www.ncbi.nlm.nih.gov/gap.

For each mouse line, Deltagen provided the mouse strain, but also detailed, objective data on the impact of the specific gene deletion on the mouse's phenotype, which includes appearance, health, fitness, behavior, ability to reproduce, and radiological and microscopic data.

Third, as the phenotyping phase of IKMC begins, care must be taken when comparing new behavioral data from B6N substrains with existing data from B6J, particularly for behavioral phenotypes (Kumar et.

The Mammalian Phenotype Ontology as a unifying standard for experimental and high - throughput phenotyping data

We thank the breeders and owners of Swedish vallhund dogs worldwide for their permission to collect phenotype data as well as for the generous donation of blood and tissue samples.

This greater risk of psychopathology is also likely to extend to other phenotypes associated with the opioid and serotonin systems for which there is less available data, such as antisocial behavior and substance abuse.

Furthermore, a cross-trait cross-twin association between stress reactivity and subclinical psychosis was found, indicating that emotional reactivity to stress may be an unconfounded intermediate phenotype associated with genetic risk for psychosis (T. Lataster, M. Wichers, N. Jacobs, et al, unpublished data).